Tetrahydrofolic acid

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Tetrahydrofolic acid is a folic acid derivative.


Tetrahydrofolate synthesis pathway

It is produced from dihydrofolic acid by dihydrofolate reductase. This reaction is inhibited by trimethoprim.

It is converted into 5,10-methylenetetrahydrofolate by serine hydroxymethyltransferase.


It is a coenzyme in many reactions, especially in the metabolism of amino acids and nucleic acids. It acts as a donor of a group with one carbon atom. It gets this carbon atom by sequestering formaldehyde produced in other processes. A shortage in THF can cause anemia.

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