View source for Autoimmune disease

{{Infobox Disease |
  Name           = Autoimmune diseases |
  Image          = |
  Caption        = |
  DiseasesDB     = 28805 |
  ICD10          = |
  ICD9           = {{ICD9|279.4}} |
  ICDO           = |
  OMIM           = 109100 |
  MedlinePlus    = 000816 |
  eMedicineSubj  = |
  eMedicineTopic = |
  MeshID         = D001327 |
}}
{{SI}}

{{CMG}}


==Overview==

'''Autoimmune diseases''' arise from an overactive [[immune response]] of the body against substances and tissues normally present in the body. In other words, the body attacks its own cells. This may be restricted to certain organs (e.g. in [[thyroiditis]]) or involve a particular tissue in different places (e.g. [[Goodpasture's disease]] which may affect the [[basement membrane]] in both the lung and the kidney). The treatment of autoimmune diseases is typically with [[immunosuppression]]&mdash;medication which decreases the immune response.

==Occurrence and onset ==
[[Hormone]] levels have been shown to affect the severity of some autoimmune diseases such as [[multiple sclerosis]].<ref>{{cite web |url=http://www.sciencemag.org/feature/data/983519.shl |title=A Gender Gap in Autoimmunity  |accessdate=2007-10-19 |format= |work=}}</ref>  Other causes may include the presence of fetal cells in the maternal bloodstream, i.e. microchimerism. <ref>{{cite web |url=http://jama.ama-assn.org/cgi/content/abstract/291/9/1127 |title=JAMA -- Abstract: Microchimerism: An Investigative Frontier in Autoimmunity and Transplantation, March 3, 2004, Adams and Nelson 291 (9): 1127 |accessdate=2007-10-19 |format= |work=}}</ref>

==Autoimmune diseases==

It is possible to classify autoimmune diseases by corresponding type of [[hypersensitivity]]: [[Type II hypersensitivity|type II]], [[Type III hypersensitivity|type III]], or [[Type IV hypersensitivity|type IV]]. (No type of autoimmune disease mimics [[type I hypersensitivity]].)<ref name="isbn0-8153-4093-1">{{cite book |author=Parham, Peter |title=The immune system |publisher=Garland Science |location=New York |year=2005 |pages=344 |isbn=0-8153-4093-1 |oclc= |doi= |accessdate=}}</ref>

{| class="wikitable" class="sortable wikitable"
| '''Name''' || '''Accepted/<BR>suspected''' || '''[[Hypersensitivity]]''' || '''[[Autoantibody]]'''
|- 
 |  [[Acute disseminated encephalomyelitis]] (ADEM)  || Accepted<ref name="Mesh">{{MeshName|Autoimmune+Diseases}}</ref>  ||  
 |- 
 |  [[Addison's disease]]  || Accepted<ref name = "Mesh"/>   ||  
 |- 
 |  [[Alopecia areata]]  || Accepted<ref name = "Mesh"/>   ||  
 |- 
 |  [[Ankylosing spondylitis]]  || Doubtful<ref name = "Mesh"/>   ||  
 |- 
 |  [[Antiphospholipid antibody syndrome]] (APS)  || Accepted<ref name = "Mesh"/>   ||  
 |- 
 |  [[Autoimmune hemolytic anemia]] || Accepted<ref name = "urlAutoimmune Disorders: Immune Disorders: Merck Manual Home Edition"/>  || II 
 |- 
 |  [[Autoimmune hepatitis]]  || Accepted<ref name = "Mesh"/>   ||  || [[Anti-Smooth Muscle Actin]]
 |- 
 |  [[Autoimmune inner ear disease]]   ||  Suspected<ref name="urlAutoimmune Inner Ear Disease">{{cite web
|url=http://www.bcm.edu/oto/grand/4893.html
|title=Autoimmune Inner Ear Disease, Baylor College of Medicine|year=1993}}
</ref>  ||  
 |-
 |  [[Bullous pemphigoid]] || Accepted<ref name = "urlAutoimmune Disorders: Immune Disorders: Merck Manual Home Edition"/>  ||  II || [[Anti-Bullous Pemphigoid Antigen 1 and 2 (Hemidesmosome antigens)]]
 |- 
 |  [[Coeliac disease]]  || Accepted<ref name="urlCeliac Disease">{{cite web |url=http://digestive.niddk.nih.gov/ddiseases/pubs/celiac/#1 |title=Celiac Disease |format= |work= |accessdate=}}</ref><ref name="pmid16234635">{{cite journal |author=Meize-Grochowski R |title=Celiac disease: a multisystem autoimmune disorder |journal=Gastroenterol Nurs |volume=28 |issue=5 |pages=394–402; quiz 403–4 |year=2005 |pmid=16234635 |doi= 10.1097/00001610-200509000-00005|url=http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?issn=1042-895X&volume=28&issue=5&spage=394}}</ref><ref name="pmid16214317">{{cite journal |author=Sollid LM, Jabri B |title=Is celiac disease an autoimmune disorder? |journal=Curr. Opin. Immunol. |volume=17 |issue=6 |pages=595–600 |year=2005 |month=December |pmid=16214317 |doi=10.1016/j.coi.2005.09.015 |url=http://linkinghub.elsevier.com/retrieve/pii/S0952-7915(05)00158-5}}</ref>  || IV?? || [[Anti-transglutaminase antibodies|Anti-transglutaminase]]
 |- 
 |  [[Chagas disease]]  || Suspected<ref>{{cite journal |author=Hyland KV, Engman DM |title=Further thoughts on where we stand on the autoimmunity hypothesis of Chagas disease |journal=Trends Parasitol. |volume=22 |issue=3 |pages=101–2; author reply 103 |year=2006 |pmid=16446117 |doi=10.1016/j.pt.2006.01.001}}</ref>  ||  
 |- 
 |  [[Chronic obstructive pulmonary disease]] || Suspected<ref name="PMID14514931">{{cite journal |author=Agustí A, MacNee W, Donaldson K, Cosio M. |title=Hypothesis: does COPD have an autoimmune component? |journal=Thorax |volume=58 |issue=10 |pages=832–834 |year=2003 |pmid=14514931 |doi=10.1136/thorax.58.10.832}}</ref> <ref name="pmid17450149">{{cite journal |author=Lee SH, Goswami S, Grudo A, ''et al'' |title=Antielastin autoimmunity in tobacco smoking-induced emphysema |journal=Nat. Med. |volume=13 |issue=5 |pages=567–9 |year=2007 |pmid=17450149 |doi=10.1038/nm1583}}</ref>  ||  
 |-
 |  [[Crohns Disease]] (one of two types of idiopathic inflammatory bowel disease "IBD")  || Accepted<ref name="Mesh" />   ||  IV ||
 |-
 |  [[Dermatomyositis]]  || Accepted<ref name = "urlPolymyositis and Dermatomyositis: Autoimmune Disorders of Connective Tissue: Merck Manual Home Edition"/>  ||  
 |- 
 |  [[Diabetes mellitus type 1]]  || Accepted<ref name = "Mesh"/>   || IV 
 |- 
 |  [[Endometriosis]]  || Suspected<ref>{{cite journal |author=Gleicher N, el-Roeiy A, Confino E, Friberg J |title=Is endometriosis an autoimmune disease? |journal=Obstetrics and gynecology |volume=70 |issue=1 |pages=115–22 |year=1987 |pmid=3110710 |doi=}}</ref>  ||  
 |- 
 |  [[Goodpasture's syndrome]]  || Accepted<ref name = "Mesh"/>   || II || [[Anti-Basement Membrane Collagen Type IV Protein]]
 |- 
 |  [[Graves' disease]]  || Accepted<ref name = "Mesh"/>   || II 
 |- 
 |  [[Guillain-Barré syndrome]] (GBS)  || Accepted<ref name = "Mesh"/>   || IV  || [[Anti-ganglioside antibodies|Anti-ganglioside]]
 |- 
 |  [[Hashimoto's disease]]  || Accepted<ref name = "Mesh"/>   || IV || 
 |- 
 |  [[Hidradenitis suppurativa]]  || Suspected<ref>{{cite web |url=http://clinicaltrials.gov/show/NCT00329823 |title=Clinical Trial: Etanercept in Hidradenitis Suppurativa |accessdate=2007-07-08 |format= |work=}}</ref>  ||  
 |-
 |  [[Kawasaki disease]]  || Suspected ||
 |- 
 |  [[IgA nephropathy]]  || Suspected ||
 |- 
 |  [[Idiopathic thrombocytopenic purpura]]  || Accepted<ref name = "Mesh"/>   || II
 |- 
 |  [[Interstitial cystitis]]  || Suspected<ref>{{cite journal |author=Kárpáti F, Dénes L, Büttner K |title=[Interstitial cystitis=autoimmune cyatitis? Interstitial as a participating disease in lupus erythematosus] |language=German |journal=Zeitschrift für Urologie und Nephrologie |volume=68 |issue=9 |pages=633–9 |year=1975 |pmid=1227191 |doi=}}</ref>  ||  
 |- 
 |  [[Lupus erythematosus]]  || Accepted<ref name = "Mesh"/>   || III 
 |- 
 |  [[Mixed Connective Tissue Disease]]  || Accepted<ref name = "Mesh"/>   ||
 |- 
 |  [[Morphea]] || Suspected<ref name="pmid15561734">{{cite journal |author=Takehara K, Sato S |title=Localized scleroderma is an autoimmune disorder |journal=Rheumatology (Oxford, England) |volume=44 |issue=3 |pages=274–9 |year=2005 |pmid=15561734 |doi=10.1093/rheumatology/keh487}}</ref>  ||  
 |- 
 |  [[Multiple sclerosis]] (MS)  || Accepted<ref name = "Mesh"/>   || IV  || [[Anti-Myelin Basic Protein]]
 |- 
 |  [[Myasthenia gravis]]  || Accepted<ref name = "Mesh"/>   || II 
 |- 
 |  [[Narcolepsy]]  || Suspected<ref>{{cite journal | author=Carlander, B., Eliaou J.F., Billiard M. | title=Autoimmune hypothesis in narcolepsy. | journal=Neurophysiol. Clin. | volume=23 | year=1993 | doi=10.1016/S0987-7053(05)80279-5 | pages=15}} </ref>  ||  
 |- 
 |  [[Neuromyotonia]]  || Suspected<ref>{{cite journal |author=Maddison P |title=Neuromyotonia |journal=Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology |volume=117 |issue=10 |pages=2118–27 |year=2006 |pmid=16843723 |doi=10.1016/j.clinph.2006.03.008}}</ref>  ||  
 |- 
 |  [[Pemphigus Vulgaris]]  || Accepted<ref name = "Mesh"/>   || II || [[Anti-Desmogein 3]]
 |- 
 |  [[Pernicious anaemia]] || Accepted<ref name="titleMedlinePlus Medical Encyclopedia: Pernicious anemia">{{cite web |url=http://www.nlm.nih.gov/medlineplus/ency/article/000569.htm |title=MedlinePlus Medical Encyclopedia: Pernicious anemia |accessdate=2008-04-05 |format= |work=}}</ref>   ||  II || 
 |- 
 |  [[Psoriasis]]  || Suspected<ref>National Psoriasis Foundation, http://www.psoriasis.org/home/learn01.php</ref>   ||  || 
 |- 
 |  [[Psoriatic Arthritis]]  || Suspected<ref>National Psoriasis Foundation, http://www.psoriasis.org/home/learn02.php</ref>   ||  || 
 |- 
 |  [[Polymyositis]]  || Accepted<ref name="urlPolymyositis and Dermatomyositis: Autoimmune Disorders of Connective Tissue: Merck Manual Home Edition">{{cite web |url=http://www.merck.com/mmhe/sec05/ch068/ch068e.html |title=Polymyositis and Dermatomyositis: Autoimmune Disorders of Connective Tissue: Merck Manual Home Edition |format= |work= |accessdate=}}</ref>  ||  
 |- 
 |  [[Primary biliary cirrhosis]] || Accepted<ref name="titlePrimary Biliary Cirrhosis: Fatty Liver, Cirrhosis, and Related Disorders: Merck Manual Home Edition">{{cite web |url=http://www.merck.com/mmhe/sec10/ch136/ch136d.html |title=Primary Biliary Cirrhosis: Fatty Liver, Cirrhosis, and Related Disorders: Merck Manual Home Edition |accessdate=2008-04-05 |format= |work=}}</ref>   ||  || [[Anti-p62 antibodies|Anti-p62]], [[Anti-sp100 antibodies|Anti-sp100]], [[Anti-Mitochontrial(M@) antibodys|Anti-Mitochondrial(M2)]]
 |- 
 |  [[Rheumatoid arthritis]] || Accepted<ref name="Mesh"/>   || III || [[Rheumatoid factor]]
 |- 
 |  [[Schizophrenia]]   || Suspected<ref>{{cite journal |author=Eaton WW, Byrne M, Ewald H, ''et al'' |title=Association of schizophrenia and autoimmune diseases: linkage of Danish national registers |journal=The American journal of psychiatry |volume=163 |issue=3 |pages=521–8 |year=2006 |pmid=16513876 |doi=10.1176/appi.ajp.163.3.521}}</ref><ref>{{cite journal |author=Jones AL, Mowry BJ, Pender MP, Greer JM |title=Immune dysregulation and self-reactivity in schizophrenia: do some cases of schizophrenia have an autoimmune basis? |journal=Immunol. Cell Biol. |volume=83 |issue=1 |pages=9–17 |year=2005 |pmid=15661036 |doi=10.1111/j.1440-1711.2005.01305.x}}</ref><ref>{{cite journal |author=Strous RD, Shoenfeld Y |title=Schizophrenia, autoimmunity and immune system dysregulation: a comprehensive model updated and revisited |journal=J. Autoimmun. |volume=27 |issue=2 |pages=71–80 |year=2006 |pmid=16997531 |doi=10.1016/j.jaut.2006.07.006}}</ref>  ||  
 |- [[Sarcoidosis]] 
 |  [[Scleroderma]]  || Suspected<ref name="pmid15561734"/>  || || [[Anti-topoisomerase antibodies|Anti-topoisomerase]]
 |- 
 |  [[Sjögren's syndrome]]  || Accepted<ref name = "Mesh"/>   ||  
|- 
 |  [[Stiff person syndrome]]  || Suspected||  
 |- 
 |  [[Temporal arteritis]] (also known as "giant cell arteritis")  || Accepted<ref name="Mesh" />   ||  IV ||
 |-
 |  [[Ulcerative Colitis]] (one of two types of idiopathic inflammatory bowel disease "IBD")  || Accepted<ref name="Mesh" />   ||  IV ||
 |- 
 |  [[Vasculitis]] || Accepted<ref name="urlAutoimmune Disorders: Immune Disorders: Merck Manual Home Edition">{{cite web |url=http://www.merck.com/mmhe/sec16/ch186/ch186a.html |title=Autoimmune Disorders: Immune Disorders: Merck Manual Home Edition |format= |work= |accessdate=}}</ref>  || III
 |- 
 |  [[Vitiligo]]  || Suspected<ref>{{cite web |url=http://www.niams.nih.gov/hi/topics/vitiligo/vitiligo.htm |title=Questions and Answers about Vitiligo |accessdate=2007-08-06 |format= |work=}}</ref><ref>{{cite web |url=http://dermatology.jwatch.org/cgi/content/full/2007/330/1 |title=A New Gene Linked to Vitiligo and Susceptibility to Autoimmune Disorders - Journal Watch Dermatology |accessdate=2007-08-06 |format= |work=}}</ref>  ||  
 |- 
 |  [[Wegener's granulomatosis]]  || Accepted<ref name="pmid18391678">{{cite journal |author=Sánchez-Cano D, Callejas-Rubio JL, Ortego-Centeno N |title=Effect of rituximab on refractory Wegener granulomatosis with predominant granulomatous disease |journal=J Clin Rheumatol |volume=14 |issue=2 |pages=92–3 |year=2008 |month=April |pmid=18391678 |doi=10.1097/RHU.0b013e31816b4487 |url=http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?an=00124743-200804000-00008 }}</ref>  ||  || [[Anti-neutrophil cytoplasmic antibody|Anti-neutrophil cytoplasmic(cANCA)]]
|}

==Development of therapies==
In both autoimmune and inflammatory diseases the condition arises through aberrant reactions of the human adaptive or innate immune systems. In autoimmunity, the patient’s immune system is activated against the body's own proteins. In inflammatory diseases, it is the overreaction of the immune system, and its subsequent downstream signaling (TNF, IFN, etc), which causes problems.

A substantial minority of the population suffers from these diseases, which are often chronic, debilitating, and life-threatening. There are more than eighty illnesses caused by autoimmunity. It has been estimated that autoimmune diseases are among the ten leading causes of death among women in all age groups up to 65 years.<ref>Noel R. Rose and Ian R. MacKay, “The Autoimmune Diseases” fourth edition</ref>

Currently, a considerable amount of research is being conducted into treatment of these conditions. According to a report from Frost & Sullivan, the total alliance payouts in the autoimmune/inflammation segment from 1997 to 2002 totaled $489.8 million, where Eli Lilly, Suntory, Procter & Gamble, Encysive, and Novartis together account for 98.6 percent of alliance payouts.<ref>Frost & Sullivan Report, “Antibody Technology Developments” September 2005</ref>

==References==
{{Reflist|2}}

==External links==
* {{DMOZ|/Health/Conditions_and_Diseases/Immune_Disorders/Auto-Immune/|Auto-immune disorders}}
* [http://www.lib.uiowa.edu/hardin/md/autoimmune.html Links to pictures of Autoimmune Diseases (Hardin MD) at University of Iowa]

==See also==
*[[Systemic autoimmune diseases]]

* [[Autoimmunity]]

{{Immune disorders}}
{{Autoimmune diseases}}



[[Category:Autoimmune diseases| ]]



[[de:Autoimmunerkrankung]]
[[es:Enfermedad autoinmune]]
[[fr:Maladie auto-immune]]
[[hr:Autoimune bolesti]]
[[he:מחלת חיסון עצמי]]
[[nl:Auto-immuunziekte]]
[[pl:Choroby autoimmunologiczne]]
[[ru:Аутоиммунные заболевания]]
[[sk:Autoimunitná choroba]]
[[fi:Autoimmuunisairaus]]
[[tr:Otoimmün hastalık]]
[[uk:Автоімунітет]]

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