Neonatal alloimmune thrombocytopenia causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Causes

About 80% of cases of NAIT are caused by antibodies against platelet antigen HP-1a, 15% by anti-HP-5a, and 5% by other antibodies. Unlike the hemolytic disease, NAIT occurs during the first pregnancy in to 50% of cases, and the affected fetuses may develop severe thrombocytopenia (<50,000 /μL) very early during pregnancy. Usually, the thrombocytopenia increases as gestation progresses.