SEC23B

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	Wikidata
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Protein transport protein Sec23B is a protein that in humans is encoded by the SEC23B gene.^[1]^[2]^[3]

The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The function of this gene product has been implicated in cargo selection and concentration.

Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.^[3] Mutations in SEC23B cause an autosomal recessive disorder called congenital dyserythropoietic anemia type II (CDAII).

References

↑ Paccaud JP, Reith W, Carpentier JL, Ravazzola M, Amherdt M, Schekman R, Orci L (Mar 1997). "Cloning and functional characterization of mammalian homologues of the COPII component Sec23". Mol Biol Cell. 7 (10): 1535–46. doi:10.1091/mbc.7.10.1535. PMC 276004. PMID 8898360.
↑ Tang BL, Kausalya J, Low DY, Lock ML, Hong W (Jun 1999). "A family of mammalian proteins homologous to yeast Sec24p". Biochem Biophys Res Commun. 258 (3): 679–84. doi:10.1006/bbrc.1999.0574. PMID 10329445.
↑ ^3.0 ^3.1 "Entrez Gene: SEC23B Sec23 homolog B (S. cerevisiae)".

Pagano A, Letourneur F, Garcia-Estefania D, et al. (1999). "Sec24 proteins and sorting at the endoplasmic reticulum". J. Biol. Chem. 274 (12): 7833–40. doi:10.1074/jbc.274.12.7833. PMID 10075675.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674.

This article on a gene on human chromosome 20 is a stub. You can help Wikipedia by expanding it.

[pmid8898360-1] Paccaud JP, Reith W, Carpentier JL, Ravazzola M, Amherdt M, Schekman R, Orci L (Mar 1997). "Cloning and functional characterization of mammalian homologues of the COPII component Sec23". Mol Biol Cell. 7 (10): 1535–46. doi:10.1091/mbc.7.10.1535. PMC 276004. PMID 8898360.

[pmid10329445-2] Tang BL, Kausalya J, Low DY, Lock ML, Hong W (Jun 1999). "A family of mammalian proteins homologous to yeast Sec24p". Biochem Biophys Res Commun. 258 (3): 679–84. doi:10.1006/bbrc.1999.0574. PMID 10329445.

[entrez-3] 3.0 ^3.1 "Entrez Gene: SEC23B Sec23 homolog B (S. cerevisiae)".

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SEC23B

References

Further reading

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