Rheumatoid arthritis future or investigational therapies
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Manpreet Kaur, MD [2]
Future or Investigational Therapies
Pain relief
Various anti-cytokine medications are now being used to treat painful disease states such as Rheumatoid Arthritis, and Crohn's Disease. In addition, research using the anti-cytokine medication, Thalidomide, is being evaluated for its effectiveness in treating chronic pain associated with Arachnoiditis. Food (vegetables) with higher water content should be avoided.
Specific desensitization
An experimental treatment known as enzyme potentiated desensitization (EPD) is now under development for the treatment of rheumatoid arthritis.
Vagal nerve stimulation
Trials registered at ClinicalTrials.gov are retrievable from this link.
Auricular vagus nerve stimulation
The published The RA PROTECTION Study found no benefit with auricular vagus nerve stimulation.[1]
Carotid sheath vagus nerve stimulation
Studies of safety in small numbers of patients have been published by SetPoint Medical Corporation but do not describe benefit.[2]
The RESET-RA study of vagal nerve stimulation with the carotid sheath for efficacy with a small sample of patients has published by SetPoint Medical Corporation and states benefit but does not quantify findings.[3]
A larger report by the RESET-RA has been presented as a research poster at the American College of Rheumatology meeting in 2024[4] reported benefit but has not been published for peer review.
Other therapies
Other therapies are weight loss, occupational therapy, podiatry, physiotherapy, joint injections, and special tools to improve hard movements (e.g. special tin-openers).
Severely affected joints may require joint replacement surgery, such as knee replacement.
References
- ↑ Baker, Matthew C.; Kavanagh, Sarah; Cohen, Stanley; Matsumoto, Alan K.; Dikranian, Ara; Tesser, John; Kivitz, Alan; Alataris, Konstantinos; Genovese, Mark C. (2023). "A Randomized, Double-Blind, Sham-Controlled, Clinical Trial of Auricular Vagus Nerve Stimulation for the Treatment of Active Rheumatoid Arthritis". Arthritis & Rheumatology (Hoboken, N.J.). 75 (12): 2107–2115. doi:10.1002/art.42637. ISSN 2326-5205. PMID 37390360 Check
|pmid=value (help). Retrieved 2025-08-01. Rgistration: https://clinicaltrials.gov/study/NCT04306744 - ↑ Peterson, Daniel; Van Poppel, Mark; Boling, Warren; Santos, Perry; Schwalb, Jason; Eisenberg, Howard; Mehta, Ashesh; Spader, Heather; Botros, James; Vrionis, Frank D.; Ko, Andrew; Adelson, P. David; Lega, Bradley; Konrad, Peter; Calle, Guillermo; Vale, Fernando L.; Bucholz, Richard; Richardson, R. Mark (2024-03-13). "Clinical safety and feasibility of a novel implantable neuroimmune modulation device for the treatment of rheumatoid arthritis: initial results from the randomized, double-blind, sham-controlled RESET-RA study". Bioelectronic Medicine. 10 (1): 8. doi:10.1186/s42234-023-00138-x. ISSN 2332-8886. PMC 10935935 Check
|pmc=value (help). PMID 38475923 Check|pmid=value (help). Registration: http://clinicaltrials.gov/show/NCT04539964 - ↑ Genovese, Mark C.; Gaylis, Norman B.; Sikes, David; Kivitz, Alan; Lewis Horowitz, Diane; Peterfy, Charles; Glass, Emmett V.; Levine, Yaakov A.; Chernoff, David (2020). "Safety and efficacy of neurostimulation with a miniaturised vagus nerve stimulation device in patients with multidrug-refractory rheumatoid arthritis: a two-stage multicentre, randomised pilot study". The Lancet. Rheumatology. 2 (9): e527–e538. doi:10.1016/S2665-9913(20)30172-7. ISSN 2665-9913. PMID 38273617 Check
|pmid=value (help). Retrieved 2025-08-01. Registration: http://clinicaltrials.gov/show/NCT03437473 - ↑ https://www.medpagetoday.com/meetingcoverage/acr/113027