PACRG

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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View/Edit Human

Parkin coregulated gene protein is a protein that in humans is encoded by the PACRG gene.[1][2]

This gene encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene.[2]

References

  1. West AB, Lockhart PJ, O'Farell C, Farrer MJ (Jan 2003). "Identification of a novel gene linked to parkin via a bi-directional promoter". J Mol Biol. 326 (1): 11–9. doi:10.1016/S0022-2836(02)01376-1. PMID 12547187.
  2. 2.0 2.1 "Entrez Gene: PACRG PARK2 co-regulated".

Further reading