Synaptogyrin-1 is a protein that in humans is encoded by the SYNGR1gene.[1][2][3]
This gene encodes an integral membrane protein associated with presynaptic vesicles in neuronal cells. The exact function of this protein is unclear, but studies of a similar murine protein suggest that it functions in synaptic plasticity without being required for synaptic transmission. The gene product belongs to the synaptogyrin gene family. Three alternatively spliced variants encoding three different isoforms have been identified.[3]
References
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↑Janz R, Sudhof TC, Hammer RE, Unni V, Siegelbaum SA, Bolshakov VY (Jan 2000). "Essential roles in synaptic plasticity for synaptogyrin I and synaptophysin I". Neuron. 24 (3): 687–700. doi:10.1016/S0896-6273(00)81122-8. PMID10595519.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID10591208.
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Verma R, Chauhan C, Saleem Q, et al. (2004). "A nonsense mutation in the synaptogyrin 1 gene in a family with schizophrenia". Biol. Psychiatry. 55 (2): 196–9. doi:10.1016/j.biopsych.2003.10.012. PMID14732601.
Verma R, Kubendran S, Das SK, et al. (2006). "SYNGR1 is associated with schizophrenia and bipolar disorder in southern India". J. Hum. Genet. 50 (12): 635–40. doi:10.1007/s10038-005-0307-z. PMID16215643.
Cheng MC, Chen CH (2007). "Identification of rare mutations of synaptogyrin 1 gene in patients with schizophrenia". Journal of Psychiatric Research. 41 (12): 1027–31. doi:10.1016/j.jpsychires.2006.08.010. PMID17049558.
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