Glioblastoma multiforme MRI: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Glioblastoma multiforme}} | {{Glioblastoma multiforme}} | ||
{{CMG}} | {{CMG}}{{AE}}{{SR}} | ||
==Overview== | ==Overview== | ||
Brain MRI is helpful in the diagnosis of glioblastoma multiforme. On brain MRI, glioblastoma multiforme is characterized by a butterfly shaped mass, which is hypointense on T1-weighted [[MRI]] and hyperintense on T2-weighted MRI. | |||
==MRI== | ==MRI== | ||
Brain MRI is helpful in the diagnosis of glioblastoma. On brain MRI, glioblastoma is characterized by: | Brain MRI is helpful in the diagnosis of glioblastoma multiforme. On brain [[MRI]], glioblastoma multiforme is characterized by: | ||
{| style="border: 0px; font-size: 90%; margin: 3px; width: 600px" align=center | [[File:Glioblastoma-GIF1.gif|thumb|200px|sagital section of brain showing Glioblastoma multiforme [https://upload.wikimedia.org/wikipedia/commons/b/b2/Animazione_RMN_saggittale_dopo_rimozione_glioblastoma.gif Source:Wikimedia Commons] ]] | ||
|valign=top| | |||
[[File:GlioblastomaGIF2.gif|thumb|200px|Transverse section of brain showing Glioblastoma multiforme [https://upload.wikimedia.org/wikipedia/commons/c/ce/Animazione_RMN_trasversale_dopo_rimozione_glioblastoma.gif Source:Wikimedia Commons] ]] | |||
[[File:Glioblastoma multiforme - MRi.jpg|thumb|200px|Transverse section of brain showing Glioblastoma multiforme [https://upload.wikimedia.org/wikipedia/commons/0/0f/Glioblastoma_multiforme_-_MRT_T2_ax.jpg Source:Wikimedia Commons] ]] | |||
{| style="border: 0px; font-size: 90%; margin: 3px; width: 600px" align="center" | |||
| valign="top" | | |||
|+ | |+ | ||
! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|MRI component}} | ! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|MRI component}} | ||
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:T1 | :T1 | ||
| style="padding: 5px 5px; background: #F5F5F5;" | | | style="padding: 5px 5px; background: #F5F5F5;" | | ||
*Butterfly shaped mass | |||
*Hypo to isointense mass within [[white matter]] | *Hypo to isointense mass within [[white matter]] | ||
*Central heterogenous signal ([[necrosis]], intratumoral [[hemorrhage]]) | *Central heterogenous signal ([[necrosis]], intratumoral [[hemorrhage]]) | ||
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| style="padding: 5px 5px; background: #F5F5F5;" | | | style="padding: 5px 5px; background: #F5F5F5;" | | ||
*Enhancement is variable | *Enhancement is variable | ||
*Typically peripheral and irregular with nodular components | *Typically peripheral and irregular with [[nodular]] components | ||
*Usually completely surrounds [[necrosis]] | *Usually completely surrounds [[necrosis]] | ||
|- | |- | ||
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:GE/SWI | :GE/SWI | ||
| style="padding: 5px 5px; background: #F5F5F5;" | | | style="padding: 5px 5px; background: #F5F5F5;" | | ||
*Susceptibility artifact on T2 from blood products (or occasionally calcification) | *Susceptibility artifact on T2 from blood products (or occasionally [[calcification]]) | ||
*Low intensity rim from blood product | *Low intensity rim from blood product | ||
*Located inside the peripheral enhancing component | *Located inside the peripheral enhancing component | ||
*Absent dual rim sign | *Absent dual rim sign | ||
|- | |- | ||
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" | | | rowspan="3" style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |DWI/ADC | ||
| style="padding: 5px 5px; background: #F5F5F5;" | | | style="padding: 5px 5px; background: #F5F5F5;" | | ||
*Solid component | *Solid component | ||
:* Elevated signal on DWI is common in solid / enhancing component | |||
:* Diffusion restriction is typically intermediate similar to normal [[white matter]], but significantly elevated compared to surrounding vasogenic [[edema]] (which has facilitated diffusion) | |||
*ADC values correlate with grade: | |- | ||
| style="padding: 5px 5px; background: #F5F5F5;" | | |||
* ADC values correlate with grade: | |||
:* WHO IV (GBM) = 745 ± 135 x 10-6 mm2/s | |||
:* WHO III (anaplastic) = 1067 ± 276 x 10-6 mm2/s | |||
*Non-enhancing necrotic / cystic component | :* WHO II (low grade) = 1273 ± 293 x 10-6 mm2/s | ||
:* ADC threshold value of 1185 x 10-6 mm2/s sensitivity (97.6%) and specificity (53.1%) in the discrimination of high-grade (WHO grade III & IV) and low-grade (WHO grade II) gliomas | |||
|- | |||
| style="padding: 5px 5px; background: #F5F5F5;" | | |||
* Non-enhancing necrotic / cystic component | |||
:* Majority (>90%) have facilitated diffusion (ADC values > 1000 x 10-6 mm2/s) | |||
|- | |- | ||
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" | | | style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" | | ||
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:MR spectroscopy | :MR spectroscopy | ||
| style="padding: 5px 5px; background: #F5F5F5;" | | | style="padding: 5px 5px; background: #F5F5F5;" | | ||
*Choline: increased | *[[Choline]]: increased | ||
*Lactate: increased | *[[Lactate]]: increased | ||
*Lipids: increased | *[[Lipids]]: increased | ||
*NAA: decreased | *[[N-Acetylaspartate|NAA]]: decreased | ||
*Myo-inositol: decreased | *[[Myo-inositol]]: decreased | ||
|- | |- | ||
|} | |} | ||
<div align="left"> | <div align="left"></div> | ||
</div | |||
==References== | ==References== | ||
[[Category:Neurosurgery]] | [[Category:Neurosurgery]] | ||
[[Category:Neurology]] | [[Category:Neurology]] | ||
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{{WikiDoc Help Menu}} | {{WikiDoc Help Menu}} | ||
{{WikiDoc Sources}} | {{WikiDoc Sources}} | ||
<references /> |
Latest revision as of 23:33, 15 April 2019
Glioblastoma multiforme Microchapters |
Diagnosis |
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Treatment |
Case Studies |
Glioblastoma multiforme MRI On the Web |
American Roentgen Ray Society Images of Glioblastoma multiforme MRI |
Risk calculators and risk factors for Glioblastoma multiforme MRI |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Brain MRI is helpful in the diagnosis of glioblastoma multiforme. On brain MRI, glioblastoma multiforme is characterized by a butterfly shaped mass, which is hypointense on T1-weighted MRI and hyperintense on T2-weighted MRI.
MRI
Brain MRI is helpful in the diagnosis of glioblastoma multiforme. On brain MRI, glioblastoma multiforme is characterized by:
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