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Sialidase, accession number PF02973 is a widespread enzyme that catalyzes the hydrolysis of terminal acylneuraminic residues from oligosaccharides, glycolipids and glycoproteins. Also called neuraminidase.

It is present as a surface antigen in myxo viruses, hence sialidase inhibitors are used in anti-viral drugs.[1]

Deficiency of this enzyme, an autosomal recessive trait, causes sialidosis; enzyme activity is also lacking in galactosialidosis. The EC nomenclature is exo-α-sialidase.



  1. 1: Mol Gen Genet. 1991 Apr;226(1-2):190-7. The sialidase gene from Clostridium septicum: cloning, sequencing, expression in Escherichia coli and identification of conserved sequences in sialidases and other proteins Rothe B, Rothe B, Roggentin P, Schauer R.; Biochemisches Institut, Christian-Albrechts-Universitat zu Kiel, FRG.

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