Primary mediastinal large B-cell lymphoma physical examination

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Badria Munir M.B.B.S.[2]

Overview

Patients with primary mediastinal large B-cell lymphoma usually appear normal. Physical examination of patients with primary mediastinal large B-cell lymphoma is usually remarkable for painless swellings, particularly [[swollen face]. Other physical findings include fever, lymphadenopaty.

Physical Examination

Physical examination of patients with primary mediastinal large B-cell lymphoma is usually normal.

Appearance of the Patient

• Patients with primary mediastinal large B-cell lymphoma usually appear normal.

Vitals

• Fever is often present

Skin

• Rash

HEENT

• Cervical lymphadenopathy
• Facial edema

Thorax

• Thoracic masses suggestive of central lymphadenopathy
• Localized anterosuperior mediastinal mass

Abdomen

• Abdominal masses suggestive of central lymphadenopathy

Extremities

• Peripheral lymphadenopathy

Laboratory Findings

Laboratory tests for primary mediastinal large B-cell lymphoma include:

• Complete blood count (CBC)
• Blood chemistry studies
• Liver function tests
• Serum LDH levels
• Beta 2 microglobulin levels
• Cytogenetic analysis
• Flow cytometry
• Immunohistochemistry
• Immunophenotyping
  • Positive: CD19, CD79a, CD20, CD30, and CD22