Rhabdomyoma causes: Difference between revisions

Jump to navigation Jump to search
No edit summary
 
(One intermediate revision by the same user not shown)
Line 1: Line 1:
__NOTOC__
__NOTOC__
{{Rhabdomyoma}}
{{Rhabdomyoma}}
{{CMG}}{{AE}}{{Simrat}}
{{CMG}}{{AE}}{{Nnasiri}}


==Overview==
==Overview==
Line 7: Line 7:


==Causes==
==Causes==
*[[Adult]] rhabdomyomas are matured [[neoplasm]]<nowiki/>s of clonal origin.
*[[Cardiac]] rhabdomyoma may be caused by either sporadic [[mutation]] or in the setting of certain genetic disorders.<ref name="pmid18402818">{{cite journal| author=Burke A, Virmani R| title=Pediatric heart tumors. | journal=Cardiovasc Pathol | year= 2008 | volume= 17 | issue= 4 | pages= 193-8 | pmid=18402818 | doi=10.1016/j.carpath.2007.08.008 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18402818  }} </ref>
*The [[genetic]] disorder commonly associated with [[cardiac]] rhabdomyoma is [[tuberous sclerosis]].<ref name="pmid11357016">{{cite journal| author=Vaughan CJ, Veugelers M, Basson CT| title=Tumors and the heart: molecular genetic advances. | journal=Curr Opin Cardiol | year= 2001 | volume= 16 | issue= 3 | pages= 195-200 | pmid=11357016 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11357016  }} </ref> Other genetic disorders associated with cardiac rhabdomyomas include [[basal cell nevus syndrome]] and [[Down syndrome]] in the setting of [[tuberous sclerosis]].<ref name="pmid15360117">{{cite journal| author=Isaacs H| title=Fetal and neonatal cardiac tumors. | journal=Pediatr Cardiol | year= 2004 | volume= 25 | issue= 3 | pages= 252-73 | pmid=15360117 | doi=10.1007/s00246-003-0590-4 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15360117  }} </ref><ref name="pmid10419607">{{cite journal| author=Krapp M, Baschat AA, Gembruch U, Gloeckner K, Schwinger E, Reusche E| title=Tuberous sclerosis with intracardiac rhabdomyoma in a fetus with trisomy 21: case report and review of literature. | journal=Prenat Diagn | year= 1999 | volume= 19 | issue= 7 | pages= 610-3 | pmid=10419607 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10419607  }} </ref>
*The familial form of [[tuberous sclerosis]] are [[hamartomas]] that can involve the [[kidneys]], [[heart]], [[skin]], [[brain]], and other organs.
*[[Cardiac]] rhabdomyoma can be the only presenting sign of [[tuberous sclerosis]] and there are strongly related, in fact, [[tuberous sclerosis]] in a fetus can be detected as cardiac rhabdomyoma on [[ultrasound]].<ref name="pmid28868251">{{cite journal |vauthors=Sharma N, Sharma S, Thiek JL, Ahanthem SS, Kalita A, Lynser D |title=Maternal and Fetal Tuberous Sclerosis: Do We Know Enough as an Obstetrician? |journal=J Reprod Infertil |volume=18 |issue=2 |pages=257–260 |date=2017 |pmid=28868251 |pmc=5565905 |doi= |url=}}</ref>
*[[Molecular]] evidence of this association has been identified as the ''[[TSC2]]'' [[gene]] [[missense mutation]].
*[[Cardiac]] rhabdomyoma is caused by a [[mutation]] in the ''[[TSC1 (gene)|TSC1]]'' on [[chromosome]] 9q34 that encodes for protein [[hamartin]], and ''[[TSC2]]'' on 16p13 that encodes for [[tuberin]]. These [[Gene|genes]] are both [[tumor suppressor genes]] that assist in the regulation of [[growth]] and differentiation of developing [[cardiomyocyte]]<nowiki/>s<ref name="pmid2691673">{{cite journal |vauthors=Goldenberg DL |title=A review of the role of tricyclic medications in the treatment of fibromyalgia syndrome |journal=J Rheumatol Suppl |volume=19 |issue= |pages=137–9 |date=November 1989 |pmid=2691673 |doi= |url=}}</ref>


==References==
==References==

Latest revision as of 21:25, 10 January 2019

Rhabdomyoma Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Rhabdomyoma from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Staging

History and Symptoms

Physical Examination

Laboratory Findings

Biopsy

Chest X Ray

CT

MRI

Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Rhabdomyoma causes On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Rhabdomyoma causes

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Rhabdomyoma causes

CDC on Rhabdomyoma causes

Rhabdomyoma causes in the news

Blogs on Rhabdomyoma causes

Directions to Hospitals Treating Rhabdomyoma

Risk calculators and risk factors for Rhabdomyoma causes

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Nima Nasiri, M.D.[2]

Overview

Rhabdomyoma is a benign tumor of striated muscle. Rhabdomyomas are rare and can be classified into cardiac type and extracardiac type. The most common primary benign pediatric tumor of the heart is cardiac rhabdomyoma which can be seen mainly in fetal life and children, the second most common primary benign cardiac tumor in children is fibroma. Most tumors regress spontaneously, prognosis depends on the location of tumor and size. Cardiac rhabdomyoma is strongly associated with tuberous sclerosis.

Causes

References

  1. Burke A, Virmani R (2008). "Pediatric heart tumors". Cardiovasc Pathol. 17 (4): 193–8. doi:10.1016/j.carpath.2007.08.008. PMID 18402818.
  2. Vaughan CJ, Veugelers M, Basson CT (2001). "Tumors and the heart: molecular genetic advances". Curr Opin Cardiol. 16 (3): 195–200. PMID 11357016.
  3. Isaacs H (2004). "Fetal and neonatal cardiac tumors". Pediatr Cardiol. 25 (3): 252–73. doi:10.1007/s00246-003-0590-4. PMID 15360117.
  4. Krapp M, Baschat AA, Gembruch U, Gloeckner K, Schwinger E, Reusche E (1999). "Tuberous sclerosis with intracardiac rhabdomyoma in a fetus with trisomy 21: case report and review of literature". Prenat Diagn. 19 (7): 610–3. PMID 10419607.
  5. Sharma N, Sharma S, Thiek JL, Ahanthem SS, Kalita A, Lynser D (2017). "Maternal and Fetal Tuberous Sclerosis: Do We Know Enough as an Obstetrician?". J Reprod Infertil. 18 (2): 257–260. PMC 5565905. PMID 28868251.
  6. Goldenberg DL (November 1989). "A review of the role of tricyclic medications in the treatment of fibromyalgia syndrome". J Rheumatol Suppl. 19: 137–9. PMID 2691673.

Template:WH Template:WS