Transmembrane domain of ABC transporters
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| ABC transporter transmembrane region | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | ABC_membrane | ||||||||
| Pfam | PF00664 | ||||||||
| InterPro | IPR001140 | ||||||||
| PROSITE | PDOC00364 | ||||||||
| SCOP | 1pf4 | ||||||||
| SUPERFAMILY | 1pf4 | ||||||||
| TCDB | 3.A.1 | ||||||||
| OPM superfamily | 18 | ||||||||
| OPM protein | 1pf4 | ||||||||
| |||||||||
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
ABC transporter transmembrane domain is main transmembrane structural unit of ATP-binding cassette transporter which consist of six transmembrane domaines. Many members of the ABC transporter family (Pfam PF00005) have two such regions.[1].[2][3][4][5][6]
Human proteins containing this domain
ABCB1; ABCB10; ABCB11; ABCB4; ABCB5; ABCB6; ABCB7; ABCB8; ABCB9; ABCC1; ABCC10; ABCC11; ABCC12; ABCC13; ABCC2; ABCC3; ABCC4; ABCC5; ABCC6; ABCC8; ABCC9; CFTR; LOC402251; MRP3; TAP1; TAP2; TAPL; ara;
References
- ↑ Kerr ID (2002). "Structure and association of ATP-binding cassette transporter nucleotide-binding domains". Biochim. Biophys. Acta. 1561 (1): -. PMID 11988180.
- ↑ Hunt JF, Yuan YR, Martsinkevich O, Millen L, Thomas PJ, Karpowich N, Dai PL, MacVey K (2001). "Crystal structures of the MJ1267 ATP binding cassette reveal an induced-fit effect at the ATPase active site of an ABC transporter". Structure. 9 (7): -. PMID 11470432.
- ↑ Hunt JF, Yuan YR, Blecker S, Martsinkevich O, Millen L, Thomas PJ (2001). "The crystal structure of the MJ0796ATP-binding cassette. Implications for the structural consequences of ATP hydrolysis in the active site of an ABC transporter". J. Biol. Chem. 276 (34): -. PMID 11402022.
- ↑ Kim SH, Hung LW, Wang IX, Nikaido K, Liu PQ, Ames GF (1998). "Crystal structure of the ATP-binding subunit of an ABC transporter". Nature. 396 (6712): 703–707. PMID 9872322.
- ↑ Welte W, Breed J, Boos W, Diederichs K, Vonrhein C, Muller C, Diez J, Greller G, Schnell C (2000). "Crystal structure of MalK, the ATPase subunit of the trehalose/maltose ABC transporter of the archaeon Thermococcus litoralis". EMBO J. 19 (22): -. PMID 11080142.
- ↑ Wiley DC, Gaudet R (2001). "Structure of the ABC ATPase domain of human TAP1, the transporter associated with antigen processing". EMBO J. 20 (17): -. PMID 11532960.