Hydroa vacciniforme-like lymphoma natural history, complications and prognosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Alberto Plate [2]

Natural History

In many children hydroa vacciniforme (HV) regresses spontaneously by early adulthood. In the 29 patients followed by Iwatuski et al, 11 of the 18 with definite or probable HV were available for follow-up and all were alive without progression of their symptoms. Some had recurrent eruptions of HV. In contrast out of 11 severe patients in this study, 6 had evidence of chronic EBV infection, 5 had hypersensitivity to mosquito bites, 4 had virus-associated hemophagocytic syndrome. 6 of the severe group had natural killer-cell lymphocytosis in the peripheral blood.

The main clinical characteristics are lymphadenopathy, fever, hepatosplenomegaly and skin rashes[1].


References

  1. ↑ Huang W, Lv N, Ying J, Qiu T, Feng X (2014). "Clinicopathological characteristics of four cases of EBV positive T-cell lymphoproliferative disorders of childhood in China". Int J Clin Exp Pathol. 7 (8): 4991–9. PMC 4152060. PMID 25197370.

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