M2 AML

M2 AML
ICD-O:	9874/3

WikiDoc Resources for M2 AML
Articles
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Evidence Based Medicine
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Clinical Trials
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Definitions
Definitions of M2 AML
Patient Resources / Community
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List of terms related to M2 AML

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

M2 is a subtype of AML (Acute Myeloid Leukemia).

Pathophysiology

This subtype is characterized by a translocation of a part of chromosome 8 to chromosome 21, written as t(8;21). On both sides of the chromosome, now containing pieces from two chromosomes, the DNA codes for different proteins. These two proteins are now being created as one single large protein, with a different effect in the body as the two proteins originally coded by the two different chromosomes. The two different proteins that are fused together are:

• RUNX1
• ETO

Related chapters

Main article: Acute myeloid leukemia

References

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