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It has been suggested that this article be merged with Neuraminidase. (Discuss) Proposed since May 2007.
Sialidase, accession number PF02973 is a widespread enzyme that catalyzes the hydrolysis of terminal acylneuraminic residues from oligosaccharides, glycolipids and glycoproteins. Also called neuraminidase.
It is present as a surface antigen in myxo viruses, hence sialidase inhibitors are used in anti-viral drugs.
Deficiency of this enzyme, an autosomal recessive trait, causes sialidosis; enzyme activity is also lacking in galactosialidosis. The EC nomenclature is exo-α-sialidase.
- ↑ 1: Mol Gen Genet. 1991 Apr;226(1-2):190-7. The sialidase gene from Clostridium septicum: cloning, sequencing, expression in Escherichia coli and identification of conserved sequences in sialidases and other proteins Rothe B, Rothe B, Roggentin P, Schauer R.; Biochemisches Institut, Christian-Albrechts-Universitat zu Kiel, FRG.
- Sialidase at the US National Library of Medicine Medical Subject Headings (MeSH)
- EC 184.108.40.206