Phosphate-transporting ATPase

In enzymology, a phosphate-transporting ATPase (EC 3.6.3.27) is an enzyme that catalyzes the chemical reaction

ATP + H₂O + phosphateout <math>\rightleftharpoons</math> ADP + phosphate + phosphatein

The 3 substrates of this enzyme are ATP, H₂O, and phosphate, whereas its two products are ADP and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides to catalyse transmembrane movement of substances. The systematic name of this enzyme class is ATP phosphohydrolase (phosphate-importing). This enzyme is also called ABC phosphate transporter. This enzyme participates in abc transporters - general.

References

• Webb DC, Rosenberg H, Cox GB (1992). "Mutational analysis of the Escherichia coli phosphate-specific transport system, a member of the traffic ATPase (or ABC) family of membrane transporters. A role for proline residues in transmembrane helices". J. Biol. Chem. 267: 24661&ndash, 8. PMID 1447208.CS1 maint: Multiple names: authors list (link)
• Kuan G, Dassa E, Saurin W, Hofnung M, Saier MH Jr (1995). "Phylogenetic analyses of the ATP-binding constituents of bacterial extracytoplasmic receptor-dependent ABC-type nutrient uptake permeases". Res. Microbiol. 146: 271&ndash, 8. PMID 7569321.CS1 maint: Multiple names: authors list (link)
• R, Content J (1996). "Identification of a second Mycobacterium tuberculosis gene cluster encoding proteins of an ABC phosphate transporter". FEBS. Lett. 394: 206&ndash, 12. PMID 8843165.
• Saier MH Jr (1998). "Molecular phylogeny as a basis for the classification of transport proteins from bacteria, archaea and eukarya". Adv. Microb. Physiol. 40: 81&ndash, 136. PMID 9889977.
• Griffiths JK and Sansom CE. "The Transporter Factsbook, Academic Press, San Diego, 1998".