MYOC

Myocilin, trabecular meshwork inducible glucocorticoid response
Identifiers
Symbols	MYOC ; GLC1A; GPOA; JOAG; JOAG1; TIGR; myocilin
External IDs	Template:OMIM5 Template:MGI HomoloGene: 220
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE MYOC 210155 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

WikiDoc Resources for MYOC
Articles
Most recent articles on MYOC Most cited articles on MYOC Review articles on MYOC Articles on MYOC in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on MYOC Images of MYOC Photos of MYOC Podcasts & MP3s on MYOC Videos on MYOC
Evidence Based Medicine
Cochrane Collaboration on MYOC Bandolier on MYOC TRIP on MYOC
Clinical Trials
Ongoing Trials on MYOC at Clinical Trials.gov Trial results on MYOC Clinical Trials on MYOC at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on MYOC NICE Guidance on MYOC NHS PRODIGY Guidance FDA on MYOC CDC on MYOC
Books
Books on MYOC
News
MYOC in the news Be alerted to news on MYOC News trends on MYOC
Commentary
Blogs on MYOC
Definitions
Definitions of MYOC
Patient Resources / Community
Patient resources on MYOC Discussion groups on MYOC Patient Handouts on MYOC Directions to Hospitals Treating MYOC Risk calculators and risk factors for MYOC
Healthcare Provider Resources
Symptoms of MYOC Causes & Risk Factors for MYOC Diagnostic studies for MYOC Treatment of MYOC
Continuing Medical Education (CME)
CME Programs on MYOC
International
MYOC en Espanol MYOC en Francais
Business
MYOC in the Marketplace Patents on MYOC
Experimental / Informatics
List of terms related to MYOC

Myocilin, trabecular meshwork inducible glucocorticoid response, also known as MYOC, is a human gene.

MYOC encodes the protein myocilin, which is believed to have a role in cytoskeletal function. MYOC is expressed in many occular tissues, including the trabecular meshwork, and was revealed to be the trabecular meshwork glucocorticoid-inducible response protein (TIGR). The trabecular meshwork is a specialized eye tissue essential in regulating intraocular pressure, and mutations in MYOC have been identified as the cause of hereditary juvenile-onset open-angle glaucoma.

Further reading

• Fingert JH, Stone EM, Sheffield VC, Alward WL (2003). "Myocilin glaucoma". Survey of ophthalmology. 47 (6): 547–61. PMID 12504739.CS1 maint: Multiple names: authors list (link)
• Polansky JR (2004). "Current perspectives on the TIGR/MYOC gene (Myocilin) and glaucoma". Ophthalmology clinics of North America. 16 (4): 515–27, v–vi. PMID 14740993.
• Coca-Prados M, Escribano J (2007). "New perspectives in aqueous humor secretion and in glaucoma: the ciliary body as a multifunctional neuroendocrine gland". Progress in retinal and eye research. 26 (3): 239–62. doi:10.1016/j.preteyeres.2007.01.002. PMID 17321191.