HSD17B7: Difference between revisions

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{{technical|date=June 2017}}
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'''3-keto-steroid reductase''' is an [[enzyme]] that in humans is encoded by the ''HSD17B7'' [[gene]].<ref name="pmid10544267">{{cite journal |vauthors=Krazeisen A, Breitling R, Imai K, Fritz S, Moller G, Adamski J | title = Determination of cDNA, gene structure and chromosomal localization of the novel human 17beta-hydroxysteroid dehydrogenase type 7(1) | journal = FEBS Lett | volume = 460 | issue = 2 | pages = 373–9 |date=Dec 1999 | pmid = 10544267 | pmc =  | doi =10.1016/S0014-5793(99)01366-6  }}</ref><ref name="pmid10419022">{{cite journal |vauthors=Peltoketo H, Nokelainen P, Piao YS, Vihko R, Vihko P | title = Two 17beta-hydroxysteroid dehydrogenases (17HSDs) of estradiol biosynthesis: 17HSD type 1 and type 7 | journal = J Steroid Biochem Mol Biol | volume = 69 | issue = 1–6 | pages = 431–9 |date=Aug 1999 | pmid = 10419022 | pmc = | doi =10.1016/S0960-0760(99)00064-3  }}</ref><ref name="pmid19027726">{{cite journal |vauthors=Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U | title = The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative | journal = Chem Biol Interact | volume = 178 | issue = 1–3 | pages = 94–8 |date=Feb 2009 | pmid = 19027726 | pmc =  2896744| doi = 10.1016/j.cbi.2008.10.040 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51478| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Hydroxysteroid (17-beta) dehydrogenase 7
| HGNCid = 5215
| Symbol = HSD17B7
| AltSymbols =; PRAP; MGC12523; MGC75018
| OMIM = 606756
| ECnumber =
| Homologene = 40728
| MGIid = 1330808
  | Function = {{GNF_GO|id=GO:0004303 |text = estradiol 17-beta-dehydrogenase activity}} {{GNF_GO|id=GO:0016491 |text = oxidoreductase activity}} {{GNF_GO|id=GO:0050576 |text = 3-keto-steroid reductase activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006694 |text = steroid biosynthetic process}} {{GNF_GO|id=GO:0008152 |text = metabolic process}}  
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 51478
    | Hs_Ensembl =
    | Hs_RefseqProtein = NP_057455
    | Hs_RefseqmRNA = NM_016371
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr =
    | Hs_GenLoc_start =
    | Hs_GenLoc_end =
    | Hs_Uniprot =   
    | Mm_EntrezGene = 15490
    | Mm_Ensembl = ENSMUSG00000026675
    | Mm_RefseqmRNA = NM_010476
    | Mm_RefseqProtein = NP_034606
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 171786212
    | Mm_GenLoc_end = 171805880
    | Mm_Uniprot = O88736
  }}
}}
'''Hydroxysteroid (17-beta) dehydrogenase 7''', also known as '''HSD17B7''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51478| accessdate = }}</ref>


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| section_title =  
| section_title =  
| summary_text = The 17-beta-hydroxysteroid dehydrogenase enzyme (EC 1.1.1.62) oxidizes or reduces estrogens and androgens in mammals and regulates the biologic potency of these steroids.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51478| accessdate = }}</ref>
| summary_text = The 17-beta-hydroxysteroid dehydrogenase enzyme (EC 1.1.1.62) oxidizes or reduces estrogens and androgens in mammals and regulates the biologic potency of these steroids.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51478| accessdate = }}</ref>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Peltoketo H, Nokelainen P, Piao YS, ''et al.'' |title=Two 17beta-hydroxysteroid dehydrogenases (17HSDs) of estradiol biosynthesis: 17HSD type 1 and type 7. |journal=J. Steroid Biochem. Mol. Biol. |volume=69 |issue= 1-6 |pages= 431-9 |year= 1999 |pmid= 10419022 |doi=  }}
*{{cite journal  |vauthors=Mendoza-Hernández G, Rendón JL, Díaz-Zagoya JC |title=A single step procedure for purification of estradiol 17 beta-dehydrogenase from human placenta. |journal=Biochem. Biophys. Res. Commun. |volume=126 |issue= 1 |pages= 477–81 |year= 1985 |pmid= 3855619 |doi=10.1016/0006-291X(85)90630-8 }}
*{{cite journal  | author=Mendoza-Hernández G, Rendón JL, Díaz-Zagoya JC |title=A single step procedure for purification of estradiol 17 beta-dehydrogenase from human placenta. |journal=Biochem. Biophys. Res. Commun. |volume=126 |issue= 1 |pages= 477-81 |year= 1985 |pmid= 3855619 |doi= }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Krazeisen A, Breitling R, Imai K, ''et al.'' |title=Determination of cDNA, gene structure and chromosomal localization of the novel human 17beta-hydroxysteroid dehydrogenase type 7(1). |journal=FEBS Lett. |volume=460 |issue= 2 |pages= 373-9 |year= 1999 |pmid= 10544267 |doi= }}
*{{cite journal   |vauthors=Törn S, Nokelainen P, Kurkela R, etal |title=Production, purification, and functional analysis of recombinant human and mouse 17beta-hydroxysteroid dehydrogenase type 7. |journal=Biochem. Biophys. Res. Commun. |volume=305 |issue= 1 |pages= 37–45 |year= 2003 |pmid= 12732193 |doi=10.1016/S0006-291X(03)00694-6 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Marijanovic Z, Laubner D, Moller G, etal |title=Closing the gap: identification of human 3-ketosteroid reductase, the last unknown enzyme of mammalian cholesterol biosynthesis. |journal=Mol. Endocrinol. |volume=17 |issue= 9 |pages= 1715–25 |year= 2004 |pmid= 12829805 |doi= 10.1210/me.2002-0436 }}
*{{cite journal | author=Törn S, Nokelainen P, Kurkela R, ''et al.'' |title=Production, purification, and functional analysis of recombinant human and mouse 17beta-hydroxysteroid dehydrogenase type 7. |journal=Biochem. Biophys. Res. Commun. |volume=305 |issue= 1 |pages= 37-45 |year= 2003 |pmid= 12732193 |doi=  }}
*{{cite journal   |vauthors=Clark HF, Gurney AL, Abaya E, etal |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 | pmc=403697 }}
*{{cite journal | author=Marijanovic Z, Laubner D, Moller G, ''et al.'' |title=Closing the gap: identification of human 3-ketosteroid reductase, the last unknown enzyme of mammalian cholesterol biosynthesis. |journal=Mol. Endocrinol. |volume=17 |issue= 9 |pages= 1715-25 |year= 2004 |pmid= 12829805 |doi= 10.1210/me.2002-0436 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Clark HF, Gurney AL, Abaya E, ''et al.'' |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265-70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  |vauthors=Ohnesorg T, Adamski J |title=Promoter analyses of human and mouse 17beta-hydroxysteroid dehydrogenase type 7. |journal=J. Steroid Biochem. Mol. Biol. |volume=94 |issue= 1-3 |pages= 259–61 |year= 2005 |pmid= 15862973 |doi= 10.1016/j.jsbmb.2005.01.012 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  |vauthors=Ohnesorg T, Adamski J |title=Analysis of the 5' flanking regions of human and murine HSD17B7: identification of a cholesterol dependent enhancer region. |journal=Mol. Cell. Endocrinol. |volume=248 |issue= 1-2 |pages= 164–7 |year= 2006 |pmid= 16356630 |doi= 10.1016/j.mce.2005.10.016 }}
*{{cite journal  | author=Ohnesorg T, Adamski J |title=Promoter analyses of human and mouse 17beta-hydroxysteroid dehydrogenase type 7. |journal=J. Steroid Biochem. Mol. Biol. |volume=94 |issue= 1-3 |pages= 259-61 |year= 2005 |pmid= 15862973 |doi= 10.1016/j.jsbmb.2005.01.012 }}
*{{cite journal  |vauthors=Ohnesorg T, Keller B, Hrabé de Angelis M, Adamski J |title=Transcriptional regulation of human and murine 17beta-hydroxysteroid dehydrogenase type-7 confers its participation in cholesterol biosynthesis. |journal=J. Mol. Endocrinol. |volume=37 |issue= 1 |pages= 185–97 |year= 2007 |pmid= 16901934 |doi= 10.1677/jme.1.02043 }}
*{{cite journal  | author=Ohnesorg T, Adamski J |title=Analysis of the 5' flanking regions of human and murine HSD17B7: identification of a cholesterol dependent enhancer region. |journal=Mol. Cell. Endocrinol. |volume=248 |issue= 1-2 |pages= 164-7 |year= 2006 |pmid= 16356630 |doi= 10.1016/j.mce.2005.10.016 }}
*{{cite journal   |vauthors=Smuc T, Pucelj MR, Sinkovec J, etal |title=Expression analysis of the genes involved in estradiol and progesterone action in human ovarian endometriosis. |journal=Gynecol. Endocrinol. |volume=23 |issue= 2 |pages= 105–11 |year= 2007 |pmid= 17454161 |doi= 10.1080/09513590601152219 }}
*{{cite journal  | author=Ohnesorg T, Keller B, Hrabé de Angelis M, Adamski J |title=Transcriptional regulation of human and murine 17beta-hydroxysteroid dehydrogenase type-7 confers its participation in cholesterol biosynthesis. |journal=J. Mol. Endocrinol. |volume=37 |issue= 1 |pages= 185-97 |year= 2007 |pmid= 16901934 |doi= 10.1677/jme.1.02043 }}
*{{cite journal  |vauthors=Guggenberger C, Ilgen D, Adamski J |title=Functional analysis of cholesterol biosynthesis by RNA interference. |journal=J. Steroid Biochem. Mol. Biol. |volume=104 |issue= 3-5 |pages= 105–9 |year= 2007 |pmid= 17498944 |doi= 10.1016/j.jsbmb.2007.03.001 }}
*{{cite journal | author=Smuc T, Pucelj MR, Sinkovec J, ''et al.'' |title=Expression analysis of the genes involved in estradiol and progesterone action in human ovarian endometriosis. |journal=Gynecol. Endocrinol. |volume=23 |issue= 2 |pages= 105-11 |year= 2007 |pmid= 17454161 |doi= 10.1080/09513590601152219 }}
*{{cite journal  | author=Guggenberger C, Ilgen D, Adamski J |title=Functional analysis of cholesterol biosynthesis by RNA interference. |journal=J. Steroid Biochem. Mol. Biol. |volume=104 |issue= 3-5 |pages= 105-9 |year= 2007 |pmid= 17498944 |doi= 10.1016/j.jsbmb.2007.03.001 }}
}}
}}
{{refend}}
{{refend}}
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Latest revision as of 14:07, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

3-keto-steroid reductase is an enzyme that in humans is encoded by the HSD17B7 gene.[1][2][3][4]

The 17-beta-hydroxysteroid dehydrogenase enzyme (EC 1.1.1.62) oxidizes or reduces estrogens and androgens in mammals and regulates the biologic potency of these steroids.[supplied by OMIM][4]

References

  1. ↑ Krazeisen A, Breitling R, Imai K, Fritz S, Moller G, Adamski J (Dec 1999). "Determination of cDNA, gene structure and chromosomal localization of the novel human 17beta-hydroxysteroid dehydrogenase type 7(1)". FEBS Lett. 460 (2): 373–9. doi:10.1016/S0014-5793(99)01366-6. PMID 10544267.
  2. ↑ Peltoketo H, Nokelainen P, Piao YS, Vihko R, Vihko P (Aug 1999). "Two 17beta-hydroxysteroid dehydrogenases (17HSDs) of estradiol biosynthesis: 17HSD type 1 and type 7". J Steroid Biochem Mol Biol. 69 (1–6): 431–9. doi:10.1016/S0960-0760(99)00064-3. PMID 10419022.
  3. ↑ Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chem Biol Interact. 178 (1–3): 94–8. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.
  4. ↑ 4.0 4.1 "Entrez Gene: HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7".

Further reading



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