TREX2: Difference between revisions

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{{Underlinked|date=March 2014}}
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{{Infobox_gene}}
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'''Three prime repair exonuclease 2''' is an [[enzyme]] that in humans is encoded by the ''TREX2'' [[gene]].<ref name="pmid10391904">{{cite journal | vauthors = Mazur DJ, Perrino FW | title = Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'-->5' exonucleases | journal = J Biol Chem | volume = 274 | issue = 28 | pages = 19655–60 |date=Aug 1999 | pmid = 10391904 | pmc =  | doi =10.1074/jbc.274.28.19655 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TREX2 three prime repair exonuclease 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11219| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_TREX2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1y97.
| PDB = {{PDB2|1y97}}
| Name = Three prime repair exonuclease 2
| HGNCid = 12270
| Symbol = TREX2
| AltSymbols =;
| OMIM = 300370
| ECnumber = 
| Homologene = 8046
| MGIid = 1346343
| Function = {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004527 |text = exonuclease activity}} {{GNF_GO|id=GO:0008296 |text = 3'-5'-exodeoxyribonuclease activity}} {{GNF_GO|id=GO:0008853 |text = exodeoxyribonuclease III activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} {{GNF_GO|id=GO:0016810 |text = hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds}} {{GNF_GO|id=GO:0031996 |text = thioesterase binding}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
  | Process = {{GNF_GO|id=GO:0006281 |text = DNA repair}} {{GNF_GO|id=GO:0006807 |text = nitrogen compound metabolic process}} {{GNF_GO|id=GO:0042177 |text = negative regulation of protein catabolic process}} {{GNF_GO|id=GO:0043161 |text = proteasomal ubiquitin-dependent protein catabolic process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 11219
    | Hs_Ensembl =   
    | Hs_RefseqProtein = NP_542432
    | Hs_RefseqmRNA = NM_080701
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 24102
    | Mm_Ensembl = ENSMUSG00000031372
    | Mm_RefseqmRNA = NM_011907
    | Mm_RefseqProtein = NP_036037
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = X
    | Mm_GenLoc_start = 69686425
    | Mm_GenLoc_end = 69688050
    | Mm_Uniprot = Q3SXB3
  }}
}}
'''Three prime repair exonuclease 2''', also known as '''TREX2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TREX2 three prime repair exonuclease 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11219| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a protein with 3' exonuclease activity. Enzymes with this activity are involved in DNA replication, repair, and recombination. Similarity to an E. coli protein suggests that this enzyme may be a subunit of DNA polymerase III, which does not have intrinsic exonuclease activity.<ref name="entrez">{{cite web | title = Entrez Gene: TREX2 three prime repair exonuclease 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11219| accessdate = }}</ref>
| summary_text = This gene encodes a protein with 3' exonuclease activity. Enzymes with this activity are involved in DNA replication, repair, and recombination. Similarity to an E. coli protein suggests that this enzyme may be a subunit of DNA polymerase III, which does not have intrinsic exonuclease activity.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Shevelev IV, Hübscher U |title=The 3' 5' exonucleases. |journal=Nat. Rev. Mol. Cell Biol. |volume=3 |issue= 5 |pages= 364-76 |year= 2002 |pmid= 11988770 |doi= 10.1038/nrm804 }}
*{{cite journal  | vauthors=Shevelev IV, Hübscher U |title=The 3' 5' exonucleases |journal=Nat. Rev. Mol. Cell Biol. |volume=3 |issue= 5 |pages= 364–76 |year= 2002 |pmid= 11988770 |doi= 10.1038/nrm804 }}
*{{cite journal | author=Esposito T, Ciccodicola A, Flagiello L, ''et al.'' |title=Expressed STSs and transcription of human Xq28. |journal=Gene |volume=187 |issue= 2 |pages= 185-91 |year= 1997 |pmid= 9099879 |doi= }}
*{{cite journal   |vauthors=Esposito T, Ciccodicola A, Flagiello L, etal |title=Expressed STSs and transcription of human Xq28 |journal=Gene |volume=187 |issue= 2 |pages= 185–91 |year= 1997 |pmid= 9099879 |doi=10.1016/S0378-1119(96)00772-X }}
*{{cite journal  | author=Mazur DJ, Perrino FW |title=Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'-->5' exonucleases. |journal=J. Biol. Chem. |volume=274 |issue= 28 |pages= 19655-60 |year= 1999 |pmid= 10391904 |doi= }}
*{{cite journal  | vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000  | pmc=310948 }}
*{{cite journal  | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi=  }}
*{{cite journal   |vauthors=Li T, Duan W, Yang H, etal |title=Identification of two proteins, S14 and UIP1, that interact with UCH37 |journal=FEBS Lett. |volume=488 |issue= 3 |pages= 201–5 |year= 2001 |pmid= 11163772 |doi=10.1016/S0014-5793(00)02436-4 }}
*{{cite journal | author=Li T, Duan W, Yang H, ''et al.'' |title=Identification of two proteins, S14 and UIP1, that interact with UCH37. |journal=FEBS Lett. |volume=488 |issue= 3 |pages= 201-5 |year= 2001 |pmid= 11163772 |doi=  }}
*{{cite journal   |vauthors=Simpson JC, Wellenreuther R, Poustka A, etal |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 | pmc=1083732 }}
*{{cite journal | author=Simpson JC, Wellenreuther R, Poustka A, ''et al.'' |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287-92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 }}
*{{cite journal  | vauthors=Mazur DJ, Perrino FW |title=Structure and expression of the TREX1 and TREX2 3' --> 5' exonuclease genes |journal=J. Biol. Chem. |volume=276 |issue= 18 |pages= 14718–27 |year= 2001 |pmid= 11278605 |doi= 10.1074/jbc.M010051200 }}
*{{cite journal  | author=Mazur DJ, Perrino FW |title=Structure and expression of the TREX1 and TREX2 3' --> 5' exonuclease genes. |journal=J. Biol. Chem. |volume=276 |issue= 18 |pages= 14718-27 |year= 2001 |pmid= 11278605 |doi= 10.1074/jbc.M010051200 }}
*{{cite journal  | vauthors=Mazur DJ, Perrino FW |title=Excision of 3' termini by the Trex1 and TREX2 3'-->5' exonucleases. Characterization of the recombinant proteins |journal=J. Biol. Chem. |volume=276 |issue= 20 |pages= 17022–9 |year= 2001 |pmid= 11279105 |doi= 10.1074/jbc.M100623200 }}
*{{cite journal  | author=Mazur DJ, Perrino FW |title=Excision of 3' termini by the Trex1 and TREX2 3'-->5' exonucleases. Characterization of the recombinant proteins. |journal=J. Biol. Chem. |volume=276 |issue= 20 |pages= 17022-9 |year= 2001 |pmid= 11279105 |doi= 10.1074/jbc.M100623200 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Shevelev IV, Beliakova NV, Kravetskaia TP, Krutiakov VM |title=[The correcting role of autonomous 3'-->5' exonucleases in mammalian multienzyme DNA polymerase complexes] |journal=Mol. Biol. (Mosk.) |volume=36 |issue= 6 |pages= 1055–61 |year= 2003 |pmid= 12500544 |doi=  }}
*{{cite journal  | author=Shevelev IV, Beliakova NV, Kravetskaia TP, Krutiakov VM |title=[The correcting role of autonomous 3'-->5' exonucleases in mammalian multienzyme DNA polymerase complexes] |journal=Mol. Biol. (Mosk.) |volume=36 |issue= 6 |pages= 1055-61 |year= 2003 |pmid= 12500544 |doi=  }}
*{{cite journal  | vauthors=Shevelev IV, Ramadan K, Hübscher U |title=The TREX2 3'-->5' exonuclease physically interacts with DNA polymerase delta and increases its accuracy |journal=ScientificWorldJournal |volume=2 |issue=  |pages= 275–81 |year= 2004 |pmid= 12806015 |pmc=6009725 |doi= 10.1100/tsw.2002.99 }}
*{{cite journal  | author=Shevelev IV, Ramadan K, Hübscher U |title=The TREX2 3'-->5' exonuclease physically interacts with DNA polymerase delta and increases its accuracy. |journal=ScientificWorldJournal |volume=2 |issue=  |pages= 275-81 |year= 2004 |pmid= 12806015 |doi= 10.1100/tsw.2002.99 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Wiemann S, Arlt D, Huber W, etal |title=From ORFeome to biology: a functional genomics pipeline |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 | pmc=528930 }}
*{{cite journal | author=Wiemann S, Arlt D, Huber W, ''et al.'' |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136-44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 }}
*{{cite journal   |vauthors=Perrino FW, Krol A, Harvey S, etal |title=Sequence variants in the 3'-->5' deoxyribonuclease TREX2: identification in a genetic screen and effects on catalysis by the recombinant proteins |journal=Adv. Enzyme Regul. |volume=44 |issue=  |pages= 37–49 |year= 2005 |pmid= 15581481 |doi= 10.1016/j.advenzreg.2003.11.010 }}
*{{cite journal | author=Perrino FW, Krol A, Harvey S, ''et al.'' |title=Sequence variants in the 3'-->5' deoxyribonuclease TREX2: identification in a genetic screen and effects on catalysis by the recombinant proteins. |journal=Adv. Enzyme Regul. |volume=44 |issue=  |pages= 37-49 |year= 2005 |pmid= 15581481 |doi= 10.1016/j.advenzreg.2003.11.010 }}
*{{cite journal  | vauthors=Perrino FW, Harvey S, McMillin S, Hollis T |title=The human TREX2 3' -> 5'-exonuclease structure suggests a mechanism for efficient nonprocessive DNA catalysis |journal=J. Biol. Chem. |volume=280 |issue= 15 |pages= 15212–8 |year= 2005 |pmid= 15661738 |doi= 10.1074/jbc.M500108200 }}
*{{cite journal  | author=Perrino FW, Harvey S, McMillin S, Hollis T |title=The human TREX2 3' -> 5'-exonuclease structure suggests a mechanism for efficient nonprocessive DNA catalysis. |journal=J. Biol. Chem. |volume=280 |issue= 15 |pages= 15212-8 |year= 2005 |pmid= 15661738 |doi= 10.1074/jbc.M500108200 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal   |vauthors=Mehrle A, Rosenfelder H, Schupp I, etal |title=The LIFEdb database in 2006 |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 | pmc=1347501 }}
*{{cite journal | author=Mehrle A, Rosenfelder H, Schupp I, ''et al.'' |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415-8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 }}
*{{cite journal  | vauthors=Hahn Y, Lee B |title=Human-specific nonsense mutations identified by genome sequence comparisons |journal=Hum. Genet. |volume=119 |issue= 1–2 |pages= 169–78 |year= 2007 |pmid= 16395595 |doi= 10.1007/s00439-005-0125-6 |url=https://zenodo.org/record/1232721 |format=Submitted manuscript }}
*{{cite journal  | author=Hahn Y, Lee B |title=Human-specific nonsense mutations identified by genome sequence comparisons. |journal=Hum. Genet. |volume=119 |issue= 1-2 |pages= 169-78 |year= 2007 |pmid= 16395595 |doi= 10.1007/s00439-005-0125-6 }}
*{{cite journal  | vauthors=Chen MJ, Ma SM, Dumitrache LC, Hasty P |title=Biochemical and cellular characteristics of the 3' -> 5' exonuclease TREX2 |journal=Nucleic Acids Res. |volume=35 |issue= 8 |pages= 2682–94 |year= 2007 |pmid= 17426129 |doi= 10.1093/nar/gkm151 | pmc=1885668 }}
*{{cite journal  | author=Chen MJ, Ma SM, Dumitrache LC, Hasty P |title=Biochemical and cellular characteristics of the 3' -> 5' exonuclease TREX2. |journal=Nucleic Acids Res. |volume=35 |issue= 8 |pages= 2682-94 |year= 2007 |pmid= 17426129 |doi= 10.1093/nar/gkm151 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=11219}}
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Latest revision as of 22:33, 5 September 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Three prime repair exonuclease 2 is an enzyme that in humans is encoded by the TREX2 gene.[1][2]

This gene encodes a protein with 3' exonuclease activity. Enzymes with this activity are involved in DNA replication, repair, and recombination. Similarity to an E. coli protein suggests that this enzyme may be a subunit of DNA polymerase III, which does not have intrinsic exonuclease activity.[2]

References

  1. ↑ Mazur DJ, Perrino FW (Aug 1999). "Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'-->5' exonucleases". J Biol Chem. 274 (28): 19655–60. doi:10.1074/jbc.274.28.19655. PMID 10391904.
  2. ↑ 2.0 2.1 "Entrez Gene: TREX2 three prime repair exonuclease 2".

Further reading



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