Systemic lupus erythematosus causes: Difference between revisions

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{{CMG}}; {{AE}} {{MIR}} {{RT}}
{{CMG}}; {{AE}} {{MIR}} {{RT}}
==Overview==
==Overview==
There are no established causes for systemic lupus erythematosus. Common causes of systemic lupus erythematosus include [[genetic]] predisposition, [[Auto-immune disease|auto-immune diseases]], and use of drugs. Less common causes of systemic lupus erythematosus include environmental factors and exposure to [[Ultraviolet light|ultraviolet (UV) light.]]
There are no established direct causes of systemic lupus erythematosus. Common contributory factors in the development of systemic lupus erythematosus include [[genetic]] predisposition, [[Auto-immune disease|auto-immune diseases]], and use of drugs. Less common factors include environmental factors and exposure to [[Ultraviolet light|ultraviolet (UV) light.]]


==Causes==
==Causes==
* [[Genetic]] predisposition:<ref name="pmid8749564">{{cite journal |vauthors=Schur PH |title=Genetics of systemic lupus erythematosus |journal=Lupus |volume=4 |issue=6 |pages=425–37 |year=1995 |pmid=8749564 |doi=10.1177/096120339500400603 |url=}}</ref>
* [[Genetic]] predisposition:<ref name="pmid8749564">{{cite journal |vauthors=Schur PH |title=Genetics of systemic lupus erythematosus |journal=Lupus |volume=4 |issue=6 |pages=425–37 |year=1995 |pmid=8749564 |doi=10.1177/096120339500400603 |url=}}</ref>
** [[HLA]] class [[polymorphism]]
**[[HLA]] class [[polymorphism]]
** [[Complement]] genes
** [[Complement]] genes
** Female sexual gene due to high levels of [[estrogen]] and [[prolactin]]
** Female sexual gene due to high levels of [[estrogen]] and [[prolactin]]
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** Can exacerbate or induce systemic manifestations of SLE 
** Can exacerbate or induce systemic manifestations of SLE 
* Drug-induced lupus
* Drug-induced lupus
{{Columns-list|3|
** [[Acebutolol]]
** [[Adalimumab]]
** [[Anastrozole]]
** [[Bupropion]]
** [[Captopril]]
** [[Cilazapril]]
** [[Cinnarizine]]/[[thiethylperazine]]
** [[Diltiazem]]
** [[Docetaxel]]
** [[Doxorubicin]]
** [[Penicillamine|D-penicillamine]]
** [[Etanercept]]
** [[Gemcitabine]]
** [[Glyburide]]
** [[Golimumab]]
** [[Griseofulvin]]
** [[Hydrochlorothiazide]]
** [[Infliximab]]
** [[Interferon-alpha]]
** [[Interferon-beta]]
** [[Oxprenolol]]
** [[Phenytoin]]
** [[Lamotrigine]]
** [[Lansoprazole]]
** [[Leflunomide]]
** [[Leuprorelin]]
** [[Naproxen]]
** [[Nifedipine]]
** [[Nitrendipine]]
** [[Omeprazole]]
** [[Paclitaxel]]
** [[Pantoprazole]]
** [[Piroxicam]]
** [[Pravastatin]]
** [[Ranitidine]]
** [[Simvastatin]]
** [[Spironolactone]]
** [[Tamoxifen]]
** [[Terbinafine]]
** [[Ticlopidine]]
** [[Verapamil]]
** [[Sulfonamide]]s
}}


==References==
==References==

Latest revision as of 12:58, 17 October 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mahshid Mir, M.D. [2] Raviteja Guddeti, M.B.B.S. [3]

Overview

There are no established direct causes of systemic lupus erythematosus. Common contributory factors in the development of systemic lupus erythematosus include genetic predisposition, auto-immune diseases, and use of drugs. Less common factors include environmental factors and exposure to ultraviolet (UV) light.

Causes

  • Exposure to ultraviolet (UV) light[3]
    • Can exacerbate or induce systemic manifestations of SLE 
  • Drug-induced lupus

References

  1. Schur PH (1995). "Genetics of systemic lupus erythematosus". Lupus. 4 (6): 425–37. doi:10.1177/096120339500400603. PMID 8749564.
  2. Cutolo M, Sulli A, Seriolo B, Accardo S, Masi AT (1995). "Estrogens, the immune response and autoimmunity". Clin. Exp. Rheumatol. 13 (2): 217–26. PMID 7656468.
  3. Cooper GS, Dooley MA, Treadwell EL, St Clair EW, Gilkeson GS (2002). "Risk factors for development of systemic lupus erythematosus: allergies, infections, and family history". J Clin Epidemiol. 55 (10): 982–9. PMID 12464374.

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