Spinal cord compression pathophysiology: Difference between revisions

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{{CMG}} ; {{AE}} {{ADG}}
{{CMG}} ; {{AE}} {{ADG}}
==Overview==
==Overview==
The [[spinal cord]] extends from the [[foramen magnum]] down to the level of the first and second [[lumbar vertebrae]]. The [[Spinal cord|cord]] is protected by the [[vertebral column]], which is mobile and allows for movement of the spine. It is enclosed by the [[dura mater]] and the vessels supplying it. The [[spinal cord]] and [[nerve root]]<nowiki/>s depend on a constant blood supply to perform axonal signaling. Conditions that interfere, either directly or indirectly with the blood supply will cause malfunction of the transmission pathway. Injury to the [[spinal cord]] or nerve roots arises from direct [[trauma]], [[Compression fracture|compression by bone fragments]], [[hematoma]], or disk herniation or [[ischemia]]. The tissue responses by [[gliosis]], [[demyelination]], and [[axonal]] loss. This results in injury to the [[White matter|white matte]]<nowiki/>r (myelinated tracts) and the [[Grey matter|gray matter]] (cell bodies) in the [[Spinal cord|cord]] with loss of [[Reflexes|sensory reflexes]] (pinprick, joint position sense, [[vibration]], hot/cold, pressure) and [[Motor control|motor function]].<ref name="pmid23186894">{{cite journal |vauthors=Bican O, Minagar A, Pruitt AA |title=The spinal cord: a review of functional neuroanatomy |journal=Neurol Clin |volume=31 |issue=1 |pages=1–18 |year=2013 |pmid=23186894 |doi=10.1016/j.ncl.2012.09.009 |url=}}</ref><ref name="pmid27616310">{{cite journal |vauthors=Diaz E, Morales H |title=Spinal Cord Anatomy and Clinical Syndromes |journal=Semin. Ultrasound CT MR |volume=37 |issue=5 |pages=360–71 |year=2016 |pmid=27616310 |doi=10.1053/j.sult.2016.05.002 |url=}}</ref>
==Pathophysiology==
==Pathophysiology==
===Anotomy===
===Anatomy===
*The spinal cord extends from the foramen magnum down to the level of the first and second lumbar vertebrae.<ref name="pmid23186894">{{cite journal |vauthors=Bican O, Minagar A, Pruitt AA |title=The spinal cord: a review of functional neuroanatomy |journal=Neurol Clin |volume=31 |issue=1 |pages=1–18 |year=2013 |pmid=23186894 |doi=10.1016/j.ncl.2012.09.009 |url=}}</ref><ref name="pmid27616310">{{cite journal |vauthors=Diaz E, Morales H |title=Spinal Cord Anatomy and Clinical Syndromes |journal=Semin. Ultrasound CT MR |volume=37 |issue=5 |pages=360–71 |year=2016 |pmid=27616310 |doi=10.1053/j.sult.2016.05.002 |url=}}</ref>
*The [[spinal cord]] extends from the [[foramen magnum]] down to the level of the first and second [[lumbar vertebrae]].<ref name="pmid23186894">{{cite journal |vauthors=Bican O, Minagar A, Pruitt AA |title=The spinal cord: a review of functional neuroanatomy |journal=Neurol Clin |volume=31 |issue=1 |pages=1–18 |year=2013 |pmid=23186894 |doi=10.1016/j.ncl.2012.09.009 |url=}}</ref><ref name="pmid27616310">{{cite journal |vauthors=Diaz E, Morales H |title=Spinal Cord Anatomy and Clinical Syndromes |journal=Semin. Ultrasound CT MR |volume=37 |issue=5 |pages=360–71 |year=2016 |pmid=27616310 |doi=10.1053/j.sult.2016.05.002 |url=}}</ref>
*At L2 level spinal cord transforms into spinal roots and forms a cone-shaped structure called conus medullaris.  
*At L2 level [[spinal cord]] transforms into spinal roots and forms a cone-shaped structure called [[Conus medullaris|conus medullaris.]]
*The cord is protected by the vertebral column, which is mobile and allows for movement of the spine.  
*The cord is protected by the [[vertebral column]], which is mobile and allows for movement of the spine.  
*It is enclosed by the dura mater and the vessels supplying it.
*It is enclosed by the [[dura mater]] and the vessels supplying it.
*The cord floats in the cerebrospinal fluid which acts as a buffer to movement and early degrees of compression.  
*The cord floats in the [[cerebrospinal fluid]] which acts as a buffer to movement and early degrees of compression.  
*The cord substance contains a gray area centrally and is surrounded by white matter communication tracts, both ascending and descending.
*The cord substance contains a [[Grey matter|gray area]] centrally and is surrounded by [[white matter]] communication tracts, both ascending and descending.
[[Image:Diagram_of_the_spinal_cord_CRUK_046.svg.png|center|500px|]]
 
===Pathogenesis===
*The [[spinal cord]] and [[Nerve root|nerve roots]] depend on a constant blood supply to perform axonal signaling.<ref name="pmid24406153">{{cite journal |vauthors=Pekny M, Wilhelmsson U, Pekna M |title=The dual role of astrocyte activation and reactive gliosis |journal=Neurosci. Lett. |volume=565 |issue= |pages=30–8 |year=2014 |pmid=24406153 |doi=10.1016/j.neulet.2013.12.071 |url=}}</ref><ref name="pmid23250681">{{cite journal |vauthors=Vilar-González S, Pérez-Rozos A, Torres-Campa JM, Mateos V |title=[Spinal cord compression: a multidisciplinary approach to a real neuro-oncological emergency] |language=Spanish; Castilian |journal=Rev Neurol |volume=56 |issue=1 |pages=43–52 |year=2013 |pmid=23250681 |doi= |url=}}</ref><ref name="pmid16194459">{{cite journal |vauthors=Schmidt MH, Klimo P, Vrionis FD |title=Metastatic spinal cord compression |journal=J Natl Compr Canc Netw |volume=3 |issue=5 |pages=711–9 |year=2005 |pmid=16194459 |doi= |url=}}</ref>
*Conditions that interfere, either directly or indirectly, with the blood supply will cause malfunction of the transmission pathway.
*Injury to the spinal cord or nerve roots arises from direct [[Trauma|trauma,]] [[Compression fracture|compression by bone fragments]], [[hematoma]], or disc herniation or [[ischemia]].
*It initiates a cascade of events in the [[Grey matter|gray matte]]<nowiki/>r and [[white matter]] and results in [[hypoperfusion]].
*The following results in [[autonomic dysfunction]] leading to [[neurogenic shock]] ( triad of [[hypotension]], [[bradycardia]] and peripheral vasodilation) and eventually [[Necrosis|hemorrhagic necrosis.]]
*The extent of [[necrosis]] depends on the severity of the [[trauma]], concomitant compression, and blood flow.
*The tissue responses by [[gliosis]], [[demyelination]], and axonal loss.
*This results in injury to the [[White matter|white matte]]<nowiki/>r (myelinated tracts) and the [[Grey matter|gray matter]] (cell bodies) in the cord with loss of [[Reflexes|sensory reflexes]] (pinprick, joint position sense, vibration, hot/cold, pressure) and [[Motor Control|motor function]].
*Rapid compression will result in the collapse of the [[Venous blood|venous system]], resulting in [[vasogenic edema]].
*[[Vasogenic edema]] exacerbates parenchymal pressure and may lead to rapid progression of dysfunction.


== References ==
== References ==

Latest revision as of 17:37, 18 April 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Aditya Ganti M.B.B.S. [2]

Overview

The spinal cord extends from the foramen magnum down to the level of the first and second lumbar vertebrae. The cord is protected by the vertebral column, which is mobile and allows for movement of the spine. It is enclosed by the dura mater and the vessels supplying it. The spinal cord and nerve roots depend on a constant blood supply to perform axonal signaling. Conditions that interfere, either directly or indirectly with the blood supply will cause malfunction of the transmission pathway. Injury to the spinal cord or nerve roots arises from direct trauma, compression by bone fragments, hematoma, or disk herniation or ischemia. The tissue responses by gliosis, demyelination, and axonal loss. This results in injury to the white matter (myelinated tracts) and the gray matter (cell bodies) in the cord with loss of sensory reflexes (pinprick, joint position sense, vibration, hot/cold, pressure) and motor function.[1][2]

Pathophysiology

Anatomy

Pathogenesis

References

  1. 1.0 1.1 Bican O, Minagar A, Pruitt AA (2013). "The spinal cord: a review of functional neuroanatomy". Neurol Clin. 31 (1): 1–18. doi:10.1016/j.ncl.2012.09.009. PMID 23186894.
  2. 2.0 2.1 Diaz E, Morales H (2016). "Spinal Cord Anatomy and Clinical Syndromes". Semin. Ultrasound CT MR. 37 (5): 360–71. doi:10.1053/j.sult.2016.05.002. PMID 27616310.
  3. Pekny M, Wilhelmsson U, Pekna M (2014). "The dual role of astrocyte activation and reactive gliosis". Neurosci. Lett. 565: 30–8. doi:10.1016/j.neulet.2013.12.071. PMID 24406153.
  4. Vilar-González S, Pérez-Rozos A, Torres-Campa JM, Mateos V (2013). "[Spinal cord compression: a multidisciplinary approach to a real neuro-oncological emergency]". Rev Neurol (in Spanish; Castilian). 56 (1): 43–52. PMID 23250681.
  5. Schmidt MH, Klimo P, Vrionis FD (2005). "Metastatic spinal cord compression". J Natl Compr Canc Netw. 3 (5): 711–9. PMID 16194459.

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