Rhabdomyolysis natural history, complications and prognosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Natural History, Complications and Prognosis

• Acute renal failure/Uremia: Estimated (1/3). Etiology multifactorial. Not only from pigmenturia. Has been seen with CKs as low as <20,000.
• Metabolic:

  • Hyperphosphatemia
  • Hyperkalemia: Can be to life threatening levels
  • Hypocalcemia: Thought to be caused by chelation of calcium phosphate into muscle. Eventually resolves and may overshoot.
  • Hyperuricemia

• Compartment syndromes: Compressive ischemia from swelling