Polycystic kidney disease laboratory findings
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: M. Khurram Afzal, MD [2], Serge Korjian,Yazan Daaboul
Overview
Common laboratory findings in polycystic kidney disease are urinary abnormalities including reduction in concentration capacity, hypocitraturia, hematuria, and proteinuria. Hyperuricemia is also a common finding and is a risk factor for disease progression and ESRD.
Laboratory Findings
Laboratory findings in polycystic kidney disease are usually confined to urinary abnormalities, which include:[1]
- Reduction in maximal urine concentration after water deprivation and ADH administration (usually first manifestation of disease)
- Hypocitraturia in 65% on patients
- Hyperuricemia in 20% of patients
- Hyperoxaluria in 20% of patients
- Low urine pH
- Hematuria (microscopic or macroscopic)
- Proteinuria usually less than 1 g/day
References
- ↑ Fick GM, Gabow PA (1994). "Natural history of autosomal dominant polycystic kidney disease". Annu Rev Med. 45: 23–9. doi:10.1146/annurev.med.45.1.23. PMID 8198379.