Liver transplantation historical perspective

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohammed Abdelwahed M.D[2]

Liver trasnsplantation Microchapters

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Overview

Historical Perspective

Indications

Pre-surgical management

Choice of donor

Epidemiology and Demographics

Techniques

Complications

Acute rejection

Immune therapy

Post-surgical infection

Prognosis

Overview

In 1952, Vittorio Staudacher was the first to perform a liver transplantation (LT) in a canine species. In 1968, Roy Calne and Roger Williams reported 5 cases of liver transplant, discussing the technical problems by details. In 1984, Bismuth reported the first left-lobe LT in a child. Now, there are hundreds of liver transplant centres in over 80 countries.

Liver transplantation historical perspective

  • In 1952, Vittorio Staudacher was the first to perform a liver transplantation (LT) in a canine species.[1]
  • Thomas Starzl published the first three attempts at human LT. In 1967 the procedure resulted in the first extended survival.[2]
  • In 1968, Roy Calne and Roger Williams reported 5 cases of liver transplant, discussing the technical problems by details.[3]
  • In the late 1970s, the introduction of cyclosporine as part of the immunosuppressive regimen in organ transplantation permitted prevention of rejection and severe opportunistic infections when compared to azathioprine.[4]
  • In 1984, Bismuth reported the first left-lobe LT in a child.
  • In 1988, Pichlmayr performed the first split-LT in Germany.
  • In 1985, Silvano Raia described the first attempt at a living donor graft in a child.[5]
  • Since the nineties, there are hundreds of liver transplant centres in over 80 countries.

References

  1. ↑ Busuttil RW, De Carlis LG, Mihaylov PV, Gridelli B, Fassati LR, Starzl TE (2012). "The first report of orthotopic liver transplantation in the Western world". Am J Transplant. 12 (6): 1385–7. doi:10.1111/j.1600-6143.2012.04026.x. PMID 22458426.
  2. ↑ STARZL TE, MARCHIORO TL, VONKAULLA KN, HERMANN G, BRITTAIN RS, WADDELL WR (1963). "HOMOTRANSPLANTATION OF THE LIVER IN HUMANS". Surg Gynecol Obstet. 117: 659–76. PMC 2634660. PMID 14100514.
  3. ↑ Zarrinpar A, Busuttil RW (2013). "Liver transplantation: past, present and future". Nat Rev Gastroenterol Hepatol. 10 (7): 434–40. doi:10.1038/nrgastro.2013.88. PMID 23752825.
  4. ↑ Calne RY, Rolles K, White DJ, Thiru S, Evans DB, McMaster P; et al. (1979). "Cyclosporin A initially as the only immunosuppressant in 34 recipients of cadaveric organs: 32 kidneys, 2 pancreases, and 2 livers". Lancet. 2 (8151): 1033–6. PMID 91781.
  5. ↑ Strong RW, Lynch SV, Ong TH, Matsunami H, Koido Y, Balderson GA (1990). "Successful liver transplantation from a living donor to her son". N Engl J Med. 322 (21): 1505–7. doi:10.1056/NEJM199005243222106. PMID 2336076.

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