S100A13

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

S100 calcium-binding protein A13 (S100A13) is a protein that in humans is encoded by the S100A13 gene.

Function

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is widely expressed in various types of tissues with a high expression level in thyroid gland. In smooth muscle cells, this protein co-expresses with other family members in the nucleus and in stress fibers, suggesting diverse functions in signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.

Interactions

S100A13 has been shown to interact with SYT1 and FGF1.

Pathology

Up-regulation of S100A13 was detected in cystic papillary thyroid carcinoma and association of S100A13 expression and chemotherapy resistance was shown in proteomics study of melanoma.

Further reading

• Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O (Sep 1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID 7566098.
• Schäfer BW, Wicki R, Engelkamp D, Mattei MG, Heizmann CW (Feb 1995). "Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family". Genomics. 25 (3): 638–43. doi:10.1016/0888-7543(95)80005-7. PMID 7759097.
• Wicki R, Schäfer BW, Erne P, Heizmann CW (Oct 1996). "Characterization of the human and mouse cDNAs coding for S100A13, a new member of the S100 protein family". Biochemical and Biophysical Research Communications. 227 (2): 594–9. doi:10.1006/bbrc.1996.1551. PMID 8878558.
• Mouta Carreira C, LaVallee TM, Tarantini F, Jackson A, Lathrop JT, Hampton B, Burgess WH, Maciag T (Aug 1998). "S100A13 is involved in the regulation of fibroblast growth factor-1 and p40 synaptotagmin-1 release in vitro". The Journal of Biological Chemistry. 273 (35): 22224–31. doi:10.1074/jbc.273.35.22224. PMID 9712836.
• Ridinger K, Schäfer BW, Durussel I, Cox JA, Heizmann CW (Mar 2000). "S100A13. Biochemical characterization and subcellular localization in different cell lines". The Journal of Biological Chemistry. 275 (12): 8686–94. doi:10.1074/jbc.275.12.8686. PMID 10722710.
• Landriscina M, Bagalá C, Mandinova A, Soldi R, Micucci I, Bellum S, Prudovsky I, Maciag T (Jul 2001). "Copper induces the assembly of a multiprotein aggregate implicated in the release of fibroblast growth factor 1 in response to stress". The Journal of Biological Chemistry. 276 (27): 25549–57. doi:10.1074/jbc.M102925200. PMID 11432880.
• Hsieh HL, Schäfer BW, Cox JA, Heizmann CW (Aug 2002). "S100A13 and S100A6 exhibit distinct translocation pathways in endothelial cells". Journal of Cell Science. 115 (Pt 15): 3149–58. PMID 12118070.
• Prudovsky I, Bagala C, Tarantini F, Mandinova A, Soldi R, Bellum S, Maciag T (Jul 2002). "The intracellular translocation of the components of the fibroblast growth factor 1 release complex precedes their assembly prior to export". The Journal of Cell Biology. 158 (2): 201–8. doi:10.1083/jcb.200203084. PMC 2173119. PMID 12135982.
• Chan WY, Xia CL, Dong DC, Heizmann CW, Yew DT (Apr 2003). "Differential expression of S100 proteins in the developing human hippocampus and temporal cortex". Microscopy Research and Technique. 60 (6): 600–13. doi:10.1002/jemt.10302. PMID 12645008.
• Mandinova A, Soldi R, Graziani I, Bagala C, Bellum S, Landriscina M, Tarantini F, Prudovsky I, Maciag T (Jul 2003). "S100A13 mediates the copper-dependent stress-induced release of IL-1alpha from both human U937 and murine NIH 3T3 cells". Journal of Cell Science. 116 (Pt 13): 2687–96. doi:10.1242/jcs.00471. PMID 12746488.
• Hsieh HL, Schäfer BW, Weigle B, Heizmann CW (Apr 2004). "S100 protein translocation in response to extracellular S100 is mediated by receptor for advanced glycation endproducts in human endothelial cells". Biochemical and Biophysical Research Communications. 316 (3): 949–59. doi:10.1016/j.bbrc.2004.02.135. PMID 15033494.
• Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (Jan 2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
• Hayrabedyan S, Kyurkchiev S, Kehayov I (Mar 2005). "Endoglin (cd105) and S100A13 as markers of active angiogenesis in endometriosis". Reproductive Biology. 5 (1): 51–67. PMID 15821778.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS (Dec 2005). "Transcriptome analysis of human gastric cancer". Mammalian Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674.