View source for Interleukin 11 receptor alpha subunit

{{Infobox_gene}}
'''Interleukin 11 receptor, alpha subunit''' is a subunit of the [[interleukin 11 receptor]]. '''IL11RA''' is its human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: IL11RA interleukin 11 receptor, alpha| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3590| accessdate = }}</ref>

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{{PBB_Summary
| section_title = 
| summary_text = Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Alternative splicing has been observed at this locus and two variants, each encoding a distinct isoform, have been identified.<ref name="entrez">{{cite web | title = Entrez Gene: IL11RA interleukin 11 receptor, alpha| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3590| accessdate = }}</ref>
}}

==References==
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==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal   |vauthors=Chérel M, Sorel M, Lebeau B, etal |title=Molecular cloning of two isoforms of a receptor for the human hematopoietic cytokine interleukin-11 |journal=Blood |volume=86 |issue= 7 |pages= 2534–40 |year= 1995 |pmid= 7670098 |doi=  }}
*{{cite journal   |vauthors=Chérel M, Sorel M, Apiou F, etal |title=The human interleukin-11 receptor alpha gene (IL11RA): genomic organization and chromosome mapping |journal=Genomics |volume=32 |issue= 1 |pages= 49–53 |year= 1996 |pmid= 8786120 |doi=10.1006/geno.1996.0075  }}
*{{cite journal   |vauthors=Van Leuven F, Stas L, Hilliker C, etal |title=Molecular cloning and characterization of the human interleukin-11 receptor alpha-chain gene, IL11RA, located on chromosome 9p13 |journal=Genomics |volume=31 |issue= 1 |pages= 65–70 |year= 1996 |pmid= 8808281 |doi= 10.1006/geno.1996.0010 }}
*{{cite journal   |vauthors=Magrangeas F, Pitiot G, Dubois S, etal |title=Cotranscription and intergenic splicing of human galactose-1-phosphate uridylyltransferase and interleukin-11 receptor alpha-chain genes generate a fusion mRNA in normal cells. Implication for the production of multidomain proteins during evolution |journal=J. Biol. Chem. |volume=273 |issue= 26 |pages= 16005–10 |year= 1998 |pmid= 9632650 |doi=10.1074/jbc.273.26.16005  }}
*{{cite journal  |vauthors=Barton VA, Hudson KR, Heath JK |title=Identification of three distinct receptor binding sites of murine interleukin-11 |journal=J. Biol. Chem. |volume=274 |issue= 9 |pages= 5755–61 |year= 1999 |pmid= 10026196 |doi=10.1074/jbc.274.9.5755  }}
*{{cite journal   |vauthors=Tacken I, Dahmen H, Boisteau O, etal |title=Definition of receptor binding sites on human interleukin-11 by molecular modeling-guided mutagenesis |journal=Eur. J. Biochem. |volume=265 |issue= 2 |pages= 645–55 |year= 1999 |pmid= 10504396 |doi=10.1046/j.1432-1327.1999.00755.x  }}
*{{cite journal  |vauthors=Campbell CL, Jiang Z, Savarese DM, Savarese TM |title=Increased expression of the interleukin-11 receptor and evidence of STAT3 activation in prostate carcinoma |journal=Am. J. Pathol. |volume=158 |issue= 1 |pages= 25–32 |year= 2001 |pmid= 11141475 |doi=  10.1016/S0002-9440(10)63940-5| pmc=1850253  }}
*{{cite journal  |vauthors=Cork BA, Tuckerman EM, Li TC, Laird SM |title=Expression of interleukin (IL)-11 receptor by the human endometrium in vivo and effects of IL-11, IL-6 and LIF on the production of MMP and cytokines by human endometrial cells in vitro |journal=Mol. Hum. Reprod. |volume=8 |issue= 9 |pages= 841–8 |year= 2003 |pmid= 12200462 |doi=10.1093/molehr/8.9.841  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal   |vauthors=Karpovich N, Chobotova K, Carver J, etal |title=Expression and function of interleukin-11 and its receptor alpha in the human endometrium |journal=Mol. Hum. Reprod. |volume=9 |issue= 2 |pages= 75–80 |year= 2003 |pmid= 12569176 |doi=10.1093/molehr/gag012  | pmc=1626582  }}
*{{cite journal   |vauthors=Kiessling S, Muller-Newen G, Leeb SN, etal |title=Functional expression of the interleukin-11 receptor alpha-chain and evidence of antiapoptotic effects in human colonic epithelial cells |journal=J. Biol. Chem. |volume=279 |issue= 11 |pages= 10304–15 |year= 2004 |pmid= 14701802 |doi= 10.1074/jbc.M312757200 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Zurita AJ, Troncoso P, Cardó-Vila M, etal |title=Combinatorial screenings in patients: the interleukin-11 receptor alpha as a candidate target in the progression of human prostate cancer |journal=Cancer Res. |volume=64 |issue= 2 |pages= 435–9 |year= 2004 |pmid= 14744752 |doi=10.1158/0008-5472.CAN-03-2675  }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal   |vauthors=Tsimanis A, Shtalrid M, Shvidel L, etal |title=Expression of interleukin-11 receptor in CD38-positive cells from patients with multiple myeloma |journal=Leuk. Lymphoma |volume=45 |issue= 11 |pages= 2315–9 |year= 2005 |pmid= 15512823 |doi= 10.1080/10428190412331283161 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal   |vauthors=Karube K, Ohshima K, Suzumiya J, etal |title=Gene expression profile of cytokines and chemokines in microdissected primary Hodgkin and Reed-Sternberg (HRS) cells: high expression of interleukin-11 receptor alpha |journal=Ann. Oncol. |volume=17 |issue= 1 |pages= 110–6 |year= 2006 |pmid= 16291580 |doi= 10.1093/annonc/mdj064 }}
*{{cite journal   |vauthors=Hanavadi S, Martin TA, Watkins G, etal |title=Expression of interleukin 11 and its receptor and their prognostic value in human breast cancer |journal=Ann. Surg. Oncol. |volume=13 |issue= 6 |pages= 802–8 |year= 2006 |pmid= 16614887 |doi= 10.1245/ASO.2006.05.028 }}
*{{cite journal   |vauthors=Yoshizaki A, Nakayama T, Yamazumi K, etal |title=Expression of interleukin (IL)-11 and IL-11 receptor in human colorectal adenocarcinoma: IL-11 up-regulation of the invasive and proliferative activity of human colorectal carcinoma cells |journal=Int. J. Oncol. |volume=29 |issue= 4 |pages= 869–76 |year= 2006 |pmid= 16964382 |doi=  10.3892/ijo.29.4.869}}
*{{cite journal   |vauthors=Nakayama T, Yoshizaki A, Izumida S, etal |title=Expression of interleukin-11 (IL-11) and IL-11 receptor alpha in human gastric carcinoma and IL-11 upregulates the invasive activity of human gastric carcinoma cells |journal=Int. J. Oncol. |volume=30 |issue= 4 |pages= 825–33 |year= 2007 |pmid= 17332920 |doi=  10.3892/ijo.30.4.825}}
}}
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{{Cytokine receptors}}
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