USP8: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{reflist}} +{{reflist|2}}, -<references /> +{{reflist|2}}, -{{WikiDoc Cardiology Network Infobox}} +))
 
m (1 revision imported)
 
(2 intermediate revisions by 2 users not shown)
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Ubiquitin carboxyl-terminal hydrolase 8''' is an [[enzyme]] that in humans is encoded by the ''USP8'' [[gene]].<ref name="pmid12838346">{{cite journal |vauthors=Puente XS, Sanchez LM, Overall CM, Lopez-Otin C | title = Human and mouse proteases: a comparative genomic approach | journal = Nat Rev Genet | volume = 4 | issue = 7 | pages = 544–58 |date=July 2003 | pmid = 12838346 | pmc =  | doi = 10.1038/nrg1111 }}</ref><ref name="pmid9582025">{{cite journal |vauthors=Janssen JW, Schleithoff L, Bartram CR, Schulz AS | title = An oncogenic fusion product of the phosphatidylinositol 3-kinase p85beta subunit and HUMORF8, a putative deubiquitinating enzyme | journal = Oncogene | volume = 16 | issue = 13 | pages = 1767–72 |date=May 1998 | pmid = 9582025 | pmc =  | doi = 10.1038/sj.onc.1201695 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: USP8 ubiquitin specific peptidase 8| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9101| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
 
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_USP8_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1whb.
| PDB = {{PDB2|1whb}}, {{PDB2|2a9u}}, {{PDB2|2gfo}}, {{PDB2|2gwf}}
| Name = Ubiquitin specific peptidase 8
| HGNCid = 12631
| Symbol = USP8
| AltSymbols =; FLJ34456; HumORF8; KIAA0055; MGC129718; UBPY
| OMIM = 603158
| ECnumber =
| Homologene = 3782
| MGIid = 1934029
  | Function = {{GNF_GO|id=GO:0004197 |text = cysteine-type endopeptidase activity}} {{GNF_GO|id=GO:0004221 |text = ubiquitin thiolesterase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}}
| Process = {{GNF_GO|id=GO:0006511 |text = ubiquitin-dependent protein catabolic process}} {{GNF_GO|id=GO:0006512 |text = ubiquitin cycle}} {{GNF_GO|id=GO:0007265 |text = Ras protein signal transduction}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9101
    | Hs_Ensembl =
    | Hs_RefseqProtein = NP_005145
    | Hs_RefseqmRNA = NM_005154
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr =
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 84092
    | Mm_Ensembl = ENSMUSG00000027363
    | Mm_RefseqmRNA = NM_019729
    | Mm_RefseqProtein = NP_062703
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 126398804
    | Mm_GenLoc_end = 126450738
    | Mm_Uniprot = Q3TQM7
  }}
}}
'''Ubiquitin specific peptidase 8''', also known as '''USP8''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: USP8 ubiquitin specific peptidase 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9101| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Line 52: Line 7:
| summary_text =  
| summary_text =  
}}
}}
==Interactions==
USP8 has been shown to [[Protein-protein interaction|interact]] with [[RNF41]]<ref name=pmid15314180>{{cite journal |last=Wu |first=Xiuli |authorlink= |author2=Yen Lily |author3=Irwin Lisa |author4=Sweeney Colleen |author5=Carraway Kermit L  |date=September 2004  |title=Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8 |journal=Mol. Cell. Biol. |volume=24 |issue=17 |pages=7748–57 |publisher= |location = United States| issn = 0270-7306| pmid = 15314180 |doi = 10.1128/MCB.24.17.7748-7757.2004 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=506982 }}</ref> and [[STAM2]].<ref name=pmid13129930>{{cite journal |last=Kaneko |first=Tomonori |authorlink= |author2=Kumasaka Takashi |author3=Ganbe Tadashi |author4=Sato Takao |author5=Miyazawa Keiji |author6=Kitamura Naomi |author7=Tanaka Nobuo  |date=November 2003  |title=Structural insight into modest binding of a non-PXXP ligand to the signal transducing adaptor molecule-2 Src homology 3 domain |journal=J. Biol. Chem. |volume=278 |issue=48 |pages=48162–8 |publisher= |location = United States| issn = 0021-9258| pmid = 13129930 |doi = 10.1074/jbc.M306677200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid10982817>{{cite journal |last=Kato |first=M |authorlink= |author2=Miyazawa K |author3=Kitamura N  |date=December 2000  |title=A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP |journal=J. Biol. Chem. |volume=275 |issue=48 |pages=37481–7 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 10982817 |doi = 10.1074/jbc.M007251200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=D'Andrea A, Pellman D |title=Deubiquitinating enzymes: a new class of biological regulators. |journal=Crit. Rev. Biochem. Mol. Biol. |volume=33 |issue= 5 |pages= 337-52 |year= 1999 |pmid= 9827704 |doi=  }}
*{{cite journal  |vauthors=D'Andrea A, Pellman D |title=Deubiquitinating enzymes: a new class of biological regulators. |journal=Crit. Rev. Biochem. Mol. Biol. |volume=33 |issue= 5 |pages= 337–52 |year= 1999 |pmid= 9827704 |doi=10.1080/10409239891204251  }}
*{{cite journal  | author=Puente XS, Sánchez LM, Overall CM, López-Otín C |title=Human and mouse proteases: a comparative genomic approach. |journal=Nat. Rev. Genet. |volume=4 |issue= 7 |pages= 544-58 |year= 2003 |pmid= 12838346 |doi= 10.1038/nrg1111 }}
*{{cite journal   |vauthors=Nomura N, Nagase T, Miyajima N, etal |title=Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. |journal=DNA Res. |volume=1 |issue= 5 |pages= 223–9 |year= 1995 |pmid= 7584044 |doi=10.1093/dnares/1.5.223  }}
*{{cite journal | author=Nomura N, Nagase T, Miyajima N, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. |journal=DNA Res. |volume=1 |issue= 5 |pages= 223-9 |year= 1995 |pmid= 7584044 |doi=  }}
*{{cite journal   |vauthors=Naviglio S, Mattecucci C, Matoskova B, etal |title=UBPY: a growth-regulated human ubiquitin isopeptidase. |journal=EMBO J. |volume=17 |issue= 12 |pages= 3241–50 |year= 1998 |pmid= 9628861 |doi= 10.1093/emboj/17.12.3241 | pmc=1170662 }}
*{{cite journal  | author=Janssen JW, Schleithoff L, Bartram CR, Schulz AS |title=An oncogenic fusion product of the phosphatidylinositol 3-kinase p85beta subunit and HUMORF8, a putative deubiquitinating enzyme. |journal=Oncogene |volume=16 |issue= 13 |pages= 1767-72 |year= 1998 |pmid= 9582025 |doi= 10.1038/sj.onc.1201695 }}
*{{cite journal  |vauthors=Kato M, Miyazawa K, Kitamura N |title=A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP. |journal=J. Biol. Chem. |volume=275 |issue= 48 |pages= 37481–7 |year= 2001 |pmid= 10982817 |doi= 10.1074/jbc.M007251200 }}
*{{cite journal | author=Naviglio S, Mattecucci C, Matoskova B, ''et al.'' |title=UBPY: a growth-regulated human ubiquitin isopeptidase. |journal=EMBO J. |volume=17 |issue= 12 |pages= 3241-50 |year= 1998 |pmid= 9628861 |doi= 10.1093/emboj/17.12.3241 }}
*{{cite journal   |vauthors=Gnesutta N, Ceriani M, Innocenti M, etal |title=Cloning and characterization of mouse UBPy, a deubiquitinating enzyme that interacts with the ras guanine nucleotide exchange factor CDC25(Mm)/Ras-GRF1. |journal=J. Biol. Chem. |volume=276 |issue= 42 |pages= 39448–54 |year= 2001 |pmid= 11500497 |doi= 10.1074/jbc.M103454200 }}
*{{cite journal  | author=Kato M, Miyazawa K, Kitamura N |title=A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP. |journal=J. Biol. Chem. |volume=275 |issue= 48 |pages= 37481-7 |year= 2001 |pmid= 10982817 |doi= 10.1074/jbc.M007251200 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M }}
*{{cite journal | author=Gnesutta N, Ceriani M, Innocenti M, ''et al.'' |title=Cloning and characterization of mouse UBPy, a deubiquitinating enzyme that interacts with the ras guanine nucleotide exchange factor CDC25(Mm)/Ras-GRF1. |journal=J. Biol. Chem. |volume=276 |issue= 42 |pages= 39448-54 |year= 2001 |pmid= 11500497 |doi= 10.1074/jbc.M103454200 }}
*{{cite journal   |vauthors=Kaneko T, Kumasaka T, Ganbe T, etal |title=Structural insight into modest binding of a non-PXXP ligand to the signal transducing adaptor molecule-2 Src homology 3 domain. |journal=J. Biol. Chem. |volume=278 |issue= 48 |pages= 48162–8 |year= 2004 |pmid= 13129930 |doi= 10.1074/jbc.M306677200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Soares L, Seroogy C, Skrenta H, etal |title=Two isoforms of otubain 1 regulate T cell anergy via GRAIL. |journal=Nat. Immunol. |volume=5 |issue= 1 |pages= 45–54 |year= 2004 |pmid= 14661020 |doi= 10.1038/ni1017 }}
*{{cite journal | author=Kaneko T, Kumasaka T, Ganbe T, ''et al.'' |title=Structural insight into modest binding of a non-PXXP ligand to the signal transducing adaptor molecule-2 Src homology 3 domain. |journal=J. Biol. Chem. |volume=278 |issue= 48 |pages= 48162-8 |year= 2004 |pmid= 13129930 |doi= 10.1074/jbc.M306677200 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Soares L, Seroogy C, Skrenta H, ''et al.'' |title=Two isoforms of otubain 1 regulate T cell anergy via GRAIL. |journal=Nat. Immunol. |volume=5 |issue= 1 |pages= 45-54 |year= 2004 |pmid= 14661020 |doi= 10.1038/ni1017 }}
*{{cite journal   |vauthors=Wu X, Yen L, Irwin L, etal |title=Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8. |journal=Mol. Cell. Biol. |volume=24 |issue= 17 |pages= 7748–57 |year= 2004 |pmid= 15314180 |doi= 10.1128/MCB.24.17.7748-7757.2004 | pmc=506982 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  |vauthors=Berruti G, Martegani E |title=The deubiquitinating enzyme mUBPy interacts with the sperm-specific molecular chaperone MSJ-1: the relation with the proteasome, acrosome, and centrosome in mouse male germ cells. |journal=Biol. Reprod. |volume=72 |issue= 1 |pages= 14–21 |year= 2005 |pmid= 15342353 |doi= 10.1095/biolreprod.104.030866 }}
*{{cite journal | author=Wu X, Yen L, Irwin L, ''et al.'' |title=Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8. |journal=Mol. Cell. Biol. |volume=24 |issue= 17 |pages= 7748-57 |year= 2004 |pmid= 15314180 |doi= 10.1128/MCB.24.17.7748-7757.2004 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal  | author=Berruti G, Martegani E |title=The deubiquitinating enzyme mUBPy interacts with the sperm-specific molecular chaperone MSJ-1: the relation with the proteasome, acrosome, and centrosome in mouse male germ cells. |journal=Biol. Reprod. |volume=72 |issue= 1 |pages= 14-21 |year= 2005 |pmid= 15342353 |doi= 10.1095/biolreprod.104.030866 }}
*{{cite journal   |vauthors=Benzinger A, Muster N, Koch HB, etal |title=Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer. |journal=Mol. Cell. Proteomics |volume=4 |issue= 6 |pages= 785–95 |year= 2005 |pmid= 15778465 |doi= 10.1074/mcp.M500021-MCP200 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Row PE, Prior IA, McCullough J, etal |title=The ubiquitin isopeptidase UBPY regulates endosomal ubiquitin dynamics and is essential for receptor down-regulation. |journal=J. Biol. Chem. |volume=281 |issue= 18 |pages= 12618–24 |year= 2006 |pmid= 16520378 |doi= 10.1074/jbc.M512615200 }}
*{{cite journal | author=Benzinger A, Muster N, Koch HB, ''et al.'' |title=Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer. |journal=Mol. Cell Proteomics |volume=4 |issue= 6 |pages= 785-95 |year= 2005 |pmid= 15778465 |doi= 10.1074/mcp.M500021-MCP200 }}
*{{cite journal   |vauthors=Mizuno E, Kobayashi K, Yamamoto A, etal |title=A deubiquitinating enzyme UBPY regulates the level of protein ubiquitination on endosomes. |journal=Traffic |volume=7 |issue= 8 |pages= 1017–31 |year= 2006 |pmid= 16771824 |doi= 10.1111/j.1600-0854.2006.00452.x }}
*{{cite journal | author=Row PE, Prior IA, McCullough J, ''et al.'' |title=The ubiquitin isopeptidase UBPY regulates endosomal ubiquitin dynamics and is essential for receptor down-regulation. |journal=J. Biol. Chem. |volume=281 |issue= 18 |pages= 12618-24 |year= 2006 |pmid= 16520378 |doi= 10.1074/jbc.M512615200 }}
*{{cite journal   |vauthors=Avvakumov GV, Walker JR, Xue S, etal |title=Amino-terminal dimerization, NRDP1-rhodanese interaction, and inhibited catalytic domain conformation of the ubiquitin-specific protease 8 (USP8). |journal=J. Biol. Chem. |volume=281 |issue= 49 |pages= 38061–70 |year= 2007 |pmid= 17035239 |doi= 10.1074/jbc.M606704200 }}
*{{cite journal | author=Mizuno E, Kobayashi K, Yamamoto A, ''et al.'' |title=A deubiquitinating enzyme UBPY regulates the level of protein ubiquitination on endosomes. |journal=Traffic |volume=7 |issue= 8 |pages= 1017-31 |year= 2006 |pmid= 16771824 |doi= 10.1111/j.1600-0854.2006.00452.x }}
*{{cite journal | author=Avvakumov GV, Walker JR, Xue S, ''et al.'' |title=Amino-terminal dimerization, NRDP1-rhodanese interaction, and inhibited catalytic domain conformation of the ubiquitin-specific protease 8 (USP8). |journal=J. Biol. Chem. |volume=281 |issue= 49 |pages= 38061-70 |year= 2007 |pmid= 17035239 |doi= 10.1074/jbc.M606704200 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=9101}}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


{{protein-stub}}
{{protein-stub}}
{{WikiDoc Sources}}

Latest revision as of 12:44, 9 January 2019

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Ubiquitin carboxyl-terminal hydrolase 8 is an enzyme that in humans is encoded by the USP8 gene.[1][2][3]


Interactions

USP8 has been shown to interact with RNF41[4] and STAM2.[5][6]

References

  1. ↑ Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (July 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet. 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346.
  2. ↑ Janssen JW, Schleithoff L, Bartram CR, Schulz AS (May 1998). "An oncogenic fusion product of the phosphatidylinositol 3-kinase p85beta subunit and HUMORF8, a putative deubiquitinating enzyme". Oncogene. 16 (13): 1767–72. doi:10.1038/sj.onc.1201695. PMID 9582025.
  3. ↑ "Entrez Gene: USP8 ubiquitin specific peptidase 8".
  4. ↑ Wu, Xiuli; Yen Lily; Irwin Lisa; Sweeney Colleen; Carraway Kermit L (September 2004). "Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8". Mol. Cell. Biol. United States. 24 (17): 7748–57. doi:10.1128/MCB.24.17.7748-7757.2004. ISSN 0270-7306. PMC 506982. PMID 15314180.
  5. ↑ Kaneko, Tomonori; Kumasaka Takashi; Ganbe Tadashi; Sato Takao; Miyazawa Keiji; Kitamura Naomi; Tanaka Nobuo (November 2003). "Structural insight into modest binding of a non-PXXP ligand to the signal transducing adaptor molecule-2 Src homology 3 domain". J. Biol. Chem. United States. 278 (48): 48162–8. doi:10.1074/jbc.M306677200. ISSN 0021-9258. PMID 13129930.
  6. ↑ Kato, M; Miyazawa K; Kitamura N (December 2000). "A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP". J. Biol. Chem. UNITED STATES. 275 (48): 37481–7. doi:10.1074/jbc.M007251200. ISSN 0021-9258. PMID 10982817.

Further reading



Retrieved from "https://www.wikidoc.org/index.php?title=USP8&oldid=1519517"