SEMA4A is a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in guidance of axonal migration during neuronal development and in immune responses.[supplied by OMIM][2]
Clinical significance
A germline variant in SEMA4A (V78M) has been demonstrated to confer risk for colorectal cancer type X.[3]
References
↑Püschel AW, Adams RH, Betz H (Jun 1995). "Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension". Neuron. 14 (5): 941–8. doi:10.1016/0896-6273(95)90332-1. PMID7748561.
Kikutani H, Kumanogoh A (2003). "Semaphorins in interactions between T cells and antigen-presenting cells". Nat. Rev. Immunol. 3 (2): 159–67. doi:10.1038/nri1003. PMID12563299.
Kumanogoh A, Kikutani H (2004). "Immune semaphorins: a new area of semaphorin research". J. Cell Sci. 116 (Pt 17): 3463–70. doi:10.1242/jcs.00674. PMID12893810.
Elhabazi A, Marie-Cardine A, Chabbert-de Ponnat I, Bensussan A, Boumsell L (2004). "Structure and function of the immune semaphorin CD100/SEMA4D". Crit. Rev. Immunol. 23 (1–2): 65–81. doi:10.1615/CritRevImmunol.v23.i12.40. PMID12906260.
Kumanogoh A, Marukawa S, Suzuki K, Takegahara N, Watanabe C, Ch'ng E, Ishida I, Fujimura H, Sakoda S, Yoshida K, Kikutani H (2002). "Class IV semaphorin Sema4A enhances T-cell activation and interacts with Tim-2". Nature. 419 (6907): 629–33. doi:10.1038/nature01037. PMID12374982.
