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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''GRB2-related adapter protein 2''' also known as GRB2-related adaptor downstream of Shc (GADS) is a 37 [[Atomic mass unit|kDa]] [[protein]] that in humans is encoded by the ''GRAP2'' [[gene]].<ref name="pmid9878555">{{cite journal | vauthors = Qiu M, Hua S, Agrawal M, Li G, Cai J, Chan E, Zhou H, Luo Y, Liu M | title = Molecular cloning and expression of human grap-2, a novel leukocyte-specific SH2- and SH3-containing adaptor-like protein that binds to gab-1 | journal = Biochemical and Biophysical Research Communications | volume = 253 | issue = 2 | pages = 443–7 | date = Dec 1998 | pmid = 9878555 | pmc =  | doi = 10.1006/bbrc.1998.9795 }}</ref><ref name="pmid10224278">{{cite journal | vauthors = Asada H, Ishii N, Sasaki Y, Endo K, Kasai H, Tanaka N, Takeshita T, Tsuchiya S, Konno T, Sugamura K | title = Grf40, A novel Grb2 family member, is involved in T cell signaling through interaction with SLP-76 and LAT | journal = The Journal of Experimental Medicine | volume = 189 | issue = 9 | pages = 1383–90 | date = May 1999 | pmid = 10224278 | pmc = 2193052 | doi = 10.1084/jem.189.9.1383 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GRAP2 GRB2-related adaptor protein 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9402| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_GRAP2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1h3h.
| PDB = {{PDB2|1h3h}}, {{PDB2|1oeb}}, {{PDB2|1r1p}}, {{PDB2|1r1q}}, {{PDB2|1r1s}}, {{PDB2|1uti}}, {{PDB2|2d0n}}
| Name = GRB2-related adaptor protein 2
| HGNCid = 4563
| Symbol = GRAP2
| AltSymbols =; P38; GADS; GRAP-2; GRB2L; GRBLG; GRID; GRPL; GrbX; Grf40; Mona
| OMIM = 604518
| ECnumber = 
| Homologene = 21007
| MGIid = 1333842
| GeneAtlas_image1 = PBB_GE_GRAP2_208406_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005070 |text = SH3/SH2 adaptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0007265 |text = Ras protein signal transduction}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0019735 |text = antimicrobial humoral response}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9402
    | Hs_Ensembl = ENSG00000100351
    | Hs_RefseqProtein = NP_004801
    | Hs_RefseqmRNA = NM_004810
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 22
    | Hs_GenLoc_start = 38627080
    | Hs_GenLoc_end = 38698204
    | Hs_Uniprot = O75791
    | Mm_EntrezGene = 17444
    | Mm_Ensembl = ENSMUSG00000042351
    | Mm_RefseqmRNA = XM_001002330
    | Mm_RefseqProtein = XP_001002330
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 15
    | Mm_GenLoc_start = 80399849
    | Mm_GenLoc_end = 80476017
    | Mm_Uniprot = Q3U0E8
  }}
}}
'''GRB2-related adaptor protein 2''', also known as '''GRAP2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GRAP2 GRB2-related adaptor protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9402| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a member of the [[GRB2]]/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Transcript variants utilizing alternative polyA sites exist.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Transcript variants utilizing alternative polyA sites exist.<ref name="entrez">{{cite web | title = Entrez Gene: GRAP2 GRB2-related adaptor protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9402| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
GRAP2 has been shown to [[Protein-protein interaction|interact]] with:
{{div col|colwidth=20em}}
* [[CCNDBP1]],<ref name = pmid10801854>{{cite journal | vauthors = Xia C, Bao Z, Tabassam F, Ma W, Qiu M, Hua S, Liu M | title = GCIP, a novel human grap2 and cyclin D interacting protein, regulates E2F-mediated transcriptional activity | journal = The Journal of Biological Chemistry | volume = 275 | issue = 27 | pages = 20942–8 | date = Jul 2000 | pmid = 10801854 | doi = 10.1074/jbc.M002598200 }}</ref>
* [[CD28]],<ref name = pmid10820259>{{cite journal | vauthors = Ellis JH, Ashman C, Burden MN, Kilpatrick KE, Morse MA, Hamblin PA | title = GRID: a novel Grb-2-related adapter protein that interacts with the activated T cell costimulatory receptor CD28 | journal = Journal of Immunology | volume = 164 | issue = 11 | pages = 5805–14 | date = Jun 2000 | pmid = 10820259 | doi =  10.4049/jimmunol.164.11.5805}}</ref>
* [[Linker of activated T cells]],<ref name = pmid10224278/><ref name = pmid10021361>{{cite journal | vauthors = Liu SK, Fang N, Koretzky GA, McGlade CJ | title = The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors | journal = Current Biology | volume = 9 | issue = 2 | pages = 67–75 | date = Jan 1999 | pmid = 10021361 | doi =  10.1016/s0960-9822(99)80017-7}}</ref>
* [[Lymphocyte cytosolic protein 2]]<ref name = pmid10224278/><ref name = pmid10820259/><ref name = pmid16189514/><ref name = pmid10021361/>
* [[MAP4K1]],<ref name = pmid11313918>{{cite journal | vauthors = Ma W, Xia C, Ling P, Qiu M, Luo Y, Tan TH, Liu M | title = Leukocyte-specific adaptor protein Grap2 interacts with hematopoietic progenitor kinase 1 (HPK1) to activate JNK signaling pathway in T lymphocytes | journal = Oncogene | volume = 20 | issue = 14 | pages = 1703–14 | date = Mar 2001 | pmid = 11313918 | doi = 10.1038/sj.onc.1204224 }}</ref> and
* [[STAMBP]].<ref name = pmid10224278 /><ref name = pmid16189514>{{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}</ref>
{{Div col end}}
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Bourette RP, Arnaud S, Myles GM, Blanchet JP, Rohrschneider LR, Mouchiroud G | title = Mona, a novel hematopoietic-specific adaptor interacting with the macrophage colony-stimulating factor receptor, is implicated in monocyte/macrophage development | journal = The EMBO Journal | volume = 17 | issue = 24 | pages = 7273–81 | date = Dec 1998 | pmid = 9857184 | pmc = 1171073 | doi = 10.1093/emboj/17.24.7273 }}
| citations =
* {{cite journal | vauthors = Liu SK, McGlade CJ | title = Gads is a novel SH2 and SH3 domain-containing adaptor protein that binds to tyrosine-phosphorylated Shc | journal = Oncogene | volume = 17 | issue = 24 | pages = 3073–82 | date = Dec 1998 | pmid = 9872323 | doi = 10.1038/sj.onc.1202337 }}
*{{cite journal | author=Bourette RP, Arnaud S, Myles GM, ''et al.'' |title=Mona, a novel hematopoietic-specific adaptor interacting with the macrophage colony-stimulating factor receptor, is implicated in monocyte/macrophage development. |journal=EMBO J. |volume=17 |issue= 24 |pages= 7273-81 |year= 1999 |pmid= 9857184 |doi= 10.1093/emboj/17.24.7273 }}
* {{cite journal | vauthors = Liu SK, Fang N, Koretzky GA, McGlade CJ | title = The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors | journal = Current Biology | volume = 9 | issue = 2 | pages = 67–75 | date = Jan 1999 | pmid = 10021361 | doi = 10.1016/S0960-9822(99)80017-7 }}
*{{cite journal | author=Liu SK, McGlade CJ |title=Gads is a novel SH2 and SH3 domain-containing adaptor protein that binds to tyrosine-phosphorylated Shc. |journal=Oncogene |volume=17 |issue= 24 |pages= 3073-82 |year= 1999 |pmid= 9872323 |doi= 10.1038/sj.onc.1202337 }}
* {{cite journal | vauthors = Law CL, Ewings MK, Chaudhary PM, Solow SA, Yun TJ, Marshall AJ, Hood L, Clark EA | title = GrpL, a Grb2-related adaptor protein, interacts with SLP-76 to regulate nuclear factor of activated T cell activation | journal = The Journal of Experimental Medicine | volume = 189 | issue = 8 | pages = 1243–53 | date = Apr 1999 | pmid = 10209041 | pmc = 2193019 | doi = 10.1084/jem.189.8.1243 }}
*{{cite journal | author=Qiu M, Hua S, Agrawal M, ''et al.'' |title=Molecular cloning and expression of human grap-2, a novel leukocyte-specific SH2- and SH3-containing adaptor-like protein that binds to gab-1. |journal=Biochem. Biophys. Res. Commun. |volume=253 |issue= 2 |pages= 443-7 |year= 1999 |pmid= 9878555 |doi= 10.1006/bbrc.1998.9795 }}
* {{cite journal | vauthors = Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP | title = The DNA sequence of human chromosome 22 | journal = Nature | volume = 402 | issue = 6761 | pages = 489–95 | date = Dec 1999 | pmid = 10591208 | doi = 10.1038/990031 }}
*{{cite journal | author=Liu SK, Fang N, Koretzky GA, McGlade CJ |title=The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors. |journal=Curr. Biol. |volume=9 |issue= 2 |pages= 67-75 |year= 1999 |pmid= 10021361 |doi= }}
* {{cite journal | vauthors = Xia C, Bao Z, Tabassam F, Ma W, Qiu M, Hua S, Liu M | title = GCIP, a novel human grap2 and cyclin D interacting protein, regulates E2F-mediated transcriptional activity | journal = The Journal of Biological Chemistry | volume = 275 | issue = 27 | pages = 20942–8 | date = Jul 2000 | pmid = 10801854 | doi = 10.1074/jbc.M002598200 }}
*{{cite journal | author=Law CL, Ewings MK, Chaudhary PM, ''et al.'' |title=GrpL, a Grb2-related adaptor protein, interacts with SLP-76 to regulate nuclear factor of activated T cell activation. |journal=J. Exp. Med. |volume=189 |issue= 8 |pages= 1243-53 |year= 1999 |pmid= 10209041 |doi= }}
* {{cite journal | vauthors = Zhang W, Trible RP, Zhu M, Liu SK, McGlade CJ, Samelson LE | title = Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling | journal = The Journal of Biological Chemistry | volume = 275 | issue = 30 | pages = 23355–61 | date = Jul 2000 | pmid = 10811803 | doi = 10.1074/jbc.M000404200 }}
*{{cite journal | author=Asada H, Ishii N, Sasaki Y, ''et al.'' |title=Grf40, A novel Grb2 family member, is involved in T cell signaling through interaction with SLP-76 and LAT. |journal=J. Exp. Med. |volume=189 |issue= 9 |pages= 1383-90 |year= 1999 |pmid= 10224278 |doi= }}
* {{cite journal | vauthors = Ellis JH, Ashman C, Burden MN, Kilpatrick KE, Morse MA, Hamblin PA | title = GRID: a novel Grb-2-related adapter protein that interacts with the activated T cell costimulatory receptor CD28 | journal = Journal of Immunology | volume = 164 | issue = 11 | pages = 5805–14 | date = Jun 2000 | pmid = 10820259 | doi = 10.4049/jimmunol.164.11.5805 }}
*{{cite journal | author=Dunham I, Shimizu N, Roe BA, ''et al.'' |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489-95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031 }}
* {{cite journal | vauthors = Ma W, Xia C, Ling P, Qiu M, Luo Y, Tan TH, Liu M | title = Leukocyte-specific adaptor protein Grap2 interacts with hematopoietic progenitor kinase 1 (HPK1) to activate JNK signaling pathway in T lymphocytes | journal = Oncogene | volume = 20 | issue = 14 | pages = 1703–14 | date = Mar 2001 | pmid = 11313918 | doi = 10.1038/sj.onc.1204224 }}
*{{cite journal | author=Xia C, Bao Z, Tabassam F, ''et al.'' |title=GCIP, a novel human grap2 and cyclin D interacting protein, regulates E2F-mediated transcriptional activity. |journal=J. Biol. Chem. |volume=275 |issue= 27 |pages= 20942-8 |year= 2000 |pmid= 10801854 |doi= 10.1074/jbc.M002598200 }}
* {{cite journal | vauthors = Poetsch A, Molday LL, Molday RS | title = The cGMP-gated channel and related glutamic acid-rich proteins interact with peripherin-2 at the rim region of rod photoreceptor disc membranes | journal = The Journal of Biological Chemistry | volume = 276 | issue = 51 | pages = 48009–16 | date = Dec 2001 | pmid = 11641407 | doi = 10.1074/jbc.M108941200 }}
*{{cite journal | author=Zhang W, Trible RP, Zhu M, ''et al.'' |title=Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling. |journal=J. Biol. Chem. |volume=275 |issue= 30 |pages= 23355-61 |year= 2000 |pmid= 10811803 |doi= 10.1074/jbc.M000404200 }}
* {{cite journal | vauthors = Wenzel J, Sanzenbacher R, Ghadimi M, Lewitzky M, Zhou Q, Kaplan DR, Kabelitz D, Feller SM, Janssen O | title = Multiple interactions of the cytosolic polyproline region of the CD95 ligand: hints for the reverse signal transduction capacity of a death factor | journal = FEBS Letters | volume = 509 | issue = 2 | pages = 255–62 | date = Dec 2001 | pmid = 11741599 | doi = 10.1016/S0014-5793(01)03174-X }}
*{{cite journal | author=Ellis JH, Ashman C, Burden MN, ''et al.'' |title=GRID: a novel Grb-2-related adapter protein that interacts with the activated T cell costimulatory receptor CD28. |journal=J. Immunol. |volume=164 |issue= 11 |pages= 5805-14 |year= 2000 |pmid= 10820259 |doi= }}
* {{cite journal | vauthors = Bourgin C, Bourette RP, Arnaud S, Liu Y, Rohrschneider LR, Mouchiroud G | title = Induced expression and association of the Mona/Gads adapter and Gab3 scaffolding protein during monocyte/macrophage differentiation | journal = Molecular and Cellular Biology | volume = 22 | issue = 11 | pages = 3744–56 | date = Jun 2002 | pmid = 11997510 | pmc = 133813 | doi = 10.1128/MCB.22.11.3744-3756.2002 }}
*{{cite journal | author=Ma W, Xia C, Ling P, ''et al.'' |title=Leukocyte-specific adaptor protein Grap2 interacts with hematopoietic progenitor kinase 1 (HPK1) to activate JNK signaling pathway in T lymphocytes. |journal=Oncogene |volume=20 |issue= 14 |pages= 1703-14 |year= 2001 |pmid= 11313918 |doi= 10.1038/sj.onc.1204224 }}
* {{cite journal | vauthors = Guyot B, Arnaud S, Phothirath P, Bourette RP, Grasset MF, Rigal D, Mouchiroud G | title = Genomic organization and restricted expression of the human Mona/Gads gene suggests regulation by two specific promoters | journal = Gene | volume = 290 | issue = 1-2 | pages = 173–9 | date = May 2002 | pmid = 12062812 | doi = 10.1016/S0378-1119(02)00555-3 }}
*{{cite journal | author=Poetsch A, Molday LL, Molday RS |title=The cGMP-gated channel and related glutamic acid-rich proteins interact with peripherin-2 at the rim region of rod photoreceptor disc membranes. |journal=J. Biol. Chem. |volume=276 |issue= 51 |pages= 48009-16 |year= 2002 |pmid= 11641407 |doi= 10.1074/jbc.M108941200 }}
* {{cite journal | vauthors = Lindholm CK, Henriksson ML, Hallberg B, Welsh M | title = Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells | journal = European Journal of Biochemistry / FEBS | volume = 269 | issue = 13 | pages = 3279–88 | date = Jul 2002 | pmid = 12084069 | doi = 10.1046/j.1432-1033.2002.03008.x }}
*{{cite journal | author=Wenzel J, Sanzenbacher R, Ghadimi M, ''et al.'' |title=Multiple interactions of the cytosolic polyproline region of the CD95 ligand: hints for the reverse signal transduction capacity of a death factor. |journal=FEBS Lett. |volume=509 |issue= 2 |pages= 255-62 |year= 2002 |pmid= 11741599 |doi= }}
* {{cite journal | vauthors = Zhu M, Janssen E, Leung K, Zhang W | title = Molecular cloning of a novel gene encoding a membrane-associated adaptor protein (LAX) in lymphocyte signaling | journal = The Journal of Biological Chemistry | volume = 277 | issue = 48 | pages = 46151–8 | date = Nov 2002 | pmid = 12359715 | doi = 10.1074/jbc.M208946200 }}
*{{cite journal | author=Bourgin C, Bourette RP, Arnaud S, ''et al.'' |title=Induced expression and association of the Mona/Gads adapter and Gab3 scaffolding protein during monocyte/macrophage differentiation. |journal=Mol. Cell. Biol. |volume=22 |issue= 11 |pages= 3744-56 |year= 2002 |pmid= 11997510 |doi= }}
* {{cite journal | vauthors = Guyot B, Arnaud S, Phothirath P, Rigal D, Mouchiroud G | title = Upstream open reading frames regulate translation of Mona/Gads adapter mRNA in the megakaryocytic lineage | journal = Platelets | volume = 13 | issue = 8 | pages = 459–64 | date = Dec 2002 | pmid = 12487779 | doi = 10.1080/0953710021000059431 }}
*{{cite journal | author=Guyot B, Arnaud S, Phothirath P, ''et al.'' |title=Genomic organization and restricted expression of the human Mona/Gads gene suggests regulation by two specific promoters. |journal=Gene |volume=290 |issue= 1-2 |pages= 173-9 |year= 2002 |pmid= 12062812 |doi= }}
* {{cite journal | vauthors = Yankee TM, Solow SA, Draves KD, Clark EA | title = Expression of the Grb2-related protein of the lymphoid system in B cell subsets enhances B cell antigen receptor signaling through mitogen-activated protein kinase pathways | journal = Journal of Immunology | volume = 170 | issue = 1 | pages = 349–55 | date = Jan 2003 | pmid = 12496419 | doi = 10.4049/jimmunol.170.1.349 }}
*{{cite journal | author=Lindholm CK, Henriksson ML, Hallberg B, Welsh M |title=Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells. |journal=Eur. J. Biochem. |volume=269 |issue= 13 |pages= 3279-88 |year= 2002 |pmid= 12084069 |doi= }}
*{{cite journal | author=Zhu M, Janssen E, Leung K, Zhang W |title=Molecular cloning of a novel gene encoding a membrane-associated adaptor protein (LAX) in lymphocyte signaling. |journal=J. Biol. Chem. |volume=277 |issue= 48 |pages= 46151-8 |year= 2003 |pmid= 12359715 |doi= 10.1074/jbc.M208946200 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Guyot B, Arnaud S, Phothirath P, ''et al.'' |title=Upstream open reading frames regulate translation of Mona/Gads adapter mRNA in the megakaryocytic lineage. |journal=Platelets |volume=13 |issue= 8 |pages= 459-64 |year= 2003 |pmid= 12487779 |doi= 10.1080/0953710021000059431 }}
*{{cite journal  | author=Yankee TM, Solow SA, Draves KD, Clark EA |title=Expression of the Grb2-related protein of the lymphoid system in B cell subsets enhances B cell antigen receptor signaling through mitogen-activated protein kinase pathways. |journal=J. Immunol. |volume=170 |issue= 1 |pages= 349-55 |year= 2003 |pmid= 12496419 |doi=  }}
}}
{{refend}}
{{refend}}


{{gene-22-stub}}
{{PDB Gallery|geneid=9402}}
{{WikiDoc Sources}}

Latest revision as of 09:04, 31 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

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RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

GRB2-related adapter protein 2 also known as GRB2-related adaptor downstream of Shc (GADS) is a 37 kDa protein that in humans is encoded by the GRAP2 gene.[1][2][3]

Function

This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Transcript variants utilizing alternative polyA sites exist.[3]

Interactions

GRAP2 has been shown to interact with:

References

  1. ↑ Qiu M, Hua S, Agrawal M, Li G, Cai J, Chan E, Zhou H, Luo Y, Liu M (Dec 1998). "Molecular cloning and expression of human grap-2, a novel leukocyte-specific SH2- and SH3-containing adaptor-like protein that binds to gab-1". Biochemical and Biophysical Research Communications. 253 (2): 443–7. doi:10.1006/bbrc.1998.9795. PMID 9878555.
  2. ↑ 2.0 2.1 2.2 2.3 Asada H, Ishii N, Sasaki Y, Endo K, Kasai H, Tanaka N, Takeshita T, Tsuchiya S, Konno T, Sugamura K (May 1999). "Grf40, A novel Grb2 family member, is involved in T cell signaling through interaction with SLP-76 and LAT". The Journal of Experimental Medicine. 189 (9): 1383–90. doi:10.1084/jem.189.9.1383. PMC 2193052. PMID 10224278.
  3. ↑ 3.0 3.1 "Entrez Gene: GRAP2 GRB2-related adaptor protein 2".
  4. ↑ Xia C, Bao Z, Tabassam F, Ma W, Qiu M, Hua S, Liu M (Jul 2000). "GCIP, a novel human grap2 and cyclin D interacting protein, regulates E2F-mediated transcriptional activity". The Journal of Biological Chemistry. 275 (27): 20942–8. doi:10.1074/jbc.M002598200. PMID 10801854.
  5. ↑ 5.0 5.1 Ellis JH, Ashman C, Burden MN, Kilpatrick KE, Morse MA, Hamblin PA (Jun 2000). "GRID: a novel Grb-2-related adapter protein that interacts with the activated T cell costimulatory receptor CD28". Journal of Immunology. 164 (11): 5805–14. doi:10.4049/jimmunol.164.11.5805. PMID 10820259.
  6. ↑ 6.0 6.1 Liu SK, Fang N, Koretzky GA, McGlade CJ (Jan 1999). "The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors". Current Biology. 9 (2): 67–75. doi:10.1016/s0960-9822(99)80017-7. PMID 10021361.
  7. ↑ 7.0 7.1 Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  8. ↑ Ma W, Xia C, Ling P, Qiu M, Luo Y, Tan TH, Liu M (Mar 2001). "Leukocyte-specific adaptor protein Grap2 interacts with hematopoietic progenitor kinase 1 (HPK1) to activate JNK signaling pathway in T lymphocytes". Oncogene. 20 (14): 1703–14. doi:10.1038/sj.onc.1204224. PMID 11313918.

Further reading

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