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Author [[PageAuthor::Mohamed Moubarak, M.D. [1]]]
Exam Type ExamType::USMLE Step 3
Main Category MainCategory::Primary Care Office
Sub Category SubCategory::Endocrine, SubCategory::Endocrine
Prompt [[Prompt::A 35 year-old female comes to your office for follow up after being diagnosed with type 2 diabetes mellitus 1 month ago. She has been following a diet and exercise beside her metformin as an oral hypoglycemic therapy. The patient is hypertensive with blood pressure 160/90 mmHg on beta blockers, and smokes ½ pack per day for 10 years. Her labs have been sent to your office and shows:
  • Total blood cholesterol of 270mg/dL
  • LDL of 190mg/dL
  • HDL of 28 mg/dL
  • HgbA1C 9.8%
  • ALT 15 IU/L
  • AST 10 IU/L

In addition to diet, exercise, and smoking cessation, which of the following would have the greatest effect in reducing her cholesterol?]]

Answer A AnswerA::Controlling her blood pressure
Answer A Explanation [[AnswerAExp::Incorrect

Controlling blood pressure has no known direct effect on lipid profile]]

Answer B AnswerB::Controlling her diabetes mellitus
Answer B Explanation [[AnswerBExp::Correct

By controlling her diabetes mellitus, will lowering LDL and triglyceride levels and, therefore, decreasing total cholesterol]]

Answer C AnswerC::Adding alcoholic beverages twice per day
Answer C Explanation [[AnswerCExp::Incorrect

Alcohol cannot be used as main line in the treatment of high lipid profile]]

Answer D AnswerD::Improving her sleeping habits
Answer D Explanation [[AnswerDExp::Incorrect

Sleeping will not reduce her lipid profile.]]

Answer E AnswerE::Adding thyroid hormone to her medications.
Answer E Explanation [[AnswerEExp::Incorrect

The patient has no symptoms of hypothyroidism, and although thyroid hormone helps reducing the lipid level, it shouldn’t be used unless there are symptoms.]]

Right Answer RightAnswer::B
Explanation [[Explanation::Diabetes mellitus control would positively affect the lipid profile by lowering LDL and triglyceride levels and, therefore, decreasing total cholesterol

Educational Objective:
References: ]]

Approved Approved::No
Keyword [[WBRKeyword::Diabetes mellitus]], [[WBRKeyword::Hypercholesterolemia]]
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