NRD1

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

Nardilysin is a protein that in humans is encoded by the NRD1 gene.

Interactions

NRD1 has been shown to interact with Heparin-binding EGF-like growth factor.

Further reading

• Seidah NG, Prat A (2003). "Precursor convertases in the secretory pathway, cytosol and extracellular milieu". Essays Biochem. 38: 79–94. PMID 12463163.
• Hospital V, Prat A (2005). "Nardilysin, a basic residues specific metallopeptidase that mediates cell migration and proliferation". Protein Pept. Lett. 11 (5): 501–8. doi:10.2174/0929866043406508. PMID 15544571.
• Winter AG, Pierotti AR (2001). "Gene expression of the dibasic-pair cleaving enzyme NRD convertase (N-arginine dibasic convertase) is differentially regulated in the GH3 pituitary and Mat-Lu prostate cell lines". Biochem. J. 351 (3): 755–64. doi:10.1042/0264-6021:3510755. PMC 1221416. PMID 11042131.
• Nishi E, Prat A, Hospital V, et al. (2001). "N-arginine dibasic convertase is a specific receptor for heparin-binding EGF-like growth factor that mediates cell migration". EMBO J. 20 (13): 3342–50. doi:10.1093/emboj/20.13.3342. PMC 125525. PMID 11432822.
• Ma Z, Csuhai E, Chow KM, Hersh LB (2001). "Expression of the acidic stretch of nardilysin as a functional binding domain". Biochemistry. 40 (31): 9447–52. doi:10.1021/bi010538x. PMID 11478915.
• Hospital V, Nishi E, Klagsbrun M, et al. (2003). "The metalloendopeptidase nardilysin (NRDc) is potently inhibited by heparin-binding epidermal growth factor-like growth factor (HB-EGF)". Biochem. J. 367 (Pt 1): 229–38. doi:10.1042/BJ20020822. PMC 1222870. PMID 12095415.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Chow KM, Oakley O, Goodman J, et al. (2003). "Nardilysin cleaves peptides at monobasic sites". Biochemistry. 42 (7): 2239–44. doi:10.1021/bi027178d. PMID 12590613.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
• Nishi E, Hiraoka Y, Yoshida K, et al. (2006). "Nardilysin enhances ectodomain shedding of heparin-binding epidermal growth factor-like growth factor through activation of tumor necrosis factor-alpha-converting enzyme". J. Biol. Chem. 281 (41): 31164–72. doi:10.1074/jbc.M601316200. PMID 16923819.
• Bernstein HG, Stricker R, Dobrowolny H, et al. (2007). "Histochemical evidence for wide expression of the metalloendopeptidase nardilysin in human brain neurons". Neuroscience. 146 (4): 1513–23. doi:10.1016/j.neuroscience.2007.02.057. PMID 17442499.