Toxic megacolon epidemiology and demographics
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Farima Kahe M.D. [2]
Overview
The precise incidence of toxic megacolon is unknown in general population. The incidence of toxic megacolon in the associated disorders including ulcerative colitis and Crohn's disease is 1000-2500 in 100,000 cases and 4400-6300 in 100,000 cases, respectively. The mortality rate of toxic megacolon associated with Clostridium difficile is approximately 38%-80%.
Epidemiology and Demographics
Incidence
- The precise incidence of toxic megacolon is unknown in general population. The incidence of toxic megacolon in the associated disorders including ulcerative colitis, Crohn's disease and Clostridium difficile is:[1][2][3]
- 1000-2500 in 100,000 cases of the ulcerative colitis.
- 4400-6300 in 100,000 cases of the Crohn's disease.
- 400-3000 in 100,000 cases of the Clostridium difficile.
Mortality rate
- The mortality rate of toxic megacolon associated with clostridium difficile is approximately 38%-80%.[4][5]
Age
- Patients of all age groups may develop toxic megacolon.[6]
Race
- There is no racial predilection described in toxic megacolon.[7]
Gender
- Toxic megacolon affects men and women equally.[8]
References
- ↑ Gan, S. Ian; Beck, P. L. (2003). "A new look at toxic megacolon: an update and review of incidence, etiology, pathogenesis, and management". The American Journal of Gastroenterology. 98 (11): 2363–2371. doi:10.1111/j.1572-0241.2003.07696.x. ISSN 0002-9270.
- ↑ Grieco MB, Bordan DL, Geiss AC, Beil AR (1980). "Toxic megacolon complicating Crohn's colitis". Ann. Surg. 191 (1): 75–80. PMC 1344622. PMID 7352781.
- ↑ Sayedy, Leena (2010). "Toxic megacolon associatedClostridium difficilecolitis". World Journal of Gastrointestinal Endoscopy. 2 (8): 293. doi:10.4253/wjge.v2.i8.293. ISSN 1948-5190.
- ↑ Hall JF, Berger D (2008). "Outcome of colectomy for Clostridium difficile colitis: a plea for early surgical management". Am. J. Surg. 196 (3): 384–8. doi:10.1016/j.amjsurg.2007.11.017. PMID 18519126.
- ↑ Earhart MM (2008). "The identification and treatment of toxic megacolon secondary to pseudomembranous colitis". Dimens Crit Care Nurs. 27 (6): 249–54. doi:10.1097/01.DCC.0000338869.70035.2b. PMID 18953191.
- ↑ Sheth SG, LaMont JT (1998). "Toxic megacolon". Lancet. 351 (9101): 509–13. doi:10.1016/S0140-6736(97)10475-5. PMID 9482465.
- ↑ Rubin MS, Bodenstein LE, Kent KC (1995). "Severe Clostridium difficile colitis". Dis. Colon Rectum. 38 (4): 350–4. PMID 7720439.
- ↑ Gan SI, Beck PL (2003). "A new look at toxic megacolon: an update and review of incidence, etiology, pathogenesis, and management". Am. J. Gastroenterol. 98 (11): 2363–71. doi:10.1111/j.1572-0241.2003.07696.x. PMID 14638335.