Multiple endocrine neoplasia type 1 epidemiology and demographics: Difference between revisions

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{{Multiple endocrine neoplasia type 1}}
{{CMG}}; {{AE}} {{Ammu}}
{{CMG}}; {{AE}} {{Ammu}}
==Overview==
==Overview==
The [[prevalence]] of [[multiple endocrine neoplasia]] type-1 ([[MEN, type 1|MEN]]-1) is approximately 2-3 per 100,000 individuals worldwide. Patients of all age groups may develop [[Multiple endocrine neoplasia type 1|MEN-1]], but it is commonly [[Diagnose|diagnosed]] among patients between 18-50 years of age. [[Multiple endocrine neoplasia type 1|MEN-1]] affects men and women equally. There is no racial predilection to [[Multiple endocrine neoplasia type 1|MEN-1]].
==Epidemiology and Demographics==
==Epidemiology and Demographics==
==Prevalence==
===Prevalence===
**Worldwide, the [[prevalence]] of (insert disease state here) ranges from a low of _____ per 100,000 persons  to a high of _____ per 100,000 persons with an average prevalence of _____ per 100,000 persons.
* Worldwide, the [[prevalence]] of [[Multiple endocrine neoplasia type 1|MEN-1]] is estimated to be 2-3 per 100,000.<ref>[http://www.hindawi.com/journals/jo/2012/705036/cta/] C. Romei, E. Pardi, F. Cetani, and R. Elisei, “Genetic and Clinical Features of Multiple Endocrine Neoplasia Types 1 and 2,” Journal of Oncology, vol. 2012, Article ID 705036, 15 pages, 2012. doi:10.1155/2012/705036</ref>
**In developed countries, the [[prevalence]] of (insert disease state here) ranges from a low of _____ per 100,000 persons  to a high of _____ per 100,000 persons with an average prevalence of _____ per 100,000 persons.
**In developed countries, the [[prevalence]] of (insert disease state here) is _____ per 100,000 persons.
==Incidence==
**Worldwide, the [[incidence]] of (insert disease state here) ranges from a low of _____ per 100,000 persons  to a high of _____ per 100,000 persons with an average incidence of _____ per 100,000 persons.
**In developed countries, the [[incidence]] of (insert disease state here) is _____ per 100,000 persons.
**In developing countries/ Africa, the [[incidence]] of (insert disease state here) ranges from a low of _____ per 100,000 persons  to a high of _____ per 100,000 persons with an average incidence of _____ per 100,000 persons.
==Age==
* Endocrine and non-[[endocrine]] manifestations of the [[disease]] in MEN1 patients most often begin in the fourth or fifth decade. The onset of the [[disease]] is rare before age 10 years.
 
==Gender==
* The prevalence and incidence of (insert disease state here) does not vary by gender.
* Men and women are affected equally by (insert disease name here).
* (Insert disease state here) is more prevalent in men  women.
* The [[prevalence]] of (insert disease state here) among men is ____ per 100,000, while it is _____ per 100,000 among women.
* The [[incidence]] of (insert disease state here) among men is ____ per 100,000, while it is _____ per 100,000 among women.
 
==Race==


* The prevalence of (insert disease state here) does not vary by race.
===Age===
* (Insert disease state here) is more prevalent in the ____race and ____ races.
* [[Endocrine]] and non-[[endocrine]] manifestations of the [[disease]] in [[Multiple endocrine neoplasia type 1|MEN-1]] patients most often begin in the fourth or fifth decade.
* The onset of the [[disease]] is rare before 10 years of age.<ref name="pmiddoi:10.1016/j.beem.2010.07.003">{{cite journal| author=Schmoldt A, Benthe HF, Haberland G| title=Digitoxin metabolism by rat liver microsomes. | journal=Biochem Pharmacol | year= 1975 | volume= 24 | issue= 17 | pages= 1639-41 | pmid=doi:10.1016/j.beem.2010.07.003 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10  }} </ref><ref name="pmid17014705">{{cite journal| author=Marini F, Falchetti A, Del Monte F, Carbonell Sala S, Gozzini A, Luzi E et al.| title=Multiple endocrine neoplasia type 1. | journal=Orphanet J Rare Dis | year= 2006 | volume= 1 | issue=  | pages= 38 | pmid=17014705 | doi=10.1186/1750-1172-1-38 | pmc=PMC1594566 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17014705  }} </ref>


==Developed Countries==
===Gender===
* In this section you should describe the impact of the disease in developed countries.
* Men and women are affected equally by [[Multiple endocrine neoplasia type 1|MEN-1]].<ref name="pmiddoi:10.1016/j.beem.2010.07.003">{{cite journal| author=Schmoldt A, Benthe HF, Haberland G| title=Digitoxin metabolism by rat liver microsomes. | journal=Biochem Pharmacol | year= 1975 | volume= 24 | issue= 17 | pages= 1639-41 | pmid=doi:10.1016/j.beem.2010.07.003 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10  }} </ref><ref name="pmid21551167">{{cite journal| author=Goudet P, Bonithon-Kopp C, Murat A, Ruszniewski P, Niccoli P, Ménégaux F et al.| title=Gender-related differences in MEN1 lesion occurrence and diagnosis: a cohort study of 734 cases from the Groupe d'etude des Tumeurs Endocrines. | journal=Eur J Endocrinol | year= 2011 | volume= 165 | issue= 1 | pages= 97-105 | pmid=21551167 | doi=10.1530/EJE-10-0950 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21551167  }} </ref>
* Incidence, prevalence, and geographical distribution or areas of interest can be mentioned, as well as the impact the disease has on society.
* Men have a higher [[incidence]] of [[pancreatic tumor]]s, whereas women have a higher [[incidence]] of [[pituitary tumor]]s.
* For an example of a developed countries section in an epidemiology and demographics page, click [[Chronic stable angina epidemiology#Developed countries|here]].
* Thymic [[tumor]]s are common among men.


==Developing Countries==
===Race===
* In this section you should describe the impact of the disease in developing countries.
* There is no racial predilection to [[Multiple endocrine neoplasia type 1|MEN-1]].
* Incidence, prevalence, and geographical distribution or areas of interest can be mentioned, as well as the impact the disease has on society.
* For an example of a developing countries section in an epidemiology and demographics page, click [[Chronic stable angina epidemiology#Developing Countries|here]].


==References==
==References==
{{Reflist|2}}
{{reflist|2}}


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Latest revision as of 02:45, 27 November 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [2]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [3]

Overview

The prevalence of multiple endocrine neoplasia type-1 (MEN-1) is approximately 2-3 per 100,000 individuals worldwide. Patients of all age groups may develop MEN-1, but it is commonly diagnosed among patients between 18-50 years of age. MEN-1 affects men and women equally. There is no racial predilection to MEN-1.

Epidemiology and Demographics

Prevalence

Age

Gender

Race

  • There is no racial predilection to MEN-1.

References

  1. ↑ [1] C. Romei, E. Pardi, F. Cetani, and R. Elisei, “Genetic and Clinical Features of Multiple Endocrine Neoplasia Types 1 and 2,” Journal of Oncology, vol. 2012, Article ID 705036, 15 pages, 2012. doi:10.1155/2012/705036
  2. ↑ 2.0 2.1 Schmoldt A, Benthe HF, Haberland G (1975). "Digitoxin metabolism by rat liver microsomes". Biochem Pharmacol. 24 (17): 1639–41. PMID doi:10.1016/j.beem.2010.07.003 Check |pmid= value (help).
  3. ↑ Marini F, Falchetti A, Del Monte F, Carbonell Sala S, Gozzini A, Luzi E; et al. (2006). "Multiple endocrine neoplasia type 1". Orphanet J Rare Dis. 1: 38. doi:10.1186/1750-1172-1-38. PMC 1594566. PMID 17014705.
  4. ↑ Goudet P, Bonithon-Kopp C, Murat A, Ruszniewski P, Niccoli P, Ménégaux F; et al. (2011). "Gender-related differences in MEN1 lesion occurrence and diagnosis: a cohort study of 734 cases from the Groupe d'etude des Tumeurs Endocrines". Eur J Endocrinol. 165 (1): 97–105. doi:10.1530/EJE-10-0950. PMID 21551167.

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