SIGIRR

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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View/Edit Human

Single Ig IL-1-related receptor is a protein that in humans is encoded by the SIGIRR gene.[1][2]

It has been observed to modulate immune responses, colonic epithelial homeostasis and tumorigenesis.[3][4]

Interactions

SIGIRR has been shown to interact with TRAF6.[3]

References

  1. Thomassen E, Renshaw BR, Sims JE (Jul 1999). "Identification and characterization of SIGIRR, a molecule representing a novel subtype of the IL-1R superfamily". Cytokine. 11 (6): 389–99. doi:10.1006/cyto.1998.0452. PMID 10346978.
  2. "Entrez Gene: SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain".
  3. 3.0 3.1 Wald D, Qin J, Zhao Z, Qian Y, Naramura M, Tian L, Towne J, Sims JE, Stark GR, Li X (September 2003). "SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling". Nat. Immunol. 4 (9): 920–7. doi:10.1038/ni968. PMID 12925853.
  4. Xiao H, Gulen MF, Qin J, Yao J, Bulek K, Kish D, Altuntas CZ, Wald D, Ma C, Zhou H, Tuohy VK, Fairchild RL, de la Motte C, Cua D, Vallance BA, Li X (April 2007). "The Toll-interleukin-1 receptor member SIGIRR regulates colonic epithelial homeostasis, inflammation, and tumorigenesis". Immunity. 26 (4): 461–75. doi:10.1016/j.immuni.2007.02.012. PMID 17398123.

Further reading