Systemic lupus erythematosus causes: Difference between revisions

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{{Systemic lupus erythematosus}}
{{Systemic lupus erythematosus}}


{{CMG}}; {{AE}} {{RT}}
{{CMG}}; {{AE}} {{MIR}} {{RT}}
==Overview==
There are no established direct causes of systemic lupus erythematosus. Common contributory factors in the development of systemic lupus erythematosus include [[genetic]] predisposition, [[Auto-immune disease|auto-immune diseases]], and use of drugs. Less common factors include environmental factors and exposure to [[Ultraviolet light|ultraviolet (UV) light.]]


==Causes==
* [[Genetic]] predisposition:<ref name="pmid8749564">{{cite journal |vauthors=Schur PH |title=Genetics of systemic lupus erythematosus |journal=Lupus |volume=4 |issue=6 |pages=425–37 |year=1995 |pmid=8749564 |doi=10.1177/096120339500400603 |url=}}</ref>
**[[HLA]] class [[polymorphism]]
** [[Complement]] genes
** Female sexual gene due to high levels of [[estrogen]] and [[prolactin]]
* [[Auto-immune]] disease<ref name="pmid7656468">{{cite journal |vauthors=Cutolo M, Sulli A, Seriolo B, Accardo S, Masi AT |title=Estrogens, the immune response and autoimmunity |journal=Clin. Exp. Rheumatol. |volume=13 |issue=2 |pages=217–26 |year=1995 |pmid=7656468 |doi= |url=}}</ref>


==Overview==
* Infections
==Causes==
** [[Parvovirus B19]]
Despite the dramatic rise in '''lupus''' research in recent years, the exact cause of the disease remains unknown.  Indeed, consensus is still lacking on whether lupus is a single condition or a group of related diseases. [[SLE]] is a chronic [[inflammation|inflammatory]] disease believed to be a [[Hypersensitivity#Type III - immune complex|type III hypersensitivity]] response with potential [[Hypersensitivity#Type 2 - antibody-dependent|type II]] involvement,<ref>[http://pathmicro.med.sc.edu/ghaffar/hyper00.htm University of South Carolina lecture on immunology]</ref> characterized by the body's production of antibodies against the nuclear components of its own cells. There are three mechanisms by which lupus is thought to develop:
** [[Epstein-Barr virus|Epstein-Barr virus (EBV)]]
* Genetic predisposition
** [[Trypanosomiasis]]
* Environmental triggers
** [[Mycobacterial infection|Mycobacterial infections]] 
* Drug reaction ([[drug-induced lupus]]) - There are about 400 medications currently in use that can cause this condition, though the most common drugs are
 
** [[Ethosuximide]]
* Exposure to [[ultraviolet]] (UV) light<ref name="pmid12464374">{{cite journal |vauthors=Cooper GS, Dooley MA, Treadwell EL, St Clair EW, Gilkeson GS |title=Risk factors for development of systemic lupus erythematosus: allergies, infections, and family history |journal=J Clin Epidemiol |volume=55 |issue=10 |pages=982–9 |year=2002 |pmid=12464374 |doi= |url=}}</ref>
** [[Ethotoin]]
** Can exacerbate or induce systemic manifestations of SLE 
** [[Procainamide]]
* Drug-induced lupus
** [[Hydralazine]]
** [[Quinidine]]
** [[Losartan potassium and Hydrochlorothiazide]]
** [[Oxcarbazepine]]
** [[Oxytetracycline]]
** [[Pegylated interferon alfa-2b]]
**[[Dapsone]]
** [[Trimethadione]]
**[[Trientine]]
*Drugs excerbating SLE:
** [[Doxycycline]]


==References==
==References==

Latest revision as of 12:58, 17 October 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mahshid Mir, M.D. [2] Raviteja Guddeti, M.B.B.S. [3]

Overview

There are no established direct causes of systemic lupus erythematosus. Common contributory factors in the development of systemic lupus erythematosus include genetic predisposition, auto-immune diseases, and use of drugs. Less common factors include environmental factors and exposure to ultraviolet (UV) light.

Causes

  • Exposure to ultraviolet (UV) light[3]
    • Can exacerbate or induce systemic manifestations of SLE 
  • Drug-induced lupus

References

  1. Schur PH (1995). "Genetics of systemic lupus erythematosus". Lupus. 4 (6): 425–37. doi:10.1177/096120339500400603. PMID 8749564.
  2. Cutolo M, Sulli A, Seriolo B, Accardo S, Masi AT (1995). "Estrogens, the immune response and autoimmunity". Clin. Exp. Rheumatol. 13 (2): 217–26. PMID 7656468.
  3. Cooper GS, Dooley MA, Treadwell EL, St Clair EW, Gilkeson GS (2002). "Risk factors for development of systemic lupus erythematosus: allergies, infections, and family history". J Clin Epidemiol. 55 (10): 982–9. PMID 12464374.

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