Retinitis imaging findings
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Ilan Dock, B.S.
Overview
The optical coherence tomography (OCT) and the fundus autofluorescence (FAF) techniques are most often used when diagnosing a genetic variation of retinitis. OCT may be used to acquire in situ retinal imaging for diagnosis of ocular diseases. FAF imaging is a non-invasive technique, dependent on the presence of lipofuscin pigments (lipofuscin is a by-product of lysosomes during the normal process of photoreceptor degradation.)[1]
Imaging Findings
Retinitis pigmentosa
Optical Coherence Tomography
- An imaging technique used to acquire in situ retinal imaging for diagnosis of ocular diseases.
- Recent developments have revealed a highly reflective line, identified as the photoreceptor inner and outer segment (IS/OS); crucial for the diagnosis of retinitis pigmentosa.
- The line is an indicator of a normal alignment of the outer segment's membranous discs in the photoreceptor.
- The OCT should therefore display a continuous IS/OS line. This line serves as an indicator of good vision, as well as recovery from an invasive, intraocular surgery.[1]
Fundus Autofluorescence
- Noninvasive method of diagnosing retinal disease.
- FAF imaging is dependent on the presence of lipofuscin pigments (lipofuscin is a by-product of lysosomes during the normal process of photoreceptor degradation.)
- Identification of normal levels of lipofuscin indicates normal function of photoreceptor cells.
- Correct functioning of this cycle is dependent on normal function of retinal pigment epithelium and therefore may be used as a diagnostic tool for retinitis pigmentosa.
- More than half of patients suffering from retinitis pigmentosa will display a high density of FAF in the form of a parafoveal ring.[1]
References
- ↑ 1.0 1.1 1.2 Diagnostic imaging in patients with retinitis pigmentosa. Mitamura Y, Mitamura-aizawa S, Nagasawa T, Katome T, Eguchi H, Naito T. Diagnostic imaging in patients with retinitis pigmentosa. J Med Invest. 2012;59(1-2):1-11. http://www.ncbi.nlm.nih.gov/pubmed/22449988. Accessed April 19, 2016.