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Macromerine is a psychedelic, hallucinogenic and entheogenic of the phenethylamine family. It can be synthesized or extracted from the Doñana (Coryphantha macromeris), C. macromeris v. runyonii, C. elephantidens, and other related members of the Cactaceae family. The plants may have been used by Tarahumara shamans for their entheogenic effects.


Macromerine is in a family of chemicals called the phenethylamines, and it is a close analogue of mescaline. The full chemical name of macromerine is 1-(3,4-dimethoxyphenyl)-2-(dimethylamino)ethanol.


Macromerine is said to have "1/5th" the potency of mescaline, so a dosage could be 1250-2500 mg based on the dosage of mescaline sulfate.


Little is known about the psychedelic effects of macromerine. K. Trout states that a bioassay of macromerine-containing cactus, Doñana, "had been very mild and very strange, with many waves of intense nausea and extremely persistent after effects, such as distorted vision and a very weird feeling of unreality lasting for weeks after its use."

However, considering Doñana is usually no more than 0.1 percent macromerine, several pounds of the dried cactus would be required to consume a psychedelic dosage of macromerine. What is more likely is that the combination of all alkaloids present in the cactus produce the effects of Doñana.


Macromerine is not illegal in any known part of the world, but possession and sales of macromerine could be prosecuted under the Federal Analog Act in the USA because of its structural similarities to mescaline.

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