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{{Infobox_gene}}
{{PBB_Controls
'''Transcription factor jun-B''' is a [[protein]] that in humans is encoded by the ''JUNB'' [[gene]].<ref name="pmid2513129">{{cite journal |vauthors=Schütte J, Viallet J, Nau M, Segal S, Fedorko J, Minna J | title = jun-B inhibits and c-fos stimulates the transforming and trans-activating activities of c-jun | journal = Cell | volume = 59 | issue = 6 | pages = 987–997 | date = Feb 1990 | pmid = 2513129 | pmc =  | doi = 10.1016/0092-8674(89)90755-1 }}</ref><ref>{{cite web | title = Entrez Gene: JUNB jun B proto-oncogene | url = https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=retrieve&dopt=default&list_uids=3726&rn=1| accessdate = }}</ref> Transcription factor jun-B is a [[transcription factor]] involved in regulating gene activity following the primary growth factor response. It binds to the DNA sequence 5'-TGA[CG]TCA-3'.
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
==Interactions==
{{GNF_Protein_box
JUNB has been shown to [[Protein-protein interaction|interact]] with
| image =
* [[BRCA1]],<ref name = pmid12080089>{{cite journal |vauthors=Hu YF, Li R | title = JunB potentiates function of BRCA1 activation domain 1 (AD1) through a coiled-coil-mediated interaction | journal = Genes Dev. | volume = 16 | issue = 12 | pages = 1509–17 | date = Jun 2002 | pmid = 12080089 | pmc = 186344 | doi = 10.1101/gad.995502 }}</ref> and
| image_source =
* [[Mothers against decapentaplegic homolog 3|SMAD3]].<ref name = pmid10220381>{{cite journal |vauthors=Liberati NT, Datto MB, Frederick JP, Shen X, Wong C, Rougier-Chapman EM, Wang XF | title = Smads bind directly to the Jun family of AP-1 transcription factors | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 96 | issue = 9 | pages = 4844–9 | date = Apr 1999 | pmid = 10220381 | pmc = 21779 | doi =  10.1073/pnas.96.9.4844}}</ref>
| PDB =  
| Name = Jun B proto-oncogene
| HGNCid = 6205
| Symbol = JUNB
| AltSymbols =;
| OMIM = 165161
| ECnumber = 
| Homologene = 7390
| MGIid = 96647
| GeneAtlas_image1 = PBB_GE_JUNB_201473_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003702 |text = RNA polymerase II transcription factor activity}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0003714 |text = transcription corepressor activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046983 |text = protein dimerization activity}}  
| Component = {{GNF_GO|id=GO:0000785 |text = chromatin}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006357 |text = regulation of transcription from RNA polymerase II promoter}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3726
    | Hs_Ensembl = ENSG00000171223
    | Hs_RefseqProtein = NP_002220
    | Hs_RefseqmRNA = NM_002229
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 12763286
    | Hs_GenLoc_end = 12765129
    | Hs_Uniprot = P17275
    | Mm_EntrezGene = 16477
    | Mm_Ensembl = ENSMUSG00000052837
    | Mm_RefseqmRNA = NM_008416
    | Mm_RefseqProtein = NP_032442
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 8
    | Mm_GenLoc_start = 87867500
    | Mm_GenLoc_end = 87868534
    | Mm_Uniprot = Q3TXR4
  }}
}}
'''Jun B proto-oncogene''', also known as '''JUNB''', is a human [[gene]].<ref>{{cite web | title = Entrez Gene: JUNB jun B proto-oncogene | url = http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=retrieve&dopt=default&list_uids=3726&rn=1| accessdate = }}</ref>
 
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{{PBB_Summary
| section_title =
| summary_text =
}}


==See also==
==See also==
Line 58: Line 11:


==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal |vauthors=Hsu JC, Bravo R, Taub R | title = Interactions among LRF-1, JunB, c-Jun, and c-Fos define a regulatory program in the G1 phase of liver regeneration | journal = Mol. Cell. Biol. | volume = 12 | issue = 10 | pages = 4654–65 | year = 1992 | pmid = 1406655 | pmc = 360392 | doi =  }}
| citations =
*{{cite journal |vauthors=Zafarullah M, Martel-Pelletier J, Cloutier JM, Gedamu L, Pelletier JP | title = Expression of c-fos, c-jun, jun-B, metallothionein and metalloproteinase genes in human chondrocyte | journal = FEBS Lett. | volume = 306 | issue = 2–3 | pages = 169–172 | year = 1992 | pmid = 1633872 | doi = 10.1016/0014-5793(92)80992-P }}
*{{cite journal | author=Hsu JC, Bravo R, Taub R |title=Interactions among LRF-1, JunB, c-Jun, and c-Fos define a regulatory program in the G1 phase of liver regeneration. |journal=Mol. Cell. Biol. |volume=12 |issue= 10 |pages= 4654-65 |year= 1992 |pmid= 1406655 |doi=  }}
*{{cite journal |vauthors=Mollinedo F, Vaquerizo MJ, Naranjo JR | title = Expression of c-jun, jun B and jun D proto-oncogenes in human peripheral-blood granulocytes | journal = Biochem. J. | volume = 273(Pt 2) | issue =  | pages = 477–9 | year = 1991 | pmid = 1899335 | pmc = 1149869 | doi =  }}
*{{cite journal | author=Zafarullah M, Martel-Pelletier J, Cloutier JM, ''et al.'' |title=Expression of c-fos, c-jun, jun-B, metallothionein and metalloproteinase genes in human chondrocyte. |journal=FEBS Lett. |volume=306 |issue= 2-3 |pages= 169-72 |year= 1992 |pmid= 1633872 |doi= }}
*{{cite journal |vauthors=Nomura N, Ide M, Sasamoto S, Matsui M, Date T, Ishizaki R | title = Isolation of human cDNA clones of jun-related genes, jun-B and jun-D | journal = Nucleic Acids Res. | volume = 18 | issue = 10 | pages = 3047–3048 | year = 1990 | pmid = 2112242 | pmc = 330838 | doi = 10.1093/nar/18.10.3047 }}
*{{cite journal | author=Mollinedo F, Vaquerizo MJ, Naranjo JR |title=Expression of c-jun, jun B and jun D proto-oncogenes in human peripheral-blood granulocytes. |journal=Biochem. J. |volume=273(Pt 2) |issue=  |pages= 477-9 |year= 1991 |pmid= 1899335 |doi=  }}
*{{cite journal |vauthors=Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–174 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Nomura N, Ide M, Sasamoto S, ''et al.'' |title=Isolation of human cDNA clones of jun-related genes, jun-B and jun-D. |journal=Nucleic Acids Res. |volume=18 |issue= 10 |pages= 3047-8 |year= 1990 |pmid= 2112242 |doi= }}
*{{cite journal |vauthors=Trask B, Fertitta A, Christensen M, Youngblom J, Bergmann A, Copeland A, de Jong P, Mohrenweiser H, Olsen A, Carrano A | title = Fluorescence in situ hybridization mapping of human chromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA markers | journal = Genomics | volume = 15 | issue = 1 | pages = 133–145 | year = 1993 | pmid = 8432525 | doi = 10.1006/geno.1993.1021 }}
*{{cite journal | author=Schütte J, Viallet J, Nau M, ''et al.'' |title=jun-B inhibits and c-fos stimulates the transforming and trans-activating activities of c-jun. |journal=Cell |volume=59 |issue= 6 |pages= 987-97 |year= 1990 |pmid= 2513129 |doi= }}
*{{cite journal |vauthors=Phinney DG, Tseng SW, Ryder K | title = Complex genetic organization of junB: multiple blocks of flanking evolutionarily conserved sequence at the murine and human junB loci | journal = Genomics | volume = 28 | issue = 2 | pages = 228–234 | year = 1996 | pmid = 8530030 | doi = 10.1006/geno.1995.1135 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
*{{cite journal |vauthors=Dorsey MJ, Tae HJ, Sollenberger KG, Mascarenhas NT, Johansen LM, Taparowsky EJ | title = B-ATF: a novel human bZIP protein that associates with members of the AP-1 transcription factor family | journal = Oncogene | volume = 11 | issue = 11 | pages = 2255–65 | year = 1996 | pmid = 8570175 | doi = }}
*{{cite journal | author=Trask B, Fertitta A, Christensen M, ''et al.'' |title=Fluorescence in situ hybridization mapping of human chromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA markers. |journal=Genomics |volume=15 |issue= 1 |pages= 133-45 |year= 1993 |pmid= 8432525 |doi= }}
*{{cite journal |vauthors=Neyns B, Vermeij J, Bourgain C, Vandamme B, Amfo K, Lissens W, DeSutter P, Hooghe-Peters E, DeGrève J | title = Expression of the jun family of genes in human ovarian cancer and normal ovarian surface epithelium | journal = Oncogene | volume = 12 | issue = 6 | pages = 1247–57 | year = 1996 | pmid = 8649827 | doi = }}
*{{cite journal | author=Phinney DG, Tseng SW, Ryder K |title=Complex genetic organization of junB: multiple blocks of flanking evolutionarily conserved sequence at the murine and human junB loci. |journal=Genomics |volume=28 |issue= 2 |pages= 228-34 |year= 1996 |pmid= 8530030 |doi= 10.1006/geno.1995.1135 }}
*{{cite journal |vauthors=Mendelson KG, Contois LR, Tevosian SG, Davis RJ, Paulson KE | title = Independent regulation of JNK/p38 mitogen-activated protein kinases by metabolic oxidative stress in the liver | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 93 | issue = 23 | pages = 12908–12913 | year = 1996 | pmid = 8917518 | pmc = 24019 | doi = 10.1073/pnas.93.23.12908 }}
*{{cite journal | author=Dorsey MJ, Tae HJ, Sollenberger KG, ''et al.'' |title=B-ATF: a novel human bZIP protein that associates with members of the AP-1 transcription factor family. |journal=Oncogene |volume=11 |issue= 11 |pages= 2255-65 |year= 1996 |pmid= 8570175 |doi= }}
*{{cite journal |vauthors=Aronheim A, Zandi E, Hennemann H, Elledge SJ, Karin M | title = Isolation of an AP-1 repressor by a novel method for detecting protein-protein interactions | journal = Mol. Cell. Biol. | volume = 17 | issue = 6 | pages = 3094–102 | year = 1997 | pmid = 9154808 | pmc = 232162 | doi =  10.1128/mcb.17.6.3094}}
*{{cite journal | author=Neyns B, Katesuwanasing , Vermeij J, ''et al.'' |title=Expression of the jun family of genes in human ovarian cancer and normal ovarian surface epithelium. |journal=Oncogene |volume=12 |issue= 6 |pages= 1247-57 |year= 1996 |pmid= 8649827 |doi= }}
*{{cite journal |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–156 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Mendelson KG, Contois LR, Tevosian SG, ''et al.'' |title=Independent regulation of JNK/p38 mitogen-activated protein kinases by metabolic oxidative stress in the liver. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 23 |pages= 12908-13 |year= 1996 |pmid= 8917518 |doi=  }}
*{{cite journal |vauthors=Fuchs SY, Xie B, Adler V, Fried VA, Davis RJ, Ronai Z | title = c-Jun NH2-terminal kinases target the ubiquitination of their associated transcription factors | journal = J. Biol. Chem. | volume = 272 | issue = 51 | pages = 32163–32168 | year = 1998 | pmid = 9405416 | doi = 10.1074/jbc.272.51.32163 }}
*{{cite journal | author=Aronheim A, Zandi E, Hennemann H, ''et al.'' |title=Isolation of an AP-1 repressor by a novel method for detecting protein-protein interactions. |journal=Mol. Cell. Biol. |volume=17 |issue= 6 |pages= 3094-102 |year= 1997 |pmid= 9154808 |doi= }}
*{{cite journal |vauthors=Venugopal R, Jaiswal AK | title = Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes | journal = Oncogene | volume = 17 | issue = 24 | pages = 3145–3156 | year = 1999 | pmid = 9872330 | doi = 10.1038/sj.onc.1202237 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal |vauthors=Li B, Tournier C, Davis RJ, Flavell RA | title = Regulation of IL-4 expression by the transcription factor JunB during T helper cell differentiation | journal = EMBO J. | volume = 18 | issue = 2 | pages = 420–432 | year = 1999 | pmid = 9889198 | pmc = 1171136 | doi = 10.1093/emboj/18.2.420 }}
*{{cite journal | author=Fuchs SY, Xie B, Adler V, ''et al.'' |title=c-Jun NH2-terminal kinases target the ubiquitination of their associated transcription factors. |journal=J. Biol. Chem. |volume=272 |issue= 51 |pages= 32163-8 |year= 1998 |pmid= 9405416 |doi= }}
*{{cite journal |vauthors=Liberati NT, Datto MB, Frederick JP, Shen X, Wong C, Rougier-Chapman EM, Wang XF | title = Smads bind directly to the Jun family of AP-1 transcription factors | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 96 | issue = 9 | pages = 4844–4849 | year = 1999 | pmid = 10220381 | pmc = 21779 | doi = 10.1073/pnas.96.9.4844 }}
*{{cite journal | author=Venugopal R, Jaiswal AK |title=Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes. |journal=Oncogene |volume=17 |issue= 24 |pages= 3145-56 |year= 1999 |pmid= 9872330 |doi= 10.1038/sj.onc.1202237 }}
*{{cite journal |vauthors=Chen P, Flory E, Avots A, Jordan BW, Kirchhoff F, Ludwig S, Rapp UR | title = Transactivation of naturally occurring HIV-1 long terminal repeats by the JNK signaling pathway. The most frequent naturally occurring length polymorphism sequence introduces a novel binding site for AP-1 factors | journal = J. Biol. Chem. | volume = 275 | issue = 27 | pages = 20382–20390 | year = 2000 | pmid = 10764760 | doi = 10.1074/jbc.M001149200 }}
*{{cite journal | author=Li B, Tournier C, Davis RJ, Flavell RA |title=Regulation of IL-4 expression by the transcription factor JunB during T helper cell differentiation. |journal=EMBO J. |volume=18 |issue= 2 |pages= 420-32 |year= 1999 |pmid= 9889198 |doi= 10.1093/emboj/18.2.420 }}
*{{cite journal |vauthors=Echlin DR, Tae HJ, Mitin N, Taparowsky EJ | title = B-ATF functions as a negative regulator of AP-1 mediated transcription and blocks cellular transformation by Ras and Fos | journal = Oncogene | volume = 19 | issue = 14 | pages = 1752–1763 | year = 2000 | pmid = 10777209 | doi = 10.1038/sj.onc.1203491 }}
*{{cite journal | author=Liberati NT, Datto MB, Frederick JP, ''et al.'' |title=Smads bind directly to the Jun family of AP-1 transcription factors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 9 |pages= 4844-9 |year= 1999 |pmid= 10220381 |doi= }}
*{{cite journal |vauthors=Verrecchia F, Pessah M, Atfi A, Mauviel A | title = Tumor necrosis factor-alpha inhibits transforming growth factor-beta /Smad signaling in human dermal fibroblasts via AP-1 activation | journal = J. Biol. Chem. | volume = 275 | issue = 39 | pages = 30226–30231 | year = 2000 | pmid = 10903323 | doi = 10.1074/jbc.M005310200 | url = http://www.hal.inserm.fr/inserm-00150046 }}
*{{cite journal | author=Chen P, Flory E, Avots A, ''et al.'' |title=Transactivation of naturally occurring HIV-1 long terminal repeats by the JNK signaling pathway. The most frequent naturally occurring length polymorphism sequence introduces a novel binding site for AP-1 factors. |journal=J. Biol. Chem. |volume=275 |issue= 27 |pages= 20382-90 |year= 2000 |pmid= 10764760 |doi= 10.1074/jbc.M001149200 }}
*{{cite journal | author=Echlin DR, Tae HJ, Mitin N, Taparowsky EJ |title=B-ATF functions as a negative regulator of AP-1 mediated transcription and blocks cellular transformation by Ras and Fos. |journal=Oncogene |volume=19 |issue= 14 |pages= 1752-63 |year= 2000 |pmid= 10777209 |doi= 10.1038/sj.onc.1203491 }}
*{{cite journal  | author=Verrecchia F, Pessah M, Atfi A, Mauviel A |title=Tumor necrosis factor-alpha inhibits transforming growth factor-beta /Smad signaling in human dermal fibroblasts via AP-1 activation. |journal=J. Biol. Chem. |volume=275 |issue= 39 |pages= 30226-31 |year= 2000 |pmid= 10903323 |doi= 10.1074/jbc.M005310200 }}
}}
{{refend}}
{{refend}}


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{{NLM content}}
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{{Transcription factors|g1}}
[[Category:Transcription factors]]
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{{Transcription factors}}
[[Category:Transcription factors]]
{{WikiDoc Sources}}

Latest revision as of 12:40, 4 November 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Transcription factor jun-B is a protein that in humans is encoded by the JUNB gene.[1][2] Transcription factor jun-B is a transcription factor involved in regulating gene activity following the primary growth factor response. It binds to the DNA sequence 5'-TGA[CG]TCA-3'.

Interactions

JUNB has been shown to interact with

See also

References

  1. ↑ Schütte J, Viallet J, Nau M, Segal S, Fedorko J, Minna J (Feb 1990). "jun-B inhibits and c-fos stimulates the transforming and trans-activating activities of c-jun". Cell. 59 (6): 987–997. doi:10.1016/0092-8674(89)90755-1. PMID 2513129.
  2. ↑ "Entrez Gene: JUNB jun B proto-oncogene".
  3. ↑ Hu YF, Li R (Jun 2002). "JunB potentiates function of BRCA1 activation domain 1 (AD1) through a coiled-coil-mediated interaction". Genes Dev. 16 (12): 1509–17. doi:10.1101/gad.995502. PMC 186344. PMID 12080089.
  4. ↑ Liberati NT, Datto MB, Frederick JP, Shen X, Wong C, Rougier-Chapman EM, Wang XF (Apr 1999). "Smads bind directly to the Jun family of AP-1 transcription factors". Proc. Natl. Acad. Sci. U.S.A. 96 (9): 4844–9. doi:10.1073/pnas.96.9.4844. PMC 21779. PMID 10220381.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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