Lidoflazine

Lidoflazine

Clinical data
ATC code	C08EX01 (WHO)
Identifiers
IUPAC name 2-[4-[4,4-bis(4-fluorophenyl)butyl]piperazin-1-yl]-N-(2,6-dimethylphenyl)acetamide
CAS Number	3416-26-0
PubChem CID	3926
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C30H35F2N3O
Molar mass	491.615

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Lidoflazine is a piperazine calcium channel blocker. It is a coronary vasodilator with some antiarrhythmic action. Lidoflazine was discovered at Janssen Pharmaceutica in 1964.

Physical properties

Solubility at room temperature

Extracted from

Solvent	0.01 N		0.1 N
		%	pH	%	pH
Hydrochloric Acid	0.4	3.0	0.7	1.9
Tartaric Acid	0.3	3.1	1.0	2.5
Citric Acid	0.3	3.1	0.5	2.5
Lactic Acid	0.2	3.4	0.7	2.9
Acetic Acid	0.1	3.5	0.4	3.8

References

• Schaper WK, Xhonneux R, Jageneau AH., Stimulation of the coronary collateral circulation by lidoflazine (R 7904), Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1965 Nov 4;252(1):1-8.
• Schaper WK, Xhoneux R, Jageneau AH, Janssen PA., The cardiovascular pharmacology of lidoflazine, a long-acting coronary vasodilator, J Pharmacol Exp Ther. 1966 May;152(2):265-74.