PPP2R2B

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View/Edit Human

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform is an enzyme that in humans is encoded by the PPP2R2B gene.^[1]^[2]

The product of this gene belongs to the phosphatase 2regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B55 subfamily. Defects in the 5' UTR of this gene may cause a rare form of autosomal dominant spinocerebellar ataxia 12.^[3]

References

↑ Mayer RE, Hendrix P, Cron P, Matthies R, Stone SR, Goris J, Merlevede W, Hofsteenge J, Hemmings BA (May 1991). "Structure of the 55-kDa regulatory subunit of protein phosphatase 2A: evidence for a neuronal-specific isoform". Biochemistry. 30 (15): 3589–97. doi:10.1021/bi00229a001. PMID 1849734.
↑ Holmes SE, O'Hearn EE, McInnis MG, Gorelick-Feldman DA, Kleiderlein JJ, Callahan C, Kwak NG, Ingersoll-Ashworth RG, Sherr M, Sumner AJ, Sharp AH, Ananth U, Seltzer WK, Boss MA, Vieria-Saecker AM, Epplen JT, Riess O, Ross CA, Margolis RL (Dec 1999). "Expansion of a novel CAG trinucleotide repeat in the 5' region of PPP2R2B is associated with SCA12". Nat Genet. 23 (4): 391–2. doi:10.1038/70493. PMID 10581021.
↑ "Entrez Gene: PPP2R2B protein phosphatase 2 (formerly 2A), regulatory subunit B, beta isoform".

Millward TA, Zolnierowicz S, Hemmings BA (1999). "Regulation of protein kinase cascades by protein phosphatase 2A". Trends Biochem. Sci. 24 (5): 186–91. doi:10.1016/S0968-0004(99)01375-4. PMID 10322434.
Andersen JL, Planelles V (2005). "The role of Vpr in HIV-1 pathogenesis". Curr. HIV Res. 3 (1): 43–51. doi:10.2174/1570162052772988. PMID 15638722.
Le Rouzic E, Benichou S (2006). "The Vpr protein from HIV-1: distinct roles along the viral life cycle". Retrovirology. 2: 11. doi:10.1186/1742-4690-2-11. PMC 554975. PMID 15725353.
Zhao RY, Elder RT (2005). "Viral infections and cell cycle G2/M regulation". Cell Res. 15 (3): 143–9. doi:10.1038/sj.cr.7290279. PMID 15780175.
Zhao RY, Bukrinsky M, Elder RT (2005). "HIV-1 viral protein R (Vpr) & host cellular responses". Indian J. Med. Res. 121 (4): 270–86. PMID 15817944.
Schalling M, Hudson TJ, Buetow KH, Housman DE (1993). "Direct detection of novel expanded trinucleotide repeats in the human genome". Nat. Genet. 4 (2): 135–9. doi:10.1038/ng0693-135. PMID 8348150.
Tung HY, De Rocquigny H, Zhao LJ, et al. (1997). "Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr". FEBS Lett. 401 (2–3): 197–201. doi:10.1016/S0014-5793(96)01470-6. PMID 9013886.
Ruediger R, Brewis N, Ohst K, Walter G (1998). "Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production". Virology. 238 (2): 432–43. doi:10.1006/viro.1997.8873. PMID 9400615.
Strack S, Zaucha JA, Ebner FF, et al. (1998). "Brain protein phosphatase 2A: developmental regulation and distinct cellular and subcellular localization by B subunits". J. Comp. Neurol. 392 (4): 515–27. doi:10.1002/(SICI)1096-9861(19980323)392:4<515::AID-CNE8>3.0.CO;2-3. PMID 9514514.
Fujigasaki H, Verma IC, Camuzat A, et al. (2001). "SCA12 is a rare locus for autosomal dominant cerebellar ataxia: a study of an Indian family". Ann. Neurol. 49 (1): 117–21. doi:10.1002/1531-8249(200101)49:1<117::AID-ANA19>3.0.CO;2-G. PMID 11198281.
Elder RT, Yu M, Chen M, et al. (2001). "HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25". Virology. 287 (2): 359–70. doi:10.1006/viro.2001.1007. PMID 11531413.
Guo CY, Brautigan DL, Larner JM (2002). "ATM-dependent dissociation of B55 regulatory subunit from nuclear PP2A in response to ionizing radiation". J. Biol. Chem. 277 (7): 4839–44. doi:10.1074/jbc.M110092200. PMID 11723136.
Bennin DA, Don AS, Brake T, et al. (2002). "Cyclin G2 associates with protein phosphatase 2A catalytic and regulatory B' subunits in active complexes and induces nuclear aberrations and a G1/S phase cell cycle arrest". J. Biol. Chem. 277 (30): 27449–67. doi:10.1074/jbc.M111693200. PMID 11956189.
Okamoto K, Li H, Jensen MR, et al. (2002). "Cyclin G recruits PP2A to dephosphorylate Mdm2". Mol. Cell. 9 (4): 761–71. doi:10.1016/S1097-2765(02)00504-X. PMID 11983168.
Marmorstein LY, McLaughlin PJ, Stanton JB, et al. (2002). "Bestrophin interacts physically and functionally with protein phosphatase 2A". J. Biol. Chem. 277 (34): 30591–7. doi:10.1074/jbc.M204269200. PMID 12058047.
Hrimech M, Yao XJ, Branton PE, Cohen EA (2002). "Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A". EMBO J. 21 (14): 3918. doi:10.1093/emboj/cdf420. PMC 126131. PMID 12110603.

External links

GeneReviews/NCBI/NIH/UW entry on Spinocerebellar Ataxia Type 12

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by expanding it.

[pmid1849734-1] Mayer RE, Hendrix P, Cron P, Matthies R, Stone SR, Goris J, Merlevede W, Hofsteenge J, Hemmings BA (May 1991). "Structure of the 55-kDa regulatory subunit of protein phosphatase 2A: evidence for a neuronal-specific isoform". Biochemistry. 30 (15): 3589–97. doi:10.1021/bi00229a001. PMID 1849734.

[pmid10581021-2] Holmes SE, O'Hearn EE, McInnis MG, Gorelick-Feldman DA, Kleiderlein JJ, Callahan C, Kwak NG, Ingersoll-Ashworth RG, Sherr M, Sumner AJ, Sharp AH, Ananth U, Seltzer WK, Boss MA, Vieria-Saecker AM, Epplen JT, Riess O, Ross CA, Margolis RL (Dec 1999). "Expansion of a novel CAG trinucleotide repeat in the 5' region of PPP2R2B is associated with SCA12". Nat Genet. 23 (4): 391–2. doi:10.1038/70493. PMID 10581021.

[entrez-3] "Entrez Gene: PPP2R2B protein phosphatase 2 (formerly 2A), regulatory subunit B, beta isoform".

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[2]

[3]

PPP2R2B

References

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