Hydroa vacciniforme-like lymphoma natural history, complications and prognosis: Difference between revisions
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==Natural History== | ==Natural History== | ||
In many children '''hydroa vacciniforme''' (HV) regresses spontaneously by early adulthood. In the 29 patients followed by Iwatuski et al, 11 of the 18 with definite or probable HV were available for follow-up and all were alive without progression of their symptoms. Some had recurrent eruptions of HV. In contrast out of 11 severe patients in this study, 6 had evidence of chronic EBV infection, 5 had hypersensitivity to mosquito bites, 4 had virus-associated [[hemophagocytic syndrome]]. 6 of the severe group had [[natural killer-cell]] [[lymphocytosis]] in the peripheral blood.<ref name=" | In many children '''hydroa vacciniforme''' (HV) regresses spontaneously by early adulthood. In the 29 patients followed by Iwatuski et al, 11 of the 18 with definite or probable HV were available for follow-up and all were alive without progression of their symptoms. Some had recurrent eruptions of HV. In contrast out of 11 severe patients in this study, 6 had evidence of chronic EBV infection, 5 had hypersensitivity to mosquito bites, 4 had virus-associated [[hemophagocytic syndrome]]. 6 of the severe group had [[natural killer-cell]] [[lymphocytosis]] in the peripheral blood. | ||
The main clinical characteristics are [[lymphadenopathy]], [[fever]], [[hepatosplenomegaly]] and [[skin rashes]]<ref name="pmid25197370">{{cite journal| author=Huang W, Lv N, Ying J, Qiu T, Feng X| title=Clinicopathological characteristics of four cases of EBV positive T-cell lymphoproliferative disorders of childhood in China. | journal=Int J Clin Exp Pathol | year= 2014 | volume= 7 | issue= 8 | pages= 4991-9 | pmid=25197370 | doi= | pmc=PMC4152060 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25197370 }} </ref>. | |||
==References== | ==References== | ||
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Latest revision as of 22:53, 15 February 2015
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Alberto Plate [2]
Natural History
In many children hydroa vacciniforme (HV) regresses spontaneously by early adulthood. In the 29 patients followed by Iwatuski et al, 11 of the 18 with definite or probable HV were available for follow-up and all were alive without progression of their symptoms. Some had recurrent eruptions of HV. In contrast out of 11 severe patients in this study, 6 had evidence of chronic EBV infection, 5 had hypersensitivity to mosquito bites, 4 had virus-associated hemophagocytic syndrome. 6 of the severe group had natural killer-cell lymphocytosis in the peripheral blood.
The main clinical characteristics are lymphadenopathy, fever, hepatosplenomegaly and skin rashes[1].