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Resolvins are compounds that are made by the human body from the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). They are produced by the COX-2 pathway especially in the presence of aspirin. Experimental evidence indicates that resolvins reduce cellular inflammation by inhibiting the production and transportation of inflammatory cells and chemicals to the sites of inflammation. They are released and used immunologically by the kidneys as a tool against acute renal failure, when it occurs. [1]

The EPA-derived resolvins are nonclassic eicosanoids.

External links

  1. Serhan CN, Hong S, Gronert K; et al. (2002). "Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals". J. Exp. Med. 196 (8): 1025–37. PMID 12391014. Retrieved 2007-11-02.

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