Lactic acidosis risk factors

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Saud Khan M.D.

Overview

Common risk factors in the development of lactic acidosis are:

  • Diabetics taking metformin and SGLT2 inhibitors, especially in conjunction with active COVID-19[1]
  • Underlying sepsis
  • Septic, cardiogenic or haemorrhagic shock


Risk factors

Lactic acidosis predisposing factors are reported to include:

  • Acute kidney injury
  • Previous history of lactic acidosis
  • Hypovolemia
  • Hemodynamic instability due to infection or other causes
  • Seizure
  • Concurrent liver disease
  • Alcohol abuse
  • Acute heart failure/Myocardial infarction
  • Shock due to any cause

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References

  1. Orioli L, Hermans MP, Thissen JP, Maiter D, Vandeleene B, Yombi JC (2020). "COVID-19 in diabetic patients: Related risks and specifics of management". Ann Endocrinol (Paris). 81 (2–3): 101–109. doi:10.1016/j.ando.2020.05.001. PMC 7217100 Check |pmc= value (help). PMID 32413342 Check |pmid= value (help).


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