Urticaria differential diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Differentiating Urticaria from other Diseases

• Hereditary or acquired deficiency of compliment factor C1
• Cutaneous mastocytosis/urticaria pigmentosa
• Malignancy
• Poison ivy contact dermatitis: The rash that develops from poison ivy, poison oak, and poison sumac contact is commonly mistaken for urticaria. This rash is caused by contact with urushiol and results in a form of contact dermatitis called Urushiol-induced contact dermatitis. Urushiol is spread by contact, but can be washed off with a strong grease/oil dissolving detergent and cool water.
• Angioedema: It is related to urticaria. In angioedema, the swelling occurs in a lower layer of the dermis than it does in urticaria. This swelling can occur around the mouth, in the throat, in the abdomen, or in other locations. Urticaria and angioedema sometimes occur together in response to an allergen and is a concern in severe cases because angioedema of the throat can be fatal.