Peutz-Jeghers syndrome secondary prevention: Difference between revisions
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{{CMG}}; {{AE}} {{HQ}} | {{CMG}}; {{AE}} {{HQ}} | ||
==Overview== | ==Overview== | ||
Secondary prevention strategies to detect intestinal and extraintestinal malignancies in Peutz-Jeghers syndrome include [[enteroscopy]] and [[colonoscopy]]. | Secondary prevention strategies to detect intestinal and extraintestinal malignancies in Peutz-Jeghers syndrome include performing [[enteroscopy]] and [[colonoscopy]] at periodic intervals. | ||
==Secondary Prevention== | ==Secondary Prevention== | ||
At time of diagnosis, screening for cancerous lesions among patients with Peutz-Jeghers syndrome include the following:<ref name="SyngalBrand2015">{{cite journal|last1=Syngal|first1=Sapna|last2=Brand|first2=Randall E|last3=Church|first3=James M|last4=Giardiello|first4=Francis M|last5=Hampel|first5=Heather L|last6=Burt|first6=Randall W|title=ACG Clinical Guideline: Genetic Testing and Management of Hereditary Gastrointestinal Cancer Syndromes|journal=The American Journal of Gastroenterology|volume=110|issue=2|year=2015|pages=223–262|issn=0002-9270|doi=10.1038/ajg.2014.435}}</ref><ref> Peutz-Jeghers syndrome https://online.epocrates.com/u/29441128/Peutz-Jeghers+syndrome</ref> | At time of diagnosis, screening for cancerous lesions among patients with Peutz-Jeghers syndrome include the following:<ref name="SyngalBrand2015">{{cite journal|last1=Syngal|first1=Sapna|last2=Brand|first2=Randall E|last3=Church|first3=James M|last4=Giardiello|first4=Francis M|last5=Hampel|first5=Heather L|last6=Burt|first6=Randall W|title=ACG Clinical Guideline: Genetic Testing and Management of Hereditary Gastrointestinal Cancer Syndromes|journal=The American Journal of Gastroenterology|volume=110|issue=2|year=2015|pages=223–262|issn=0002-9270|doi=10.1038/ajg.2014.435}}</ref><ref>Peutz-Jeghers syndrome https://online.epocrates.com/u/29441128/Peutz-Jeghers+syndrome</ref> | ||
*Small bowel video capsule endoscopy (every 3 years) | *[[Small bowel]] video [[capsule endoscopy]] (every 3 years) | ||
*Stomach [[ | *[[Stomach]] [[esophagogastroduodenoscopy]] (every 3 years) | ||
*[[Colonoscopy]] (every 3 years) | *[[Colonoscopy]] (every 3 years) | ||
*Pancreas (every 1-2 years) | *[[Pancreas]] (every 1-2 years) | ||
**[[Endoscopic ultrasound]] OR | **[[Endoscopic ultrasound]] OR | ||
**[[Magnetic resonance cholangiopancreatography]] (MRCP) | **[[Magnetic resonance cholangiopancreatography]] (MRCP) | ||
*Abdominal [[CT]] | *Abdominal [[CT]] | ||
*[[Pelvic ultrasound]] (annually) | *[[Pelvic ultrasound]] (annually) | ||
*Testicular exam (annually) | *[[Testicular]] exam (annually) | ||
**If abnormalities palpable perform an ultrasound | **If abnormalities palpable perform an [[ultrasound]] | ||
*[[Mammography]] starting at age 25 (annually) | *[[Mammography]] starting at age 25 (annually) | ||
*Endometrial pelvic exam and ultrasound (annually) | *[[Endometrial]] [[pelvic exam]] and [[ultrasound]] (annually) | ||
*Cervical Papanicolaou test ([[Pap test]]) (annually) | *[[Cervical]] [[Pap test|Papanicolaou test]] ([[Pap test]]) (annually) | ||
*Physical examination that includes evaluation of the [[breasts]], [[abdomen]], [[pelvis]], and [[testes]] should be performed by a physician (annually) | *Physical examination that includes evaluation of the [[breasts]], [[abdomen]], [[pelvis]], and [[testes]] should be performed by a physician (annually) | ||
*Complete blood count ([[CBC]]) to check for anemia should be done (annually) | *[[Complete blood count]] ([[CBC]]) to check for [[anemia]] should be done (annually) | ||
== References == | == References == | ||
Latest revision as of 15:09, 21 December 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Hamid Qazi, MD, BSc [2]
Overview
Secondary prevention strategies to detect intestinal and extraintestinal malignancies in Peutz-Jeghers syndrome include performing enteroscopy and colonoscopy at periodic intervals.
Secondary Prevention
At time of diagnosis, screening for cancerous lesions among patients with Peutz-Jeghers syndrome include the following:[1][2]
- Small bowel video capsule endoscopy (every 3 years)
- Stomach esophagogastroduodenoscopy (every 3 years)
- Colonoscopy (every 3 years)
- Pancreas (every 1-2 years)
- Abdominal CT
- Pelvic ultrasound (annually)
- Testicular exam (annually)
- If abnormalities palpable perform an ultrasound
- Mammography starting at age 25 (annually)
- Endometrial pelvic exam and ultrasound (annually)
- Cervical Papanicolaou test (Pap test) (annually)
- Physical examination that includes evaluation of the breasts, abdomen, pelvis, and testes should be performed by a physician (annually)
- Complete blood count (CBC) to check for anemia should be done (annually)
References
- ↑ Syngal, Sapna; Brand, Randall E; Church, James M; Giardiello, Francis M; Hampel, Heather L; Burt, Randall W (2015). "ACG Clinical Guideline: Genetic Testing and Management of Hereditary Gastrointestinal Cancer Syndromes". The American Journal of Gastroenterology. 110 (2): 223–262. doi:10.1038/ajg.2014.435. ISSN 0002-9270.
- ↑ Peutz-Jeghers syndrome https://online.epocrates.com/u/29441128/Peutz-Jeghers+syndrome