Piperaquine

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Piperaquine
	File:Piperaquine.png
Identifiers
	IUPAC name 7-chloro-4-[4-[3-[4-(7-chloroquinolin-4-yl)piperazin-1-yl]propyl];
CAS Number	4085-31-8 ;
PubChem CID	122262;
UNII	A0HV2Q956Y;
ChEMBL	ChEMBL303933 ;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C29H32Cl2N6
Molar mass	535.51
3D model (JSmol)	Interactive image;
	SMILES C1CN(CCN1CCCN2CCN(CC2)C3=C4C=CC(=CC4=NC=C3)Cl)C5=C6C=CC(=CC6=NC=C5)Cl;
(what is this?) (verify)

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Piperaquine is an antimalarial drug, a bisquinoline first synthesised in the 1960s, and used extensively in China and Indochina as prophylaxis and treatment during the next 20 years. Usage declined in the 1980s as piperaquine-resistant strains of P. falciparum arose and artemisinin-based antimalarials became available. However, Chinese scientists have been studying whether piperaquine can still be used therapeutically in combination with artemisinin.^[1]

Piperaquine is characterized by slow absorption and a long biological half-life,^[2] making it a good partner drug with artemisinin derivatives which are fast acting but have a short biological half-life.^[3]

The fixed-dose combination dihydroartemisinin-piperaquine (Eurartesim) was submitted for approval to the European Medicines Agency in 2009.^[4]

References

↑ Davis TM, Hung TY, Sim IK, Karunajeewa HA, Ilett KF (2005). "Piperaquine: a resurgent antimalarial drug". Drugs. 65 (1): 75–87. PMID 15610051.
↑ D'alessandro U. (2009). "Progress in the development of piperaquine combinations for the treatment of malaria". Curr Opin Infect Dis. 22 (6): 588–92. PMID 19773652.
↑ http://apps.who.int/prequal/info_applicants/Guidelines/Nonclinical_Overview_Artemisinin-Derivatives.pdf"
↑ Medicines for Malaria. "Registration". Retrieved 2010-06-20.

Template:Antiinfective-drug-stub

[1] Davis TM, Hung TY, Sim IK, Karunajeewa HA, Ilett KF (2005). "Piperaquine: a resurgent antimalarial drug". Drugs. 65 (1): 75–87. PMID 15610051.

[2] D'alessandro U. (2009). "Progress in the development of piperaquine combinations for the treatment of malaria". Curr Opin Infect Dis. 22 (6): 588–92. PMID 19773652.

[3] ttp://apps.who.int/prequal/info_applicants/Guidelines/Nonclinical_Overview_Artemisinin-Derivatives.pdf"

[4] Medicines for Malaria. "Registration". Retrieved 2010-06-20.

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Identifiers
File:Piperaquine.png
IUPAC name 7-chloro-4-[4-[3-[4-(7-chloroquinolin-4-yl)piperazin-1-yl]propyl]
CAS Number	4085-31-8^Y
PubChem CID	122262
UNII	A0HV2Q956Y
ChEMBL	ChEMBL303933^N
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C₂₉H₃₂Cl₂N₆
Molar mass	535.51
3D model (JSmol)	Interactive image
SMILES C1CN(CCN1CCCN2CCN(CC2)C3=C4C=CC(=CC4=NC=C3)Cl)C5=C6C=CC(=CC6=NC=C5)Cl
^NY (what is this?) (verify)

Piperaquine

Overview

References

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