Synovial sarcoma laboratory findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Laboratory Findings

The diagnosis of synovial sarcoma is made by histology, immunohistochemistry and, if necessary and possible, by demonstration of t(X;18). Based on histology; there are three major histologic subtypes: monophasic (consisting on sheets of spindle cells), biphasic (spindle cells admixed with areas of epithelial differentiation) and poorly differentiated.