Mycobacterium abscessus diagnostic criteria
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Rim Halaby, M.D. [2]
Overview
When symptoms suggestive skin and soft tissues infection with mycobacterium abscessus (M. abscessus) are present, the definitive diagnosis requires the isolation of the organism from the infection site or, in severe cases, from a blood culture. The diagnosis of pulmonary M. abscessus infection requires the presence of clinical, radiological and microbiological diagnostic criteria.[1]
Diagnostic Criteria for Skin and Soft Tissues Infection
There is no formal diagnostic criteria for skin and soft tissues M. abscessus infection. Clinically, the disease is characterized by red/purple, warm, tender to the touch, swollen, and/or painful skin. To reach a definitive diagnosis, the organism has to be cultured from the infection site or, in severe cases, from a blood culture.
Diagnostic Criteria for Pulmonary Mycobacterium Abscessus
The diagnosis of pulmonary M. abscessus infection requires the presence of clinical and microbiological criteria.[1]
Clinical Diagnostic Criteria
- Pulmonary symptoms, OR
- Cavitation or nodular opacities on chest X-ray, OR
- Multifocal bronchiectasis with multiple small nodules on high resolution CT scan (HRCT scan)
AND
- Other diagnoses, such as tuberculosis, are ruled out[1]
Microbiological Diagnostic Criteria
- Positive culture from ≥2 different expectorated sputum samples
OR
- Positive culture from ≥1 bronchial wash or bronchial lavage
OR
- Histopathologic features of mycobacterial infection in transbronchial or lung biopsy AND positive culture for M. abscessus
OR
- Histopathologic features of mycobacterial infection in transbronchial or lung biopsy AND positive culture of ≥1 expectorated sputum or bronchial wash samples[1]
References
- ↑ 1.0 1.1 1.2 1.3 Griffith DE, Aksamit T, Brown-Elliott BA, Catanzaro A, Daley C, Gordin F; et al. (2007). "An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases". Am J Respir Crit Care Med. 175 (4): 367–416. doi:10.1164/rccm.200604-571ST. PMID 17277290.