Nalfurafine

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Nalfurafine
Clinical data
Synonyms	TRK-820
AHFS/Drugs.com	International Drug Names
Routes of; administration	intravenous
ATC code	V03AX02 (WHO) ;
Identifiers
	IUPAC name (2E)-N-[(5α,6β)-17-(cyclopropylmethyl)- 3,14-dihydroxy- 4,5-epoxymorphinan- 6-yl]- 3-(3-furyl)- N-methylacrylamide;
CAS Number	152658-17-8 ;
PubChem CID	6445230;
IUPHAR/BPS	1651;
ChemSpider	4949003 ;
UNII	XC41AVD567;
ChEMBL	ChEMBL267495 ;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C28H32N2O5
Molar mass	476.564 g/mol
3D model (JSmol)	Interactive image;
	SMILES CN([C@@H]1CC[C@]2([C@H]3CC4=C5[C@]2([C@H]1OC5=C(C=C4)O)CCN3CC6CC6)O)C(=O)/C=C/C7=COC=C7;
	InChI InChI=1S/C28H32N2O5/c1-29(23(32)7-4-18-9-13-34-16-18)20-8-10-28(33)22-14-19-5-6-21(31)25-24(19)27(28,26(20)35-25)11-12-30(22)15-17-2-3-17/h4-7,9,13,16-17,20,22,26,31,33H,2-3,8,10-12,14-15H2,1H3/b7-4+/t20-,22-,26+,27+,28-/m1/s1 ; Key:XGZZHZMWIXFATA-UEZBDDGYSA-N ;
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Nalfurafine (INN and USAN;^[1] also known as AC-820, TRK-820; trade name Remitch) is a κ-opioid receptor agonist marketed as a treatment for uremic pruritus in people undergoing hemodialysis.^[2]

As of January 2010^[update], it is also being investigated for the treatment of pruritus in patients with chronic liver disease.^[3]

References

↑ Statement on a Nonproprietary Name adopted by the USAN Council
↑ "AC-820". Acologix. 2009.
↑ Clinical trial number NCT00638495 for "Phase II Study of TRK-820 Soft Capsules — Intractable Pruritus in Patients With Chronic Liver Disease" at ClinicalTrials.gov

[1] Statement on a Nonproprietary Name adopted by the USAN Council

[2] "AC-820". Acologix. 2009.

[3] Clinical trial number NCT00638495 for "Phase II Study of TRK-820 Soft Capsules — Intractable Pruritus in Patients With Chronic Liver Disease" at ClinicalTrials.gov

[1]

[2]

[3]

Nalfurafine

Overview

References

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