Sulfadoxine
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| E number | {{#property:P628}} |
| ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value). |
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| Formula | C12H14N4O4S |
| Molar mass | 310.33 g/mol |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Sulfadoxine (also spelled sulphadoxine) is an ultra-long-lasting sulfonamide previously used in combination with pyrimethamine to treat or prevent malaria.[1] Due to high levels of resistance, its use is no longer recommended routinely.[2] It is also used, usually in combination with other drugs, to treat or prevent various infections in livestock.[3]
It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.[4]
Mechanism of action
Sulfadoxine competitively inhibits dihydropteroate synthase, interfering with folate synthesis.
Synthesis
![700px U.S. Patent 3,132,139 BE 618639 [5][6]](/index.php/File:Sulfadoxine_Syn.png)
See also
References
- ↑ Medical Treatment - Sulphadoxine and Pyrimethamine.
- ↑ Matondo SI, Temba GS, Kavishe AA; et al. (2014). "High levels of sulphadoxine-pyrimethamine resistance Pfdhfr-Pfdhps quintuple mutations: a cross sectional survey of six regions in Tanzania". Malar J. 13: 152. doi:10.1186/1475-2875-13-152. PMC 3998221. PMID 24751352.
- ↑ http://en.scientificcommons.org/19483411.
- ↑ "WHO Model List of EssentialMedicines" (PDF). World Health Organization. October 2013. Retrieved 22 April 2014.
- ↑ Template:Cite doi
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- Drug
- Anilines
- Ethers
- Pyrimidines
- Sulfonamide antibiotics
- Dihydropteroate synthetase inhibitors
- Antimalarial agents