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{{Systemic lupus erythematosus}}
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==Overview==
==Overview==


==Prognosis==
==Natural History==
 
In the 1950s, most people diagnosed with SLE lived fewer than five years. Advances in diagnosis and treatment have improved survival to the point where over 90% now survive for more than ten years, and many can live relatively asymptomatically. Prognosis is normally worse for men and children than for women; however, if symptoms are present after age 60, the disease tends to run a more benign course. Early mortality, within 5 years, is due to organ failure or overwhelming infections, both of which can be modified by early diagnosis and treatment. The mortality risk is five-fold when compared to the normal population in the late stages, which can be attributed to cardiovascular diseases acquired from corticosteroid therapy. To reduce potential for cardiovascular issues, steroids should be used at the lowest dose for the shortest possible period. High serum creatinine, hypertension, [[nephrotic syndrome]], anemia and hypoalbuminemia are poor prognostic factors.<ref name="prognosis">[http://medicalpresentations.lifehugger.com/doc/sle-systemic-lupus-erythematosus Poor prognostic factors,Sudheer, SLE document]</ref>


The ANA is the most sensitive screening test for evaluation, whereas [[LSm#History|anti-Sm (anti-Smith)]] is the most specific. The dsDNA (double-stranded [[DNA]]) antibody is also fairly specific and often fluctuates with disease activity; as such, the dsDNA titer is sometimes useful to monitor disease flares or response to treatment.<ref>[Early steroids may prevent relapses in lupus, P Jarman (Published in Journal Watch (General) July 18, 1995)</ref>
==Complications==
Some people with SLE have abnormal deposits in the kidney cells. This leads to a condition called [[lupus nephritis]]. Patients with this condition may eventually develop kidney failure and need [[dialysis]] or a kidney transplant.


==Lupus and Quality of Life==
SLE causes damage to many different parts of the body, including:


Despite the symptoms of lupus and the potential side-effects of treatment, people with lupus can maintain a high quality of life overall. One key to managing lupus is to understand the disease and its impact. Learning to recognize the warning signs of a flare can help the patient take steps to ward it off or reduce its intensity. Many people with lupus experience increased fatigue, pain, a rash, fever, abdominal discomfort, headache, or dizziness just before a flare. Developing strategies to prevent flares can also be helpful, such as learning to recognize your warning signals and maintaining good communication with your doctor.
* Blood clots in the legs ([[deep vein thrombosis]]) or lungs ([[pulmonary embolism]])
* Destruction of red blood cells ([[hemolytic anemia]]) or [[anemia of chronic disease]]
* Fluid around the heart ([[pericarditis]]), [[endocarditis]], or inflammation of the heart ([[myocarditis]])
* Fluid around the lungs ([[pleural effusions]]) and damage to lung tissue
* Pregnancy complications, including [[miscarriage]]
* [[Stroke]]
* Severely [[low blood platelets]] ([[thrombocytopenia]])
* [[Inflammation]] of the blood vessels


It is also important for people with lupus to receive regular health care, instead of seeking help only when symptoms worsen. Results from a medical exam and laboratory work on a regular basis allows the doctor to note any changes and to identify and treat flares early. The treatment plan, which is tailored to the individual's specific needs and circumstances, can be adjusted accordingly. If new symptoms are identified early, treatments may be more effective. Other concerns also can be addressed at regular checkups. The doctor can provide guidance about such issues as the use of sunscreens, stress reduction, and the importance of structured exercise and rest, as well as birth control and family planning. Because people with lupus can be more susceptible to infections, the doctor may recommend yearly influenza vaccinations or pneumococcal vaccinations for some patients.
==Prognosis==
 
In the 1950s, most people diagnosed with SLE lived fewer than five years. Advances in diagnosis and treatment have improved survival to the point where over 90% now survive for more than ten years, and many can live relatively asymptomatically. Prognosis is normally worse for men and children than for women; however, if symptoms are present after age 60, the disease tends to run a more benign course. Early mortality, within 5 years, is due to organ failure or overwhelming infections, both of which can be modified by early diagnosis and treatment. The mortality risk is five-fold when compared to the normal population in the late stages, which can be attributed to cardiovascular diseases acquired from corticosteroid therapy. To reduce potential for cardiovascular issues, steroids should be used at the lowest dose for the shortest possible period. High serum [[creatinine]], [[hypertension]], [[nephrotic syndrome]], [[anemia]] and [[hypoalbuminemia]] are poor prognostic factors.<ref name="prognosis">[http://medicalpresentations.lifehugger.com/doc/sle-systemic-lupus-erythematosus Poor prognostic factors,Sudheer, SLE document]</ref>
Women with lupus should receive regular preventive health care, such as gynecological and breast examinations. Men with lupus should have the prostate-specific antigen (PSA) test. Both men and women need to have their blood pressure and cholesterol checked on a regular basis. If a person is taking corticosteroids or antimalarial medications, an eye exam should be done at least yearly to screen for and treat eye problems.
 
Staying healthy requires extra effort and care for people with lupus, so it becomes especially important to develop strategies for maintaining wellness. Wellness involves close attention to the body, mind, and spirit. One of the primary goals of wellness for people with lupus is coping with the stress of having a chronic disorder. Effective stress management varies from person to person. Some approaches that may help include exercise, relaxation techniques such as meditation, and setting priorities for spending time and energy.
 
Developing and maintaining a good support system is also important. A support system may include family, friends, medical professionals, community organizations, and support groups. Participating in a support group can provide emotional help, boost self-esteem and morale, and help develop or improve coping skills.


The ANA is the most sensitive screening test for evaluation, whereas [[LSm#History|anti-Sm (anti-Smith)]] is the most specific. The dsDNA (double-stranded [[DNA]]) antibody is also fairly specific and often fluctuates with disease activity; as such, the dsDNA titer is sometimes useful to monitor disease flares or response to treatment.<ref>[Early steroids may prevent relapses in lupus, P Jarman (Published in Journal Watch (General) July 18, 1995)</ref>


==References==
==References==
{{reflist|2}}
{{reflist|2}}


 
[[Category:Arthritis]]
 
[[Category:Dermatology]]
[[Category:Diseases involving the fasciae]]
[[Category:Rheumatology]]
[[Category:Nephrology]]
[[Category:Autoimmune diseases]]
[[Category:Disease]]
[[Category:Needs content]]
{{WH}}
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Latest revision as of 17:31, 19 July 2017

Systemic lupus erythematosus Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Systemic lupus erythematosus from other Diseases

Epidemiology and Demographics

Risk Factors

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Natural History, Complications and Prognosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2]

Overview

Natural History

Complications

Some people with SLE have abnormal deposits in the kidney cells. This leads to a condition called lupus nephritis. Patients with this condition may eventually develop kidney failure and need dialysis or a kidney transplant.

SLE causes damage to many different parts of the body, including:

Prognosis

In the 1950s, most people diagnosed with SLE lived fewer than five years. Advances in diagnosis and treatment have improved survival to the point where over 90% now survive for more than ten years, and many can live relatively asymptomatically. Prognosis is normally worse for men and children than for women; however, if symptoms are present after age 60, the disease tends to run a more benign course. Early mortality, within 5 years, is due to organ failure or overwhelming infections, both of which can be modified by early diagnosis and treatment. The mortality risk is five-fold when compared to the normal population in the late stages, which can be attributed to cardiovascular diseases acquired from corticosteroid therapy. To reduce potential for cardiovascular issues, steroids should be used at the lowest dose for the shortest possible period. High serum creatinine, hypertension, nephrotic syndrome, anemia and hypoalbuminemia are poor prognostic factors.[1]

The ANA is the most sensitive screening test for evaluation, whereas anti-Sm (anti-Smith) is the most specific. The dsDNA (double-stranded DNA) antibody is also fairly specific and often fluctuates with disease activity; as such, the dsDNA titer is sometimes useful to monitor disease flares or response to treatment.[2]

References

  1. ↑ Poor prognostic factors,Sudheer, SLE document
  2. ↑ [Early steroids may prevent relapses in lupus, P Jarman (Published in Journal Watch (General) July 18, 1995)

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